Accès ouvert
2022
article
OpenAlex
Matthias L Herrmann, Cindy Boden, Christoph J. Maurer, Felix Kentischer et autres
Introduction: Postoperative delirium (POD) is a common and serious adverse event of surgery in older people. Because of its great impact on patients' safety and quality of life, identification of modifiable risk factors could be useful. Although preoperative medication intake is assumed …
de, us
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Accès ouvert
2022
article
OpenAlex
Luisa Herrmann, Vanessa Kasties, Cindy Boden, Meng Li et autres
OBJECTIVE: Stress-related symptoms are associated with significant health and economic burden. Several studies suggest Nx4 for the pharmacological management of the stress response and investigated the underlying neural processes. Here we hypothesized that Nx4 can directly affect the stress response in a …
de, nl, se
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Accès ouvert
2021
article
OpenAlex
Friederike Deeken, Alba Sánchez, Michael A. Rapp, Michael Dieter Denkinger et autres
Importance: Delirium significantly worsens elective surgery outcomes and costs. Delirium risk is highest in elderly populations, whose surgical health care resource consumption (50%) exceeds their demographic proportion (15% to 18%) in high-resource countries. Effective nonpharmacologic delirium prevention could safely improve care in …
de, ca
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2017
article
OpenAlex
Carola Rotermund, Gustavo Kellermann Reolon, Sarah Leixner, Cindy Boden et autres
α-Synuclein (αSYN) is the neuropathological hallmark protein of Parkinson's disease (PD) and related neurodegenerative disorders. Moreover, the gene encoding αSYN (SNCA) is a major genetic contributor to PD. Interestingly, independent genome-wide association studies also identified SNCA as the most important candidate gene …
de
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Accès ouvert
2013
article
OpenAlex
Mitchell Paul Levesque, Jana Krauß, Carla M. Koehler, Cindy Boden et autres
We have conducted a screen to identify developmentally regulated enhancers that drive tissue-specific Gal4 expression in zebrafish. We obtained 63 stable transgenic lines with expression patterns in embryonic or adult zebrafish. The use of a newly identified minimal promoter from the medaka …
ch, de, us
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Accès ouvert
2012
article
OpenAlex
Heinrich Schell, Cindy Boden, André Maia Chagas, Philipp J. Kahle
α-Synuclein (αSYN) is genetically and neuropathologically linked to a spectrum of neurodegenerative diseases including Parkinson's disease, dementia with Lewy bodies, and related disorders. Cognitive impairment is recapitulated in several αSYN transgenic mouse lines. However, the mechanisms of dysfunction in affected neurons are …
de
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Accès ouvert
2011
article
OpenAlex
Claus Rieker, Kumlesh Kumar Dev, Katja Lehnhoff, Samuel Barbieri et autres
α-Synuclein (αSN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (mαSN), which carries a threonine at position 53 like the A53T human mutant version that …
ch, ie, de
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2000
article
OpenAlex
WQ Sturner, MA Herrmann, Cindy Boden, TP Scarritt et autres
State Supreme Courts require a minimum threshold of reliability and acceptance in the scientific community for all medical and similar evidence to be admitted at trial. In Florida and some other states, the courts adhere to what is known as the Frye …
us, ca, jp
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Accès ouvert
1996
article
OpenAlex
Joep Perk, Lars Perk, Cindy Boden
Physical training in water might be included in a comprehensive pulmonary rehabilitation programme, but data on the feasibility and safety of this technique in chronic obstructive pulmonary disease (COPD) patients are lacking. We studied cardiorespiratory parameters of 20 stable COPD patients (10 …
se
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