Burton Kuan Hui Chia

Isoform-level discovery, quantification and fusion analysis from single-cell and spatial long-read RNA-seq data with Bambu-Clump

Andre Sim, Min Hao Ling, Ying Chen, Lu Han et autres

Abstract Single cell and spatial transcriptomics have dramatically changed how we can profile RNA from heterogenous biological samples. Combining single cell and spatial profiling with long read RNA-Seq promises to enable the discovery and quantification of individual RNA isoforms at the single-cell …

sg (code pays fourni par la source)

Integrative genomic analyses of European intrahepatic cholangiocarcinoma: Novel ROS1 fusion gene and PBX1 as prognostic marker

Patrick Sven Plum, Timo Hess, Denis Bertrand, Isabelle Morgenstern et autres

BACKGROUND: Cholangiocarcinoma (CCA) is a fatal cancer of the bile duct with a poor prognosis owing to limited therapeutic options. The incidence of intrahepatic CCA (iCCA) is increasing worldwide, and its molecular basis is emerging. Environmental factors may contribute to regional differences …

de, sg, ro, ch (code pays fourni par la source)

Supplementary text from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

Supplementary text that describes parameters used for driver prediction methods and analysis of machine learning approaches for consensus generation.

Supplementary table 3 from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

List of PIK3CA oncogenic mutations

Supplementary table 2 from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

List of actionable genes

Supplementary table 3 from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

List of PIK3CA oncogenic mutations

Supplementary table 2 from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

List of actionable genes

Data from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

Abstract Existing cancer driver prediction methods are based on very different assumptions and each of them can detect only a particular subset of driver genes. Here we perform a comprehensive assessment of 18 driver prediction methods on more than 3,400 tumor samples …

Supplementary figure from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

Supplementary figures showing additional comparisons and benchmarks for ConsensusDriver.

Supplementary text from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

Supplementary text that describes parameters used for driver prediction methods and analysis of machine learning approaches for consensus generation.

Supplementary table 1 from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

List of cancer diver genes and passenger genes

Supplementary table 1 from ConsensusDriver Improves upon Individual Algorithms for Predicting Driver Alterations in Different Cancer Types and Individual Patients

Denis Bertrand, Sibyl Drissler, Burton Kuan Hui Chia, Jia Yu Koh et autres

List of cancer diver genes and passenger genes