Christina Coughlan

Analysis of Neuron-derived Blood Exosomes in Anti-n-methyl-d-aspartate Receptor Encephalitis and Neuropsychiatric Lupus (P8-1.007)

Ryan Kammeyer, Kimberly Chapman, Jennifer Cooper, Susan Boackle et autres

To identify novel minimally invasive biomarkers of disease for anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) and neuropsychiatric lupus (NPSLE) using neuron-derived blood exosomes.

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Relation of blood-based inflammation conditional networks to key immune health status and Alzheimer’s biomarkers in aging adults

Brianne M. Bettcher, Siyang Ren, Yue Wang, Nichole E. Carlson et autres

Blood inflammatory marker studies in aging and Alzheimer's disease (AD) research have faced numerous interpretative and methodological challenges that have hindered the field's understanding of the relationship between immune network regulation/dysregulation and aging health factors. We examined how blood inflammation markers directly …

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CNS-compartmentalized IgG aggregates and glycosylation in multiple sclerosis contribute to oligoclonal bands and neuronal cytotoxicity

Sakthi Asokan, Wenbo Zhou, Anthony Fringuello, Tiffany Pointon et autres

Background: Oligoclonal bands (OCBs) are a hallmark of multiple sclerosis (MS), yet their molecular characteristics and pathogenic relevance remain incompletely understood. Recent evidence suggests that immunoglobulin G (IgG) aggregates and glycosylation may contribute to neuroinflammation and neuronal injury in MS. Methods: We …

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Blood measure of neuronal death is exponentially higher with age, especially in females, and halted in Alzheimer’s disease by GM-CSF treatment

Stefan Sillau, Christina Coughlan, Md. Mahiuddin Ahmed, Kavita Nair et autres

Aging increases the risk of neurodegeneration, cognitive decline, and Alzheimer's disease (AD). We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers …

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A Fluorescence Resonance Energy Transfer-Based Assay Targeting Tumor-Derived Extracellular Vesicles for Highly Specific Pancreatic Cancer Detection

Alfred Akinlalu, Komila Rasuleva, Emmanuel Ogberefor, Tommy Gao et autres

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging cancers to detect, with significant limitations compared to screening methods for lung, breast, colon, and cervical cancers. Current methods are often plagued by high false-positive rates, necessitating costly, complex, and invasive confirmatory …

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From Bench to Bedside: New Frontiers in Understanding and Treating Postoperative Delirium

Kenneth Meza Monge, Allison Shapiro, Christina Coughlan, Benedetto Mungo et autres

Postoperative delirium is a frequent and serious neurocognitive complication in older surgical patients, characterized by acute impairments in attention, awareness, and cognition. It is associated with increased morbidity, prolonged hospitalization, and persistent cognitive decline. In this narrative review, we synthesize translational research …

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Obese adipose tissue-derived extracellular vesicles enriched with glycolytic cargo promote colorectal cancer tumorigenesis

Parsa Haque, Shere L. Paris, Rhonda F. Souza, Joseph C. Onyiah et autres

Obesity increases the risk of colorectal cancer (CRC) development, accelerates disease progression and is associated with decreased disease-free survival. Obesity adversely affects the visceral adipose tissue (VAT) leading to increased secretion of extracellular vesicles (EVs). However, the crosstalk between VAT and CRC …

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Effects of sodium bicarbonate therapy on cognitive and cerebrovascular function in midlife and older adults with chronic kidney disease: a pilot randomized trial

Fei Gu, Zhiying You, N. Hawkins, Rachael Reddin et autres

Metabolic acidosis may create a pathway to cognitive impairment in chronic kidney disease (CKD) by contributing to cerebrovascular dysfunction. Trials examining the effect of sodium bicarbonate (NaHCO 3 ) on cognitive function are lacking. We conducted a randomized, double-blind, placebo-controlled pilot study …

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Epigenetic dysregulation of transposable elements in cognitive impairment and Alzheimer’s disease

Alyssa N. Cavalier, M. Smith, Gabriella T. McWilliams, Cali M. McEntee et autres

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Circulating Interleukin‐6 Levels and Timing of Acute Ischemic Stroke Onset

Robert G. Kowalski, Aurélie Ledreux, John Violette, Whitney Paustian et autres

Intravenous thrombolysis is the most widely available effective ischemic stroke treatment, but is approved only if given within 4.5 h from stroke onset. Many patients are not treated because stroke onset time is unknown. We evaluated the cytokine interleukin 6 (IL-6) in …

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0094 Impact of Insufficient Sleep on Biomarkers of Neurodegeneration and Neuroinflammation in Healthy Adults

Erin E. Kishman, Brice V. McConnell, Corey A. Rynders, Lauren Smith et autres

Abstract Introduction Sleep disturbances are common among individuals with neurodegenerative diseases including Alzheimer’s Disease (AD). Furthermore, sleep disturbances are associated with accelerated cognitive decline and an increased risk of developing AD. Here we examined the impact of four nights of insufficient sleep …

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Abstract WP348: Inflammatory biomarkers in the Golden Hour: findings from a Mobile Stroke Unit

Aurélie Ledreux, John Violette, Robert Neumann, John A. Thompson et autres

Background: The intervention of mobile stroke units (MSUs) on a patient experiencing an acute ischemic stroke significantly improves outcomes compared to standard of care provided by emergency medical services. It allows for more patients to be treated with intravenous thrombolysis during the …

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