Stefan Siebert

Re-evaluation of characters in Apolemiidae (Siphonophora), with description of two new species from Monterey Bay, California

Stefan Siebert, Phil Pugh, Steven H. D. Haddock, Casey W. Dunn

Re-evaluation of characters in Apolemiidae (Siphonophora), with description of two new species from Monterey Bay, California

Stefan Siebert, Phil Pugh, Steven H. D. Haddock, Casey W. Dunn

High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein

Marion Lechable, Xuechen Tang, Stefan Siebert, Angelika Feldbacher et autres

The proto-oncogene myc has been intensively studied primarily in vertebrate cell culture systems. Myc transcription factors control fundamental cellular processes such as cell proliferation, cell cycle control and stem cell maintenance. Myc interacts with the Max protein and Myc/Max heterodimers regulate thousands …

at, us (code pays fourni par la source)

Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells

Naritaka Tamaoki, Stefan Siebert, Takuya Maeda, Ngoc‐Han Ha et autres

Although the differentiation of human induced pluripotent stem cells (hiPSCs) into various types of blood cells has been well established, approaches for clinical-scale production of multipotent hematopoietic progenitor cells (HPCs) remain challenging. We found that hiPSCs cocultured with stromal cells as spheroids …

us, jp (code pays fourni par la source)

A chromosome-scale epigenetic map of the Hydra genome reveals conserved regulators of cell state

Jack F. Cazet, Stefan Siebert, Hannah Morris Little, Philip Bertemes et autres

The epithelial and interstitial stem cells of the freshwater polyp Hydra are the best-characterized stem cell systems in any cnidarian, providing valuable insight into cell type evolution and the origin of stemness in animals. However, little is known about the transcriptional regulatory …

us, at (code pays fourni par la source)

New Hydra genomes reveal conserved principles of hydrozoan transcriptional regulation

Jack F. Cazet, Stefan Siebert, Hannah Morris Little, Philip Bertemes et autres

Abstract The epithelial and interstitial stem cells of the freshwater polyp Hydra are the best characterized stem cell systems in any cnidarian, providing valuable insight into cell type evolution and the origin of stemness in animals. However, little is known about the …

us, at (code pays fourni par la source)

Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary

Yulong Liu, Michelle E. Kossack, Matthew E. McFaul, Lana N Christensen et autres

Zebrafish are an established research organism that has made many contributions to our understanding of vertebrate tissue and organ development, yet there are still significant gaps in our understanding of the genes that regulate gonad development, sex, and reproduction. Unlike the development …

us (code pays fourni par la source)

Author response: Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary

Yulong Liu, Michelle E. Kossack, Matthew E. McFaul, Lana N Christensen et autres

Single-cell transcriptomics of the zebrafish ovary identifies both major and minor cell types and provides a valuable resource for researchers interested in reproductive biology, stem cell biology, and aquatic toxicology.

us (code pays fourni par la source)

Evolution of Gene Expression across Species and Specialized Zooids in Siphonophora

Catriona Munro, Felipe Zapata, Mark Howison, Stefan Siebert et autres

Siphonophores are complex colonial animals, consisting of asexually produced bodies (zooids) that are functionally specialized for specific tasks, including feeding, swimming, and sexual reproduction. Though this extreme functional specialization has captivated biologists for generations, its genomic underpinnings remain unknown. We use RNA-seq …

us (code pays fourni par la source)

Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary

Yulong Liu, Michelle E. Kossack, Matthew E. McFaul, Lana N Christensen et autres

Abstract Zebrafish are an established research organism that has made many contributions to our understanding of vertebrate tissue and organ development, yet there are still significant gaps in our understanding of the genes that regulate gonad development, sex, and reproduction. Unlike the …

us (code pays fourni par la source)

Evolution of gene expression across species and specialized zooids in Siphonophora

Catriona Munro, Felipe Zapata, Mark Howison, Stefan Siebert et autres

Abstract Background Siphonophores are complex colonial animals, consisting of asexually-produced bodies (called zooids) that are functionally specialized for specific tasks, including feeding, swimming, and sexual reproduction. Though this extreme functional specialization has captivated biologists for generations, its genomic underpinnings remain unknown. We …

fr, us (code pays fourni par la source)

Differential gene regulation in DAPT-treated Hydra reveals candidate direct Notch signalling targets

Jasmin Moneer, Stefan Siebert, Stefan Krebs, Jack F. Cazet et autres

In Hydra, Notch inhibition causes defects in head patterning and prevents differentiation of proliferating nematocyte progenitor cells into mature nematocytes. To understand the molecular mechanisms by which the Notch pathway regulates these processes, we performed RNA-seq and identified genes that are differentially …

de, us (code pays fourni par la source)