Marion Steger

»Zwischen Aphrodite-Tempel und spätarchaischem Haus.« Die Innsbrucker Kampagne 2011 auf dem Monte Iato (Sizilien). Jahreshefte des Österreichischen Archäologischen Institutes in Wien|Band 82/2013 82|

Erich Kistler, Birgit Öhlinger, Marion Steger

Around 500 B.C., a large, two-storey house was constructed on Monte Iato. This building is oriented along br/a sacral axis, which formed the foundation of the Aphrodite Temple, constructed 550 B.C. The upper level br/of this late archaic building housed decorated banqueting …

Clonal Hematopoiesis of Indeterminate Potential and Diabetic Kidney Disease: A Nested Case-Control Study

Sara Denicolò, Verena Vogi, Felix Keller, Stefanie Thöni et autres

Introduction: The disease trajectory of diabetic kidney disease (DKD) shows a high interindividual variability not sufficiently explained by conventional risk factors. Clonal hematopoiesis of indeterminate potential (CHIP) is a proposed novel cardiovascular risk factor. Increased kidney fibrosis and glomerulosclerosis were described in …

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Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

Wilfried Posch, Marta Bermejo‐Jambrina, Marion Steger, Christina Witting et autres

Importantly, our study highlights an unusual target on DCs-the α chain of complement receptor 4 (CR4) (CD11c)-for therapeutic interventions in HIV-1 treatment. Targeting CD11c on DCs mediated a potent antiviral immune response via clustering of CR4 and CCR5 and subsequent opening of …

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Chemical profiling of the traditional Chinese herbal formula Fang Feng Tong Sheng Wan by ultrahigh-performance liquid chromatography/orbitrap mass spectrometry / Marion Steger

Marion Steger

β-1,3-glucan-lackingAspergillus fumigatusmediates an efficient antifungal immune response by activating complement and dendritic cells

Marion Steger, Marta Bermejo‐Jambrina, Teodor E. Yordanov, Johannes Wagener et autres

Complement system and dendritic cells (DCs) form – beside neutrophils and macrophages – the first line of defense to combat fungal infections. Therefore, we here studied interactions of these first immune elements with Aspergillus fumigatus lacking ß-1,3-glucans (fks1tetOnrep under repressed conditions) to …

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β-1,3-glucan-lacking Aspergillus fumigatus mediates an efficient antifungal immune response by activating complement and dendritic cells

Marion Steger, Marta Bermejo‐Jambrina, Teodor E. Yordanov, Johannes Wagener et autres

Complement system and dendritic cells (DCs) form – beside neutrophils and macrophages – the first line of defense to combat fungal infections. Therefore, we here studied interactions of these first immune elements with Aspergillus fumigatus lacking ß-1,3-glucans (fks1tetOnrep under repressed conditions) to …

β-1,3-glucan-lacking Aspergillus fumigatus mediates an efficient antifungal immune response by activating complement and dendritic cells

Marion Steger, Marta Bermejo‐Jambrina, Teodor E. Yordanov, Johannes Wagener et autres

Complement system and dendritic cells (DCs) form – beside neutrophils and macrophages – the first line of defense to combat fungal infections. Therefore, we here studied interactions of these first immune elements with Aspergillus fumigatus lacking ß-1,3-glucans (fks1tetOnrep under repressed conditions) to …

Fast-track development of an in vitro 3D lung/immune cell model to study Aspergillus infections

Parul Chandorkar, Wilfried Posch, Viktoria Zaderer, Michael Blatzer et autres

To study interactions of airborne pathogens, e.g. Aspergillus (A.) fumigatus with upper and lower respiratory tract epithelial and immune cells, we set up a perfused 3D human bronchial and small airway epithelial cell system. Culturing of normal human bronchial or small airway …

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Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance

Emina Jukic, Michael Blatzer, Wilfried Posch, Marion Steger et autres

ABSTRACT In this study, we characterize the impact of antioxidative enzymes in amphotericin B (AmB)-resistant (ATR) and rare AmB-susceptible (ATS) clinical Aspergillus terreus isolates. We elucidate expression profiles of superoxide dismutase (SOD)- and catalase (CAT)-encoding genes, enzymatic activities of SODs, and superoxide …

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Promising immunotherapy against fungal diseases

Wilfried Posch, Marion Steger, Doris Wilflingseder, Cornelia Lass‐Flörl

INTRODUCTION: Despite the relatively high efficacy of antifungal drugs, invasive fungal infections (IFIs) are still associated with tremendous morbidity and mortality, since late diagnosis makes an antifungal drug therapy inefficient. Therefore, antifungal immunotherapies to specifically strengthen the host´s own immune mechanisms constitute …

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La Tomba dei Guerrieri a Montagna di Marzo alla luce della diffusione delle ‘iscrizioni parlanti’ in Sicilia dall’ età arcaica alla prima metà del V sec. a. C.

Marion Steger

Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells

Wilfried Posch, Marion Steger, Ulla Knackmuss, Michael Blatzer et autres

DCs express intrinsic cellular defense mechanisms to specifically inhibit HIV-1 replication. Thus, DCs are productively infected only at very low levels with HIV-1, and this non-permissiveness of DCs is suggested to go along with viral evasion. We now illustrate that complement-opsonized HIV-1 …

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