Accès ouvert
2024
article
OpenAlex
Ju Hee Lee, Jie Yao, A.C. Morrison, Brian E. Cade et autres
Background: Alcohol intake influences plasma lipid levels, and such effects may be moderated by genetic variants. We aimed to characterize the role of aggregated rare and low-frequency protein-coding variants in gene by alcohol consumption interactions associated with fasting plasma lipid levels. Methods: …
Accès ouvert
2022
article
OpenAlex
D.O. Arnar, E.A. Whitsel, J.W. Jukema, A.P. Reiner et autres
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 …
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Accès ouvert
2022
article
OpenAlex
E.A. Whitsel, T. Meitinger, R.B. Schnabel, Alexander Teumer et autres
The P wave on an ECG is a measure of atrial electric function, and its characteristics may serve as predictors for atrial arrhythmias. Increased mean P-wave duration and P-wave terminal force traditionally have been used as markers for left atrial enlargement, and …
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