Whitney Fields

Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study

Zoe Swank, Ella Borberg, Yulu Chen, Yasmeen Senussi et autres

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Characterizing Long COVID in Children and Adolescents

Rachel S. Gross, Tanayott Thaweethai, Lawrence C. Kleinman, Jessica Snowden et autres

Importance: Most research to understand postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, has focused on adults, with less known about this complex condition in children. Research is needed to characterize pediatric PASC to enable studies of underlying mechanisms that will …

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Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort

Kristine M. Erlandson, Caitlin Selvaggi, Tanayott Thaweethai, Peter Chen et autres

BACKGROUND: There are currently no validated clinical biomarkers of postacute sequelae of SARS-CoV-2 infection (PASC). OBJECTIVE: To investigate clinical laboratory markers of SARS-CoV-2 and PASC. DESIGN: Propensity score-weighted linear regression models were fitted to evaluate differences in mean laboratory measures by prior …

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4 Black and Puerto Rican Student Experiences and Their Movements at Douglass College, 1945–1974

Kaisha Esty, Whitney Fields, Carie Rael

Interactions involved in pH protection of the alphavirus fusion protein

Whitney Fields, Margaret Kielian

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NEWS AND CIVIC LITERACY;WHAT’S THE CONNECTION?

Whitney Fields, Rachel Thelin, Sheila Suess Kennedy

The Role of E3 in pH Protection during Alphavirus Assembly and Exit

Onyinyechukwu Uchime, Whitney Fields, Margaret Kielian

Alphaviruses are small enveloped viruses whose surface is covered by spikes composed of trimers of E2/E1 glycoprotein heterodimers. During virus entry, the E2/E1 dimer dissociates within the acidic endosomal environment, freeing the E1 protein to mediate fusion of the viral and endosome …

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Cross-Inhibition of Chikungunya Virus Fusion and Infection by Alphavirus E1 Domain III Proteins

Claudia Sánchez-San Martín, Soumya Nanda, Yan Zheng, Whitney Fields et autres

Alphaviruses are small enveloped RNA viruses that include important emerging human pathogens, such as chikungunya virus (CHIKV). These viruses infect cells via a low-pH-triggered membrane fusion reaction, making this step a potential target for antiviral therapies. The E1 fusion protein inserts into …

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A Key Interaction between the Alphavirus Envelope Proteins Responsible for Initial Dimer Dissociation during Fusion

Whitney Fields, Margaret Kielian

Alphaviruses such as Semliki Forest virus (SFV) are enveloped viruses whose surface is covered by an organized lattice composed of trimers of E2-E1 heterodimers. The E1 envelope protein, a class II fusion protein, contains the hydrophobic fusion loop and refolds to drive …

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