Traude H. Beilharz

Candida auris uses nutrient sensing to modulate virulence and host immune responses

Irma Tedja, Harshini Weerasinghe, Garrett Bryak, Helen Stölting et autres

The emergence of Candida auris as a pathogen required host adaptation and evasion of mammalian immunity, but the mechanisms are poorly understood. We discovered that C. auris uses nutrient sensing to tune its virulence traits and modulate immune activation in changing environments. …

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Metastasis of triple negative breast cancer is regulated by a targetable miR-342-E2F network

Victoria Kiriaki Arnet, Cameron N. Johnstone, Richard P. Redvers, Caroline A. Chambers et autres

Triple-negative breast cancer (TNBC) has a high incidence of metastasis and limited therapeutic options. Here, we identify a multimodal and targetable miR-342-E2F network that regulates metastatic outgrowth in TNBC. Through integrating clinical and experimental datasets, we uncover miR-342 as a suppressor of …

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A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition

Manasa Bharathwaj, Vinzenz Hofferek, Angavai Swaminathan, Rachael Emily Turner et autres

Fungi transition between cell morphologies to adapt to and colonize environments. For Candida albicans, commensal colonization of humans and virulence depend on a reversible switch between invasive hyphae and disseminating yeast cells. The yeast-to-hyphae transition is well understood, but comparatively little is …

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Short chain fatty acids potentiate azoles by reprogramming fungal acetyl-CoA metabolism

Christopher McCrory, Sofya Rabinovich, Harshini Chamindri Weerasinghe, Tricia L. Lo et autres

ABSTRACT Pathogens colonise metabolically diverse host environments. How metabolites found in host environments regulate antimicrobial drug susceptibility remains to be fully understood. Here we report on the roles of gut metabolites, short chain fatty acids (SCFAs), in antifungal drug susceptibility of the …

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Candida auris uses nutrient sensing to titrate its virulence potential and modulate immune response for host colonisation

Irma Tedja, Harshini Weerasinghe, Garrett Bryak, Aysha L. Sezmis et autres

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The transcriptomic signature of age and sex is not conserved in human primary myocytes

Séverine Lamon, Megan Soria, Ross D. Williams, Annabel J. Critchlow et autres

Abstract Background Human primary muscle cell (HPMC) lines derived from skeletal muscle biopsies are potentially powerful tools to interrogate the molecular pathways underlying fundamental muscle mechanisms. HPMCs retain their genome in culture, but many endogenous circulating factors are not present in the …

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Human primary myotubes and immortalised C2C12 Cells display inconsistent metabolic gene expression and alternative polyadenylation during differentiation.

Akriti Varshney, Paul F. Harrison, Angavai Swaminathan, Sarah E. Alexander et autres

Data supplementing the manuscript submitted to AJP - Cell.

Human primary myotubes and immortalised C2C12 Cells display inconsistent metabolic gene expression and alternative polyadenylation during differentiation.

Akriti Varshney, Paul F. Harrison, Angavai Swaminathan, Sarah E. Alexander et autres

Data supplementing the manuscript submitted to AJP - Cell.

Human primary myotubes and immortalised C2C12 Cells display inconsistent metabolic gene expression and alternative polyadenylation during differentiation.

Akriti Varshney, Paul F. Harrison, Angavai Swaminathan, Sarah E. Alexander et autres

Data supplementing the manuscript submitted to AJP - Cell.

The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking

Daniel Neumann, Katherine A. Pillman, B. Kate Dredge, Andrew G. Bert et autres

Epithelial-mesenchymal transition (EMT) plays important roles in tumour progression and is orchestrated by dynamic changes in gene expression. While it is well established that post-transcriptional regulation plays a significant role in EMT, the extent of alternative polyadenylation (APA) during EMT has not …

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The landscape of alternative polyadenylation during EMT and its regulation by the RNA-binding protein Quaking

Daniel Neumann, Katherine A. Pillman, B. Kate Dredge, Andrew G. Bert et autres

Epithelial-mesenchymal transition (EMT) plays important roles in tumour progression and is orchestrated by dynamic changes in gene expression. While it is well established that post-transcriptional regulation plays a significant role in EMT, the extent of alternative polyadenylation (APA) during EMT has not …

Primary human myoblasts display only minor alternative polyadenylation compared to the transformed C 2 C 12 model of muscle differentiation

Akriti Varshney, Paul F. Harrison, Angavai Swaminathan, Sarah E. Alexander et autres

Abstract Alternative polyadenylation has been linked to multiple developmental and disease transitions. The prevailing hypothesis being that differentiated cells use longer 3’ UTRs with expended regulatory capacity whereas undifferentiated cells use shorter 3’ UTRs. Here, we describe the gene expression and alternative …

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