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Cynthia C. Liu, Qiuhan Huang, Evan D. Shaulson, Caroline Trumpff et autres
To survive and thrive, living organisms must monitor and regulate cell-level energy supply, demand, and transformation. Metabolic energy is monitored through a set of brain-directed interoceptive processes we refer to as metaboception. Here, we review evidence for a specific metaboceptive signaling cascade …
Janell L.M. Smith, Kamaryn Tanner, Jack Devine, Anna S. Monzel et autres
Abstract Mitochondrial stress activates the integrated stress response (ISR) and triggers cell–cell communication through the secretion of the metabokine growth differentiation factor 15 (GDF15). However, the gene network underlying the ISR remains poorly defined, particularly across metabolically diverse cellular states and tissues. …
us (code pays fourni par la source)
Janell L.M. Smith, Kamaryn Tanner, Jack Devine, Anna S. Monzel et autres
Abstract Mitochondrial stress activates the integrated stress response (ISR) and triggers cell–cell communication through the secretion of the metabokine growth differentiation factor 15 (GDF15). However, the gene network underlying the ISR remains poorly defined across metabolically diverse cellular states and tissues. Using …
Lisa Månsson, Ethan Dickson, Lun Hao, Angela Pitenis et autres
The integrated stress response (ISR) is a highly conserved signaling network, allowing cells to adapt and respond to various stressors. With its aggressive spread and high recurrence rates, glioblastoma multiforme (GBM) is one of the toughest cancers to date, yet the role …
us (code pays fourni par la source)
Lisa K. Månsson, Hao Li, Angela A. Pitenis, Maxwell Z. Wilson
The integrated stress response (ISR) is a highly conserved signaling network, allowing cells to adapt and respond to various stressors. With its aggressive spread and high recurrence rates, glioblastoma multiforme (GBM) is one of the toughest cancers to date, yet the role …
us (code pays fourni par la source)
Joseph Rufo, Chongxu Qiu, Dasol Han, Naomi Baxter et autres
Gastrulation, a critical developmental stage involving germ layer specification and axes formation, is a major point of failure in human development, contributing to pregnancy loss and congenital malformations. However, due to ethical constraints and anatomical differences in animal models, the failure modes …
us (code pays fourni par la source)
Olivier Witteveen, Samuel J Rosen, Ryan S. Lach, Maxwell Z. Wilson et autres
Populations of cells regulate gene expression in response to external signals, but their ability to make reliable collective decisions is limited by both intrinsic noise in molecular signaling and variability between individual cells. In this work, we use optogenetic control of the …
nl, us (code pays fourni par la source)
Samuel J Rosen, Olivier Witteveen, Naomi Baxter, Ryan S. Lach et autres
Cells process dynamic signaling inputs to regulate fate decisions during development. While oscillations or waves in key developmental pathways, such as Wnt, have been widely observed, the principles governing how cells decode these signals remain unclear. By leveraging optogenetic control of the …
us, nl (code pays fourni par la source)
Samuel J Rosen, Olivier Witteveen, Naomi Baxter, Ryan S. Lach et autres
Human cells decode dynamics Wnt signals using an anti-resonant filter that suppresses intermediate-frequency inputs and is capable of redirecting developmental fate outcomes, including germ-layer specification.
us, nl (code pays fourni par la source)
Naomi J. Baxter, Robert A. Piscopio, Joseph Rufo, Dasol Han et autres
Embryonic cells must interpret morphogen signals that vary in both time and space, but the rules by which they decode these dynamics remain unclear. Here we combine optogenetics with human 2D gastruloids to define minimal WNT signaling rules for germ-layer patterning. We …
us (code pays fourni par la source)
Samuel J Rosen, Olivier Witteveen, Naomi J. Baxter, Ryan S. Lach et autres
Cells process dynamic signaling inputs to regulate fate decisions during development. While oscillations or waves in key developmental pathways, such as Wnt, have been widely observed, the principles governing how cells decode these signals remain unclear. By leveraging optogenetic control of the …
Samuel J Rosen, Olivier Witteveen, Naomi J. Baxter, Ryan S. Lach et autres
Cells process dynamic signaling inputs to regulate fate decisions during development. While oscillations or waves in key developmental pathways, such as Wnt, have been widely observed, the principles governing how cells decode these signals remain unclear. By leveraging optogenetic control of the …
us, nl (code pays fourni par la source)
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