Hiroyasu Mori

Clinical characteristics of Sarcopenic obesity in Japanese people with type 2 diabetes: A post hoc analysis of the sub‐cohort iDIAMOND study

Hiroyasu Mori, Kasei Ko, Satoko Notomi, Sumiko Yoshida et autres

AIMS/INTRODUCTION: Sarcopenic obesity, defined by reduced muscle mass and strength with excess adiposity, is poorly characterized in Japanese individuals with type 2 diabetes (T2D). This post hoc analysis assessed its prevalence and associations with physical quality of life (QOL), walking ability, and …

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Telenutrition Education Is Effective for Glycemic Management in People with Type 2 Diabetes Mellitus: A Non-Inferiority Randomized Controlled Trial in Japan

Hiroyasu Mori, Satoshi Taniguchi, Yu Tamaki, Motoyuki Tamaki et autres

This study examined the non-inferior efficacy of telenutrition education compared with face-to-face nutrition education in managing glycemic control in people with type 2 diabetes mellitus (T2DM). Participants had T2DM and a glycated hemoglobin (HbA1c) ranged 6.5–9.5%. Thirty participants were randomly assigned to …

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Dehydroepiandrosterone Sulfate, an Adrenal Androgen, Is Inversely Associated with Prevalence of Dynapenia in Male Individuals with Type 2 Diabetes

Saya Yasui, Yousuke Kaneko, Hiroki Yamagami, Minae Hosoki et autres

Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging. Although skeletal muscle disorders are often found in diabetic people, the clinical significance of DHEAS in skeletal muscle remains unclear. Therefore, we aimed to determine whether DHEAS is associated …

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Umami taste sensitivity is associated with food intake and oral environment in subjects with diabetes

Ayuka Kawakami, Mika Bando, Tomoe Takashi, Mizuki Sugiuchi et autres

OBJECTIVE: Dysgeusia is a serious problem in patients with diabetes because it often leads to overeating, which is associated with disease progression. This study aimed to investigate the association between taste sensitivity, eating habits, and the oral environment. SUBJECTS AND METHODS: In …

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Molecular composition of adiponectin in urine is a useful biomarker for detecting early stage of diabetic kidney disease

Tomoharu Kawano, Motohiro Aiba, Masashi Ishizu, Hiroyasu Mori et autres

We previously developed two immune complex transfer enzyme immunoassays (ICT-EIA) to measure total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) in urine and have verified their usefulness as biomarkers for diabetic kidney disease. In this study, we developed T-AN and H-AN …

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De-Training Effects Following Leucine-Enriched Whey Protein Supplementation and Resistance Training in Older Adults with Sarcopenia: A Randomized Controlled Trial with 24 Weeks of Follow-Up

Hiroyasu Mori, Yasunobu Tokuda

OBJECTIVES: This study aimed to evaluate the effectiveness of de-training after a combined intervention of leucine-enriched whey protein supplementation and resistance training on skeletal muscle mass and strength in older adults with sarcopenia. DESIGN: A randomized controlled trial. SETTING: A community in …

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Clinical features and lipid profiles of plaque erosion over lipid rich plaque versus fibrous plaque

Teruo Sekimoto, Hiroyasu Mori, Shinji Koba, H Suzuki et autres

Abstract Backgrounds and aims Plaque erosion (PE) which is one of the most common causes of acute coronary syndrome (ACS) can occur over fibrous plaque or lipid-rich plaque (LRP) according to pathological reports. Whereas in plaque rupture (PR) the main cause of …

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Chronic Intake of a Meal Including Alaska Pollack Protein Increases Skeletal Muscle Mass and Strength in Healthy Older Women: A Double-Blind Randomized Controlled Trial

Hiroyasu Mori, Yasunobu Tokuda, Eriko Yoshida, Kenji Uchida et autres

BACKGROUND: In animal studies, a meal containing Alaska pollack protein (APP) induces fast-twitch muscle hypertrophy. To our knowledge, no interventional studies have examined the benefits of APP intake on muscle mass and muscle weakness and the prevention of sarcopenia in older individuals. …

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Novel method utilizing bisulfite conversion with dual amplification‐refractory mutation system polymerase chain reaction to detect circulating pancreatic β‐cell cfDNA

Asami Okada, Misuzu Yamada‐Yamashita, Yukari Tominaga, Kyoka Jo et autres

AIMS/INTRODUCTION: Several research groups have reported methods for quantifying pancreatic beta cell (β-cell) injury by measuring β-cell-specific CpG unmethylation of the insulin gene in circulation using digital droplet PCR or next-generation sequencing. However, these methods have certain disadvantages, such as the need …

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Essential Amino Acid and Tea Catechin Supplementation after Resistance Exercise Improves Skeletal Muscle Mass in Older Adults with Sarcopenia: An Open-Label, Pilot, Randomized Controlled Trial

Yasunobu Tokuda, Hiroyasu Mori

Tea catechins (TCCs) have gained significant attention owing to their health effects. However, evidence is limited regarding the benefit of TCC and essential amino acids (EAAs) ingestion plus that of TCC ingestion after resistance exercise (RE) among older individuals with sarcopenia. We …

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Taste receptor gene expression is associated with decreased eGFR in patients with diabetes

Kana Beppu, Ayuka Kawakami, Yuna Mishima, Rie Tsutsumi et autres

Dysgeusia is not only associated with zinc deficiency but also with certain drugs or diseases, including diabetes and renal failure. It often lowers the patient's quality of life and hinders access to proper nutrition. The underlying mechanism is unclear and there is …

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A low serum IGF-1 is correlated with sarcopenia in subjects with type 1 diabetes mellitus: Findings from a post-hoc analysis of the iDIAMOND study

Sonyun Hata, Hiroyasu Mori, Tetsuyuki Yasuda, Yoko Irie et autres

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