Hengshuai Zhang

Decreased autophagic activity of detrusor cells is involved in the inflammatory response of interstitial cystitis/bladder pain syndrome

Jiang Zhao, Qudong Lu, Zhengxin Yang, Bishao Sun et autres

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Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome

Jiang Zhao, Shan Chen, Chengfei Yang, Mi Zhou et autres

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Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization.

Hengshuai Zhang, Xingyou Dong, Zhenxing Yang, Qudong Lu et autres

BACKGROUND: Cross-sensitization of pelvic organs is one theory for why symptoms of gut sickness and interstitial cystitis/bladder pain syndrome overlap. Experimental colitis has been shown to trigger bladder hyperactivity and hyperalgesia in rats. The chemokine receptor CXCR4 plays a key role in …

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Inhibition of CXCR4 in Spinal Cord and DRG with AMD3100 Attenuates Colon-Bladder Cross-Organ Sensitization

Hengshuai Zhang, Xingyou Dong, Zhenxing Yang, Jiang Zhao et autres

Hengshuai Zhang, Xingyou Dong, Zhenxing Yang, Jiang Zhao, Qudong Lu, Jingzhen Zhu, Longkun Li, Shanhong Yi, Jie Xu Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037, People’s Republic of ChinaCorrespondence: Jie Xu; Shanhong YiDepartment of Urology, Second Affiliated Hospital, …

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Activation of CXCL13/CXCR5 Axis Aggravates Experimental Autoimmune Cystitis and Interstitial Cystitis/Bladder Pain Syndromeactivation of Cxcl13/Cxcr5 Axis Aggravates Experimental Autoimmune Cystitis and Interstitial Cystitis/Bladder Pain Syndrome

Jiang Zhao, Shan chen, Chengfei Yang, Mi Zhou et autres

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Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF-κB Pathways

Hengshuai Zhang, Jiang Zhao, Qudong Lu, Bishao Sun et autres

Hemorrhagic cystitis is an important complication of cyclophosphamide chemotherapy, and current therapies for the disease are limited. The natural flavonoid luteolin (LUT) has significant anti-inflammatory and antioxidant properties, but its protective effect on cyclophosphamide (CYP)-induced bladder toxicity has yet to be evaluated. …

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Activation of GPR18 by Resolvin D2 Relieves Pain and Improves Bladder Function in Cyclophosphamide-Induced Cystitis Through Inhibiting TRPV1

Qudong Lu, Yang Yang, Hengshuai Zhang, Cheng Chen et autres

PURPOSE: Hyperalgesia and bladder overactivity are two main symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS). Cannabinoid receptors participate in the modulation of pain and bladder function. GPR18, a member of the cannabinoid receptor family, also participates in the regulation of pain and …

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Estrogen inhibits bladder overactivity in rats with cyclophosphamide‐induced cystitis via downregulating the expression of P2X3 receptors in bladder epithelium cells

Xin Liu, Yang Yang, Ye Gao, Hengshuai Zhang et autres

AIMS: The therapeutic effect of estrogen on interstitial cystitis/bladder pain syndrome is unclear. We aim to explore the effect of estrogen on bladder overactivity in rats with cyclophosphamide-induced cystitis and its underlying mechanism. METHODS: In vivo cystometry was used to determine the …

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Increased transient receptor potential canonical 3 activity is involved in the pathogenesis of detrusor overactivity by dynamic interaction with Na+/Ca2+ exchanger 1

Jingzhen Zhu, Fan Yi, Qudong Lu, Yang Yang et autres

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Suppression of adenosine A2a receptors alleviates bladder overactivity and hyperalgesia in cyclophosphamide-induced cystitis by inhibiting TRPV1

Yang Yang, Hengshuai Zhang, Qudong Lu, Xin Bo Liu et autres

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