Daniel Hargbøll Madsen

Dual targeting of CCR2 + monocytes and neutrophils enhances anti-tumor immunity

Klaire Yixin Fjæstad, Astrid Zedlitz Johansen, Hannes Linder, Marco Carretta et autres

ABSTRACT Targeting immunosuppressive tumor-associated myeloid populations has emerged as a promising strategy to enhance anti-tumor immunity. The CCL2–CCR2 axis plays a central role in the recruitment of monocytes that differentiate into tumor-associated macrophages (TAMs), yet the therapeutic potential of CCR2 targeting remains …

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Acquired resistance to immune checkpoint inhibitors is associated with hypoxia and ECM remodeling in colorectal cancer

Astrid Zedlitz Johansen, Hannes Linder, Cecilie Oelvang Madsen, Kevin James Baker et autres

Acquired resistance to immune checkpoint inhibitors (ICIs) limits the durability of therapeutic responses across multiple cancer types, yet the underlying mechanisms remain poorly defined. Using the murine MC38 colorectal cancer model, we established an in vivo model recapitulating clinical response patterns, including …

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O11.02 β-adrenergic blockade unleashes cytotoxic CD4 T cell immunity in cancer

Klaire Yixin Fjæstad, Niels Junker, Per thor Straten, Daniel Hargbøll Madsen

Background β-adrenergic signaling has been implicated in tumor progression and immune suppression, and epidemiological and clinical observations suggest potential anti-cancer benefits of β-blockers. Propranolol, a widely prescribed nonselective β-blocker, has recently demonstrated clinical efficacy in vascular sarcomas; however, the anti-tumorigenic mechanisms underlying …

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Collagen type I promotes pancreatic tumor growth and limits immune cell infiltration

Marie‐Louise Thorseth, Astrid Zedlitz Johansen, Kevin James Baker, Marco Carretta et autres

Abstract Solid tumors are often characterized by a dense extracellular matrix (ECM) that contributes to increased tissue stiffness. Collagen type I is the main component of the ECM and its abundance in tumors is frequently associated with poor prognosis. In vitro studies …

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β-adrenergic signaling blockade attenuates metastasis through activation of cytotoxic CD4 T cells

Klaire Yixin Fjæstad, Astrid Zedlitz Johansen, Hannes Linder, Kevin James Baker et autres

β-adrenergic signaling has been suggested to promote tumor growth, and β-blockers are being evaluated for repurposing for cancer treatment. Here, we identify a β-adrenergic signaling axis involved in metastasis formation. We show that the β-blocker propranolol has strong anti-metastatic activity in multiple …

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Acquired resistance to immunotherapy in solid tumors

Perrine Verdys, Astrid Zedlitz Johansen, Anurag Kumar Gupta, Mario Presti et autres

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β-adrenergic signaling blockade attenuates metastasis through activation of cytotoxic CD4 T cells

Daniel Hargbøll Madsen, Klaire Yixin Fjæstad, Astrid Zedlitz Johansen, Hannes Linder et autres

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Exposition systémique et profil d’innocuité du delgocitinib en crème chez les adultes atteints d’eczéma chronique des mains modéré à sévère dans l’essai de phase 3 DELTA-2

Delphine Staumont-Sallé, Melinda Gooderham, Diamant Thaçi, Tina Damgaard et autres

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53695 Systemic exposure and safety profile of delgocitinib cream in adults with moderate to severe chronic hand eczema in the Phase 3 DELTA-2 trial

Melinda Gooderham, Diamant Thaçi, Tina Damgaard, Daniel Hargbøll Madsen et autres

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656 - Systemic exposure and safety profile of delgocitinib cream in adults with moderate to severe chronic hand eczema in the phase 3 DELTA-2 trial

Melinda Gooderham, Diamant Thaçi, Tina Damgaard, Daniel Hargbøll Madsen et autres

Abstract Introduction/Background In the DELTA-2 (NCT04872101) Phase 3 trial, delgocitinib cream 20 mg/g, a topical pan-Janus kinase inhibitor, was well-tolerated and demonstrated significant improvement in all efficacy endpoints versus cream vehicle in adults with moderate to severe chronic hand eczema (CHE). Objectives …

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Dissecting tumor microenvironment heterogeneity in syngeneic mouse models: insights on cancer-associated fibroblast phenotypes shaped by infiltrating T cells

Marco Carretta, Marie‐Louise Thorseth, Aimilia Schina, Dennis Alexander Agardy et autres

Murine syngeneic tumor models have been used extensively for cancer research for several decades and have been instrumental in driving the discovery and development of cancer immunotherapies. These tumor models are very simplistic cancer models, but recent reports have, however, indicated that …

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134 Clinical response to IL-22RA1 blockade is associated with reduction of systemic inflammation

Diamant Thaçi, Melinda Gooderham, Vivian T. Laquer, Charles W Lynde et autres

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