Nansheng Wan

A novel proliferative candidate genes panel for idiopathic pulmonary fibrosis: insights from integrated bulk and single-cell RNA sequencing

Q. Daniel Wang, Chunli Tang, Qi Wu, Nansheng Wan et autres

Abstract Background Idiopathic pulmonary fibrosis (IPF) remains a fatal interstitial lung disease with limited diagnostic specificity and therapeutic options. This study integrates bulk and single-cell RNA sequencing (RNA-seq) to identify novel biomarkers and elucidate molecular mechanisms underlying IPF pathogenesis. Methods We prospectively …

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I-125 brachytherapy for early-stage non-small cell lung cancer

Nansheng Wan, Guangsheng Li, Yubao Wang, Jing Hai Feng

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Chinese expert consensus on shape-sensing robotic-assisted bronchoscopy (ssRAB) in the management of peripheral pulmonary lesions

Fangfang Xie, Expert Group on Technology of Shape-sensing Robotic-assisted Bronchoscopy, Chunxi Zhang, Chun Guang Li et autres

Background: Shape-sensing robotic-assisted bronchoscopy (ssRAB) is a new bronchoscopy technology that utilizes optic fibers to provide accurate position information and robotic-control to deliver improved maneuverability. This technology has been used in the United States since 2019 and investigated in China since 2021. …

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Diagnostic value and safety of contact laser-assisted endobronchial ultrasound-guided tunnel drilling biopsy in mediastinal and hilar lymphadenopathy: a retrospective study

Wenyu Zhan, Tian Wang, Changqing Yang, Yubao Wang et autres

Introduction: Mediastinal and hilar lymphadenopathies are primarily diagnosed pathologically. Contact laser-assisted endobronchial ultrasound-guided tunnel drilling biopsy (EBUS-TDB), which uses a laser as a tunneling and incision tool, may yield more satisfactory specimens than conventional endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), thereby improving …

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Diagnostic Value of Endobronchial Ultrasound-Guided Intranodal Forceps Biopsies Combined with Rapid On-Site Evaluation for Mediastinal/Hilar Lymph Node Disease

Zhongli Wang, Peng Xu, Nansheng Wan, Jing Feng

Aims/Background Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the standard method for sampling mediastinal/hilar lymph node disease. However, the smaller samples obtained via needle aspiration have a lower diagnostic rate for benign compared to malignant diseases. The low diagnostic rates have been …

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Diagnostic value and safety of contact laser-assisted endotracheal ultrasound-guided tunnel drilling biopsy in mediastinal and hilar lymphadenopathy: a retrospective study

Wenyu Zhan, Tian Wang, Changqing Yang, Yubao Wang et autres

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Association of CLDN molecules with sleep apnea hypopnea syndrome: new biomarker candidates

Dan Liu, Meng Han, Nansheng Wan, Jing Feng

Introduction: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder, and has become a serious threat to public health. Intermittent hypoxia caused by OSA results in a low-grade inflammatory response that leads to impaired mucosal barrier function. Claudin (CLDN) molecules are …

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Chinese expert consensus on cone‐beam CT ‐guided diagnosis, localization and treatment for pulmonary nodules

Dongyang Xu, Fangfang Xie, Jisong Zhang, Hong Chen et autres

Cone-beam computed tomography (CBCT) system can provide real-time 3D images and fluoroscopy images of the region of interest during the operation. Some systems can even offer augmented fluoroscopy and puncture guidance. The use of CBCT for interventional pulmonary procedures has grown significantly …

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Application of rigid bronchoscopy with endoscopic bronchial ultrasound-guided transbronchial node biopsy in pulmonary sarcoidosis

Nansheng Wan, Han Meng, zhongli wang, yu shi et autres

Abstract Background Pathological examination of diseased lymph nodes is crucial for diagnosing pulmonary sarcoidosis, and obtaining quality histological specimens is important for improving the diagnosis rate. This study assessed the diagnostic rate and safety differences associated with performing endobronchial ultrasound-guided transbronchial node …

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Navigated transbronchial needle biopsy of mediastinal lymph nodes (Navi-TBNA)– a feasibility trial

Felix J.F. Herth, Konstantina Kontogianni, Li Xu, Yu Li et autres

Background: The number of Solitary pulmonary nodules are growing. In small lesions robotic and navigated procedures using virtual pathway are in use. A second procedure for the staging of the mediastinum is therefor needed. The question was, can the virtual support also …

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Bronchoscopic instillation of amphotericin B is a safe and effective measure to treat pulmonary mycosis

Lei Yang, Chang-qing Yang, Nansheng Wan, Wei Xie et autres

Background and objectives: In recent years, there has been a significant increase in the prevalence of pulmonary mycosis disease, and its mortality has increased. There are very few studies on treating pulmonary mycosiss with bronchoscopic instillation of amphotericin B. This study investigated …

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Potential biomarkers for diagnosis and disease evaluation of idiopathic pulmonary fibrosis

Qing Wang, Zhaoliang Xie, Nansheng Wan, Zhixian Jin et autres

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease characterized by progressive lung fibrogenesis and histological features of usual interstitial pneumonia. IPF has a poor prognosis and presents a spectrum of disease courses ranging from slow evolving disease to rapid …

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