Ericka Vélez-Bonet

Lack of tumor-derived LCN2 sensitizes pancreatic cancer cells to ferroptosis induction

Valentina Pita-Grisanti, Kristyn Gumpper, Claire Cornellier, Hsiang‐Yin Hsueh et autres

Lipocalin 2 (LCN2) is upregulated in many cancers, including pancreatic ductal adenocarcinoma (PDAC), and contributes to tumor development. LCN2 regulates microbial composition, which can influence PDAC outcomes, and has been implicated in ferroptosis resistance in several cancer types. However, the role of …

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Supplementary Figure 7 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Pathological distribution and disease burden indicating suppression of PDAC development by KD in obesity-associated models.

Supplementary Table 1 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Macronutrient composition and ingredient content of experimental diets, including matched low-fat controls for HFD, DIO, and KD formulations.

Supplementary Figure 8 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

KD effects in an orthotopic PDAC model, showing no inhibition of tumor growth regardless of weight loss.

Supplementary Figure 1 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Body composition (% fat and lean mass) of control and KrasG12D mice after 15 weeks on LFD or DIO diets.

Data from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor outcomes. Obesity increases the risk of PDAC through metabolic dysregulation and inflammation. Ketogenic diet (KD) can alter metabolism and has been evaluated for its effects on tumor progression in nonobese PDAC …

Supplementary Figure 5 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Representative H&E liver histology showing genotype-dependent differences between control and KrasG12D mice under varying dietary fat conditions.

Supplementary Figure 10 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Pancreatic lesion severity in KrasG12D mice selected for metabolomic analysis across diet groups.

Supplementary Figure 4 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Pancreatic β-hydroxybutyrate concentrations in KrasG12D mice across diet groups following KD intervention.

Supplementary Figure 9 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Tumor growth, body weight, glucose tolerance, and ketone levels in a non-obese orthotopic PDAC model, showing no effect of KD on tumor growth.

Supplementary Figure 3 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Severity and distribution of pancreatic lesions across diet groups after 15 weeks, prior to intervention.

Supplementary Figure 2 from Ketogenic Diet Prevents Obesity-Associated Pancreatic Cancer Independent of Weight Loss and Induces Pancreatic Metabolic Reprogramming

Ericka Vélez-Bonet, Kristyn Gumpper, Kaylin M. Chasser, Zachary A. Hurst et autres

Glucose tolerance by AUC at baseline and after 15 weeks, showing increased glucose intolerance following DIO compared to LFD.