Takashi Miida

Diagnostic performance of serum sterols, including oxysterols, for identifying cerebrotendinous xanthomatosis and monitoring treatment efficacy

Rieko Sagara, Satoshi Hirayama, Yoshifumi Fukushima, Tsuyoshi Ueno et autres

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Moving Toward Universal Risk Stratification: Globally Standardized Lipoprotein(a) in Molar Units

Takashi Miida

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BAP1 and USP1 cooperate to regulate FANCD2 stability and cell proliferation in mesothelioma cells

Koya Suzuki, Shinichi Kiyonari, Jo Nishino, Miki Takahashi et autres

BRCA1-associated protein 1 (BAP1) is frequently inactivated in pleural mesothelioma and functions as a tumor suppressor through its deubiquitinating activity. In this study, we investigated the context-dependent interplay between BAP1 and ubiquitin-specific protease 1 (USP1) in mesothelioma cells, focusing on their roles …

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Declining Seroprevalence of Strongyloidiasis in Okinawa, Japan: A Cross-Sectional Study

Akihiro Kosuge, Naoyuki Fukuda, Asano Funakoshi, Naoko Yoshida et autres

Strongyloidiasis remains endemic in Okinawa, Japan; however, epidemiological data over the past 30 years are limited. This study aimed to assess the current seroprevalence of strongyloidiasis in Okinawa. We conducted a cross-sectional study at Okinawa Chubu Hospital in 2022. Serum samples from …

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Efficacy of Skeletal Muscle Assessment Using Quantitative Ultrasonography

Yuri Ichikawa, Yoshifumi Fukushima, Kentaro Sakamaki, Satoshi Hirayama et autres

Purpose Noninvasive and repeatable ultrasonography is the possible method for the evaluation of muscle mass and development. However, there are few reports about evaluation criteria for skeletal muscle mass that consider the differences in individual physiques. Therefore, we investigated the effect of …

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Hemolysis and Iron Metabolism After Regular Exercises in Competitive Judo Athletes

Yoshifumi Fukushima, Satoshi Hirayama, Rina Nishiie-Yano, TSUYOSHI UENO et autres

Purpose Exercise-induced hemolysis has been reported to occur during intense physical exercises such as marathon. However, it is uncertain to occur during other sports with physical contact. Therefore, we performed to examine whether serum iron concentration increases after regular Judo exercise, and …

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Changes in Biochemical Parameters and Free Glycerol Levels After a Short-Term Weight- Reduction Program in Judo Athletes

Satoshi Hirayama, TSUYOSHI UENO, Takumi Kanemochi, Yuri Ichikawa et autres

Aim Appropriate weight loss via diet and exercise can protect elderly individuals from lifestyle diseases related to frailty and sarcopenia. Although weight loss by lipolysis benefits the metabolic profile, it may be difficult to evaluate metabolic changes over the short term. Therefore, …

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Harmonization of Lipoprotein(a) Immunoassays with the IFCC- Endorsed Reference Measurement Procedure Validated in Patient Samples and Multiple Routine testing as A Second Step Towards Apolipoprotein Standardization

Keita Yamashita, Mitsuru Wakita, Noriyasu Niizeki, Satomi Ito et autres

Aim: Lipoprotein(a) [Lp(a)] is an independent risk factor for cardiovascular disease (CVD); however, the goal of resolving its measurement issues remains unachieved. Expanding on the “first step” by Miida et al., this study evaluated the feasibility of harmonizing Lp(a) measurements using an …

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Species Distribution and Antifungal Susceptibility of Fungal Blood Isolates over a 16-Year Period at a University Hospital

Shigeki Misawa, Masayoshi Chonan, Gene Igawa, Maika Takahashi et autres

This study aimed to investigate the species distribution and antifungal susceptibility of fungal blood isolates collected at a university hospital between 2008 and 2023. A total of 395 fungal isolates were identified, with Candida albicans being the most prevalent species (46.1%), followed …

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Enhancement of ABCA1 and ABCG1 Expression and Cholesterol Efflux by a Metabolite of Tipelukast: A Potential Therapeutic Strategy for Atherosclerosis

Hongyan Qi, Masatsune Ogura, Kazuko Matsuda, Takashi Miida

AIMS: MN-001 (tipelukast), a compound with lipid-modulating and anti-inflammatory properties, and its active metabolite MN-002, have been suggested to influence cholesterol metabolism. This study aimed to investigate whether MN-001 and MN-002 enhance cholesterol efflux via ABCA1 and ABCG1, thereby reducing foam cell …

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Preβ1-high-density lipoprotein binds to TG-rich lipoproteins and its release is impaired in the postprandial state among patients with poorly controlled type 2 diabetes

Yuna Horiuchi, Satoshi Hirayama, Atsushi Hori, Yuri Ichikawa et autres

Background Although preβ1-high-density lipoprotein (preβ1-HDL) promotes cholesterol efflux, high fasting preβ1-high-density lipoprotein levels after breakfast are reduced in patients with poorly controlled type 2 diabetes. Objective This study investigated whether preβ1-high-density lipoprotein binds to triglyceride (TG)-rich lipoproteins (TGRLs) in the postprandial state …

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Identification of Elizabethkingia species by MALDI-TOF MS proteotyping

Satomi Takei, Kanae Teramoto, Yuji Sekiguchi, Takashi Miida et autres

ABSTRACT Elizabethkingia species, isolated from clinical and environmental samples, are emerging opportunistic bacterial pathogens with a high mortality rate in clinical settings worldwide. Taxonomically, Elizabethkingia comprises seven species: E. anophelis , E. argenteiflava , E. bruuniana , E. meningoseptica , E. miricola …

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