Evgeni Mekov

Synchronous Primary Atypical Pulmonary Carcinoid and Cecal Adenocarcinoma: A Case Report

G. Gergov, Magdalena Alexieva, Evgeni Mekov, Nikolay Yanev et autres

Abstract Pulmonary carcinoid tumors are a rare subgroup of neuroendocrine lung neo-plasms, accounting for approximately 1-2% of all primary lung cancers. The occurrence of synchronous primary malignancies involving pulmonary carcinoid and colorectal adeno-carcinoma is exceptionally uncommon. We report a 78-year-old woman initially …

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From planning to savings: CRC screening organization and cost-utility analysis of early CRC detection in Bulgaria

H. Krastev, Evgeni Mekov, Veneta Todorova, Georgi Slavchev et autres

BACKGROUND: Colorectal cancer (CRC) is the most commonly diagnosed cancer in Bulgaria and the second leading cause of cancer-related death. Bulgaria has increased CRC mortality, highlighting the urgent need for effective screening interventions. This study evaluated the operational outcomes and cost-utility of …

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Combined Extra- and Intrathoracic (Dumbbell) Lipoma Crossing the Third Intercostal Space

Magdalena Alexieva, Georgi Gergov, Evgeni Mekov, Elitsa Yankova et autres

Intrathoracic lipomas are uncommon, and dumbbell (hourglass) lesions with contiguous extra- and intrathoracic components are exceedingly rare. Surgery is indicated for enlarging or symptomatic tumors or when imaging raises concern for malignancy (e.g., infiltration). Complete resection - via thoracotomy or video-assisted thoracoscopic …

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Giant Retroperitoneal Schwannoma: Case Report and Review of the Literature

Magdalena Alexieva, Evgeni Mekov, Silvia Ivanova, A. Vlahova et autres

Retroperitoneal schwannomas are rare benign tumors of peripheral nerve sheath origin. We report a 72-year-old woman presenting with abdominal pain, altered bowel habits, and intermittent fever. CT imaging revealed a large (83 × 83 × 104 mm), well-circumscribed retroperitoneal mass with calcifications …

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Sternal Tumor Resection and Complex Chest Wall Reconstruction of a Solitary Plasmacytoma: A Report of a Rare Case

Magdalena Alexieva, Georgi Gergov, Evgeni Mekov, Silvia Ivanova et autres

Localized sternal plasmacytoma is a rare and aggressive oncologic condition. Surgical resection followed by radiotherapy offers the highest chance of cure. Radical resection of the chest wall is technically feasible and is associated with improved outcomes. Subsequent reconstruction using meshes, plates, and …

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Open surgery after failed laparoscopy for hiatal hernia and open transthoracic Collis procedure in acquired shortened esophagus

Georgi Yankov, Magdalena Alexieva, Borislav Vladimirov, Evgeni Mekov

Hiatal hernia is defined as the movement of internal organs and more commonly the stomach from the abdominal cavity to the mediastinum. Laparoscopic techniques introduced in the early 1990s have completely changed the approach to the treatment of hiatal hernias, and they …

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Long-term follow-up of cystic fibrosis patients in the Pleven region over a 28-year period

N. Kolarova, Evgeni Mekov, Nikolay Yanev, V. Nedkova

Introduction: Cystic fibrosis is a multi-organ genetic disorder with over 1,300 known mutations in the CFTR gene. The diversity of genetic variations leads to a wide range of clinical manifestations and disease severity. Aim: A retrospective analysis of genetic variants, their associated …

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A Rectus Abdominis Muscle Flap for Chest Wall Resection and Reconstruction for Malignant Breast Cancer Relapse

Georgi Yankov, Magdalena Alexieva, Zaharinka Makshutova, Evgeni Mekov

Abstract Reconstruction of postoperative chest wall defects with a rectus abdominis muscle flap is a relatively rare technique. We present a case of a 78-year-old woman who was operated 11 years ago for solid papillary carcinoma of the left mammary gland with …

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Phenotyping Chronic Obstructive Pulmonary Disease Through Principal Component Analysis: Identification of Clinical Clusters

Evgeni Mekov, Nikolay Yanev, Nedelina Kurtelova, Teodora Mihalova et autres

Introduction Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition with varied clinical presentations and prognoses. Identifying patient phenotypes is essential for developing personalized treatment strategies. Principal component analysis (PCA) is a statistical method that can be employed to uncover clinical clusters …

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Prevalence and Prognostic Value of Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease

Evgeni Mekov, Nikolay Yanev, Nedelina Kurtelova, Teodora Mihalova et autres

Introduction Pulmonary hypertension (PH) significantly influences chronic obstructive pulmonary disease (COPD) outcomes by exacerbating symptoms, increasing the frequency and severity of exacerbations, and contributing to higher hospitalization rates and mortality. Ultrasound assessment of mean pulmonary arterial pressure (PAPm) may contribute to the …

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Clinical and laboratory characteristics of patients with IgA nephropathy and related diseases: analysis of 49 cases

Stefka Yankova, Georgi Yankov, Evgeni Mekov, Galya ZLATANOVA

BACKGROUND: IgA nephropathy (IgAN) is the most common primary chronic glomerulopathy worldwide. The clinical presentation and progression of the disease range widely from asymptomatic hematuria to rapidly progressive glomerulonephritis or development of terminal renal failure.METHODS: A retrospective analysis of 49 children with …

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4 The Impact of Smoking Status and COPD Severity on Lung Cancer Metastasis: A Retrospective Study

Mihalova Teodora, Evgeni Mekov

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