Kent A. Willis

Opening the black box: reflections from the AJP-Lung early career editorial fellows

Stefan Hadžić, Simon J. Cleary, Daniel Colon Hidalgo, Jana Grune et autres

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The evolving pathophysiology of bronchopulmonary dysplasia

Namasivayam Ambalavanan, Gail Deutsch, Gloria Pryhuber, Colm P. Travers et autres

Bronchopulmonary dysplasia (BPD) is the most common morbidity in very preterm infants and is characterized by abnormal development of the lung. The pathophysiology of BPD is primarily due to the effects of placental dysfunction, hyperoxia, ventilator-induced lung injury, poor nutrition, abnormal blood …

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MicroRNA Let-7b-5p is a Biomarker and Potential Therapeutic Target in Bronchopulmonary Dysplasia

Namasivayam Ambalavanan, N. Olave, Kent A. Willis, Jegen Kandasamy et autres

Abstract RATIONALE: In STOP BPD (Signature of Top Omic Profiles of BPD; R01HL129907) project, we identified clinical and “omic” biomarkers associated with risk of BPD in a prospective cohort of 302 extremely preterm infants. The “omic” biomarkers included transcriptomic (mRNA and miRNA; …

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Early Multiomic Signals of Severe Bronchopulmonary Dysplasia in Extremely Low Birthweight Premature Infants

Kent A. Willis, Nelida Olave, Isaac Martin, Ammar Majeed et autres

Abstract Background: Biomarker-based estimation of the risk of developing severe bronchopulmonary dysplasia (SevBPD) near birth may facilitate personalized therapy in extremely low birthweight (ELBW) newborns. Methods: We collected blood samples within 72 hours of birth in a prospective observational cohort of 302 …

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Senescence at the Crossroads of Lung Development and Injury

Kent A. Willis, Namasivayam Ambalavanan

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The fungal microbiota modulate neonatal oxygen-induced lung injury

Isaac Martin, Mary Silverberg, Ahmed Abdelgawad, Kosuke Tanaka et autres

BACKGROUND: The immature lungs of very preterm infants are exposed to supraphysiologic oxygen, contributing to bronchopulmonary dysplasia (BPD), a chronic lung disease that is the most common morbidity of prematurity. While the microbiota significantly influences neonatal health, the relationship between the intestinal …

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A lactobacilli-based inhaled live biotherapeutic product attenuates pulmonary neutrophilic inflammation

Teodora Nicola, Nancy M. Wenger, Xin Xu, Michael Evans et autres

Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity. Exposure to noxious stimuli such as hyperoxia, volutrauma, and infection in infancy can have long-reaching impacts on lung health and predispose towards the development of conditions such as chronic obstructive pulmonary disease …

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The IL-33/ST2-axis Contributes to the Development of Bronchopulmonary Dysplasia-associated Pulmonary Hypertension

Kent A. Willis, Kosuke Tanaka, Isaac Martin, Ahmed Abdelgawad et autres

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Mediators of Antenatal Inflammation Propagating Chronic Neonatal Lung Disease

Viral G. Jain, Ihab Abdelgawwad, Alexa Brooks, Kent A. Willis et autres

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934 Long-term childhood outcomes after pregnancy complicated by isolated polyhydramnios

Michael M. Aziz, Tyson S. Barrett, Ahizechukwu C. Eke, Kent A. Willis

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Antimicrobial peptides modulate lung injury by altering the intestinal microbiota

Ahmed Abdelgawad, Teodora Nicola, Isaac Martin, Brian Halloran et autres

BACKGROUND: Mammalian mucosal barriers secrete antimicrobial peptides (AMPs) as critical, host-derived regulators of the microbiota. However, mechanisms that support microbiota homeostasis in response to inflammatory stimuli, such as supraphysiologic oxygen, remain unclear. RESULTS: We show that supraphysiologic oxygen exposure to neonatal mice, …

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Altered hepatic and intestinal homeostasis in a neonatal murine model of short-term total parenteral nutrition and antibiotics

Tahliyah S. Mims, Roshan Kumari, Cameron Leathem, Karen Antunes et autres

This study successfully established a translationally relevant, murine neonatal parenteral nutrition (PN) model. Short-term PN is sufficient to induce hepatitis-associated cholestasis in a neonatal murine model that can be used to understand disease in early life. The administration of antibiotics during PN …

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