Juliette Degens

Development of a rapid ex vivo tumor platform for drug response prediction in lung cancer

Rianne D.W. Vaes, Zhongli Chen, Iris E. W. G. Laven, Shaowen Lyu et autres

Despite advances in systemic therapies for patients with (locally) advanced stage lung cancer, response rates remain poor, underscoring the urgent need for predictive models to guide therapy selection. Patient-derived ex vivo models are promising, however, their clinical utility is restricted by the …

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124P Assessing the prognostic value of clinical and radiomics features in synchronous oligometastatic NSCLC

Mandy Jongbloed, Valentina Bartolomeo, H. Gietema, Jarno W J Huijs et autres

Current guidelines recommend adding local radical treatment (LRT) to systemic therapy in patients (pts) with synchronous oligometastatic (sOM) non-small cell lung cancer (NSCLC). While some achieve long-term survival, many pts experience early progression (PD), stressing the need for biomarkers to identify who …

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A Network Meta-Analysis of Drainage Systems and Suction Strategies After Lung Cancer Surgery

Lars Geenen, Koen C H A Verkoulen, Iris E W G Laven, Jean H. T. Daemen et autres

OBJECTIVES: Optimizing chest drainage management after lung cancer surgery plays a pivotal role in minimizing drainage time and shortening length of hospital stay (LOHS). Currently, a universally acceptable standard is lacking, and a wide range of drain management strategies are practiced. Therefore, …

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Rethinking preventing postoperative neurocognitive decline after pulmonary resection: beyond avoiding intubated general anesthesia

Gaston H. N. M. Duijsens, Aimée J P M Franssen, Pauline van Kruchten, Walther M. W. H. Sipers et autres

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Effect of treatment sequencing on outcome of patients with non-small cell lung cancer with a synchronous solitary extrathoracic metastasis

Mandy Jongbloed, Ronald AM Damhuis, Wouter H. van Geffen, Peter de Boer et autres

Currently, guidelines advise local radical treatment (LRT) to all disease sites in addition to systemic therapy in patients with synchronous oligometastatic non-small cell lung cancer (NSCLC). However, the best order of treatments is unknown. This advice is largely based on expert opinion …

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Overall survival in patients with non-small cell lung cancer and leptomeningeal metastases: Data from the Dutch cancer Registry

Jarno W J Huijs, Francesca Rita Ogliari, Ronald Damhuis, Mandy Jongbloed et autres

BACKGROUND: Leptomeningeal metastases (LM) at initial diagnosis are a rare manifestation in patients with non-small cell lung cancer (NSCLC), historically associated with poor survival and limited treatment options. With the introduction of immune checkpoint inhibitors (ICIs) and next-generation targeted therapies, treatment opportunities …

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Association of metabolic tumour volume (MTV) and total lesion glycolysis (TLG) with survival in patients with oligometastatic non-small-cell lung cancer treated with immunotherapy: a multicentre retrospective study

Francesca Rita Ogliari, Mandy Jongbloed, Rianne D.W. Vaes, Ruud Houben et autres

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Clinical risk factors for developing brain metastases during first-line (chemo-)immunotherapy in patients with non-small cell lung cancer without known baseline brain metastases

Jarno W J Huijs, Anna Sadowska, Juliette Degens, C. Steendam et autres

BACKGROUND: Brain metastases (BM) are common in non-small cell lung cancer (NSCLC). Although guidelines recommend baseline BM screening in asymptomatic patients, its benefit remains unproven. Routine imaging burdens healthcare systems and patients. Immune checkpoint inhibitors (ICI) show similar intra-and extracranial response percentages, …

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Advancements in 3D lung models for minimally invasive lung cancer surgery: from static to real-time dynamic modeling

Iris E W G Laven, Aimée J P M Franssen, Lori M. van Roozendaal, Juliette Degens et autres

Three-dimensional (3D) lung models have become a valuable tool in surgical planning and intraoperative navigation by providing detailed visualizations of pulmonary structures (e.g., bronchial tree, pulmonary vasculature, lung parenchyma, and tumor). These models are useful in minimally invasive lung cancer surgery, particularly …

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The evolution of chest tube management following lung cancer surgery: many options, scarce evidence

Lars Geenen, Koen C H A Verkoulen, Aimée J P M Franssen, Juliette Degens et autres

After lung cancer surgery, a chest tube is routinely placed to prevent complications such as a pneumothorax or pleural effusion. However, chest tube placement often comes with patient discomfort, impaired mobilization, and prolonged hospitalization, necessitating improved chest drain policies to reduce drainage …

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Beyond the tumor: towards a cachexia-based host phenotype through body composition analysis in patients with resectable lung cancer

Koen C H A Verkoulen, Lars Geenen, Aimée J P M Franssen, Annemarie Verzijl et autres

Cancer cachexia, characterized by involuntary weight loss and extensive muscle and adipose tissue wasting, is a major contributor to morbidity and mortality in cancer patients. To date, no effective medical intervention can completely reverse this multifactorial syndrome, which is driven by different …

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Isolated nodal failure in stage III non-small-cell lung cancer after proton therapy with or without durvalumab

Kyra van Keeken, Judith van Loon, Stéphanie Peeters, Bart Reymen et autres

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