Mark N. Levine

Stereotactic Versus Conventional Radiotherapy in Medically Inoperable Stage I Non–Small Cell Lung Cancer: A Bayesian Reanalysis of the LUSTRE Randomized Trial

Yanchen Wang, E. Donovan, Mark N. Levine, Timothy J. Whelan et autres

Introduction : The results of the LUSTRE trial investigating stereotactic body radiotherapy in early-stage non-small cell lung cancer were inconclusive. A Bayesian analysis could potentially address this by integrating prior knowledge. Methods : The LUSTRE trial was a randomized-controlled superiority trial conducted …

ca (code pays fourni par la source)

Prospective study on 18F-FDG PET-CT for staging locally advanced invasive lobular breast carcinoma

Ur Metser, Ian S. Dayes, Sameer Parpia, Andrea Eisen et autres

ca (code pays fourni par la source)

CYTOSHRINK: A randomized phase II trial of cytoreductive stereotactic hypofractionated radiotherapy with ipilimumab/nivolumab for metastatic kidney cancer.

Aly‐Khan A. Lalani, Gregory Russell Pond, Shankar Siva, William Chu et autres

416 Background: Patients (pts) presenting with de novo metastatic renal cell carcinoma (mRCC) have a poor prognosis. The role of cytoreductive nephrectomy (CN) is uncertain in these pts. Stereotactic body radiation therapy (SBRT) provides a convenient method for cytoreduction of the primary …

ca, au (code pays fourni par la source)

Quality of Life of Stereotactic Versus Hypofractionated Radiation Therapy for Inoperable Stage I Non-Small Cell Lung Cancer: Results From the LUSTRE Trial

Qiao Ling Hou, Sameer Parpia, Marcin Wierzbicki, Vijayananda Kundapur et autres

PURPOSE: There is limited evidence on quality-of-life (QoL) outcomes of stereotactic body radiation therapy (SBRT) compared with conventionally hypofractionated radiation therapy (CHRT) in patients with medically inoperable stage I (≤5 cm) non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: This phase 3 …

ca (code pays fourni par la source)

Participation in U.S.‐Based ALS Clinical Trials by Sex and Race

Mark N. Levine, Sun Young Chung, Kellen H. Quigg, Judith Carey et autres

INTRODUCTION/AIMS: In global amyotrophic lateral sclerosis (ALS) trials, women and men appear to be proportionately enrolled, but quantification of enrollment by sex and race in U.S.-based ALS trials is limited. The objective of this study was to evaluate the sex and race …

us (code pays fourni par la source)

18F-FDG PET/CT of Oligometastatic Disease in Locally Advanced Breast Cancer: PETABC Trial Post Hoc Analysis

Ur Metser, Seyed Ali Mirshahvalad, Ian S. Dayes, Sameer Parpia et autres

At initial staging of locally advanced invasive ductal carcinoma, fluorine 18 fluorodeoxyglucose PET/CT helped to identify oligometastatic disease in 10% of patients and supraclavicular and/or internal mammary lymph node metastases in approximately one-third of patients.

ca (code pays fourni par la source)

Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy

Jeremy Braybrooke, Rosie Bradley, Robert K. Hills, R Peto et autres

BACKGROUND: In postmenopausal women with oestrogen receptor-positive early breast cancer, 5 years of adjuvant tamoxifen substantially reduces 15-year recurrence and mortality; aromatase inhibitor treatment (AIT) is even more effective. We assess the effects of further AIT among women recurrence-free after at least …

Radiation omission in patients with clinically node-negative breast cancer undergoing lumpectomy (ROSALIE).

Elena Parvez, Mark Basik, Sameer Parpia, Mark N. Levine et autres

TPS628 Background: Currently, the standard of care for patients undergoing neoadjuvant chemotherapy (NAC) and breast conserving surgery (BCS) is adjuvant radiation (RT). However, high rates of pathologic complete response (pCR) after NAC have raised questions regarding the necessity of WBRT in these …

ca (code pays fourni par la source)

β-actin function in platelets and red blood cells can be performed by γ-actin and is therefore independent of actin isoform protein sequence

Devasmita Chakravarty, Pavan Vedula, Megan Coffin, Li Chen et autres

Actin is an essential component of the cytoskeleton in every eukaryotic cell. β-and γ-nonmuscle actin are over 99% identical to each other at the protein level but are encoded by different genes and play distinct roles in vivo. Blood cells, especially red …

us (code pays fourni par la source)

Altered RBC deformability in diabetes: clinical characteristics and RBC pathophysiology

Ifechukwude Ebenuwa, Pierre-Christian Violet, Hongbin Tu, Casey Lee et autres

BACKGROUND: Reduced red blood cell deformability (RBCD) is associated with diabetic vascular complications, but early pathophysiological RBC changes and predictive demographic and clinical factors in populations with diabetes are unclear. An understanding of early diabetes-specific RBC changes associated with impaired RBCD is …

us (code pays fourni par la source)

OPAR: A Randomized Trial of Partial Breast Irradiation in Five Fractions Once Daily for Early Breast Cancer

Do‐Hoon Kim, Valérie Théberge, Sameer Parpia, Iwa Kong et autres

PURPOSE: Previous studies suggest that external-beam partial breast irradiation (PBI) delivered twice a day can lead to increased adverse cosmesis (AC). The objective of our trial was to determine whether two regimens for PBI given once daily over 1 week resulted in …

ca (code pays fourni par la source)

Stereotactic vs Hypofractionated Radiotherapy for Inoperable Stage I Non–Small Cell Lung Cancer

Anand Swaminath, Sameer Parpia, Marcin Wierzbicki, Vijayananda Kundapur et autres

Importance Stereotactic body radiotherapy (SBRT) is widely used for stage I medically inoperable non–small cell lung cancer (NSCLC), yet varied results from randomized clinical trials (RCTs) and concerns in treating centrally located tumors persist. Objective To examine whether SBRT would improve local …

ca (code pays fourni par la source)