Maddalena D. Caiati

Rapid synaptic and gamma rhythm signature of mouse critical period plasticity

Kathleen B. Quast, Rebecca K. Reh, Maddalena D. Caiati, Nancy Kopell et autres

Early-life experience enduringly sculpts thalamocortical (TC) axons and sensory processing. Here, we identify the very first synaptic targets that initiate critical period plasticity, heralded by altered cortical oscillations. Monocular deprivation (MD) acutely induced a transient (<3 h) peak in EEG γ-power (~40 …

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Emerging Mechanisms Underlying Dynamics of GABAergic Synapses

Arianna Maffei, Cécile Charrier, Maddalena D. Caiati, Andrea Barberis et autres

Inhibitory circuits are diverse, yet with a poorly understood cell biology. Functional characterization of distinct inhibitory neuron subtypes has not been sufficient to explain how GABAergic neurotransmission sculpts principal cell activity in a relevant fashion. Our Mini-Symposium brings together several emerging mechanisms …

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PrPCControls via Protein Kinase A the Direction of Synaptic Plasticity in the Immature Hippocampus

Maddalena D. Caiati, Victoria F. Safiulina, Giorgia Fattorini, Sudhir Sivakumaran et autres

The cellular form of prion protein PrP(C) is highly expressed in the brain, where it can be converted into its abnormally folded isoform PrP(Sc) to cause neurodegenerative diseases. Its predominant synaptic localization suggests a crucial role in synaptic signaling. Interestingly, PrP(C) is …

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Is GABA Co-Released with Glutamate from Hippocampal Mossy Fiber Terminals?

Maddalena D. Caiati

The coexistence and co-release of different neurotransmitters from the same fiber has been well documented in several brain structures, including the retina, the spinal cord, and the auditory system ([Hnasko and Edwards, 2012][1]). Although mossy fibers (MFs), the axons of dentate gyrus …

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Fluoxetine impairs GABAergic signaling in hippocampal slices from neonatal rats

Maddalena D. Caiati, Enrico Cherubini

Fluoxetine (Prozac), an antidepressant known to selectively inhibit serotonin reuptake, is widely used to treat mood disorders in women suffering from depression during pregnancy and postpartum period. Several lines of evidence suggest that this drug, which crosses the human placenta and is …

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Activity-dependent regulation of GABA release at immature mossy fibers-CA3 synapses: role of the Prion protein

Maddalena D. Caiati

Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses

Maddalena D. Caiati, Sudhir Sivakumaran, Frédéric Lanore, Christophe Mulle et autres

Early in postnatal life, mossy fibres (MF), the axons of granule cells in the dentate gyrus, release GABA which is depolarizing and excitatory. Synaptic currents undergo spike-time dependent long-term depression (STD-LTD) regardless of the temporal order of stimulation (pre versus post and …

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Depolarizing Actions of GABA in Immature Neurons Depend Neither on Ketone Bodies Nor on Pyruvate

Roman Tyzio, Camille Allène, Romain Nardou, Michel A. Picardo et autres

GABA depolarizes immature neurons because of a high [Cl(-)](i) and orchestrates giant depolarizing potential (GDP) generation. Zilberter and coworkers (Rheims et al., 2009; Holmgren et al., 2010) showed recently that the ketone body metabolite DL-3-hydroxybutyrate (DL-BHB) (4 mM), lactate (4 mM), or …

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In the Developing Hippocampus Kainate Receptors Control the Release of GABA from Mossy Fiber Terminals via a Metabotropic Type of Action

Enrico Cherubini, Maddalena D. Caiati, Sudhir Sivakumaran

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In the Developing Rat Hippocampus, Endogenous Activation of Presynaptic Kainate Receptors Reduces GABA Release from Mossy Fiber Terminals

Maddalena D. Caiati, Sudhir Sivakumaran, Enrico Cherubini

Presynaptic kainate receptors regulate synaptic transmission in several brain areas but are not known to have this action at immature mossy fiber (MF) terminals, which during the first week of postnatal life release GABA, which exerts into targeted cells a depolarizing and …

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The effects of mammalian prolactin and growth hormone on goldfish (Carassius auratus) growth, plasma amino acid levels and liver amino acid uptake

M M Prack, Martine Antoine, Maddalena D. Caiati, M Roskowski et autres

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