Accès ouvert
2026
article
OpenAlex
Maria E. Cabanillas, Naifa L. Busaidy, Mark Zafereo, Padmini Iyer et autres
BACKGROUND: Dabrafenib (BRAF inhibitor) plus trametinib (MEK inhibitor) is approved for BRAF V600E-mutated anaplastic thyroid cancer (ATC), but ∼60% of tumors do not harbor BRAF V600E, leaving these patients without effective treatment options. METHODS: This was a phase 2 study of patients …
us
(code pays fourni par la source)
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
Distribution of PRECISE scores based on TERT promoter mutation status in the (A) MDACC, (B) VUMC, and (C) TCGA cohorts. Abbreviations: WT, wild-type; MUT, mutated.
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
Receiver operating characteristic (ROC) curves for 177 genes cited in at least 3 publications related to aggressive PTC and 328 genes from KEGG cancer pathways.
Accès ouvert
2026
other
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
AbstractPurpose: Papillary thyroid carcinoma (PTC) exhibits heterogeneous behavior, underscoring the need for effective biomarkers and improved risk stratification methods. We developed a thyrocyte-derived gene signature, Prognostic RNA Expression Cell-specific Integrated Signature (PRECISE), using single-cell RNA sequencing (scRNA-seq) and single-nucleus RNA sequencing (snRNA-seq) …
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
Reverse Kaplan-Meier curves for (A) progression-free and (B) disease-specific survival, illustrating censoring patterns across cohorts.
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
Supplemental Table 1. Single-nucleus RNA sequencing sample information Supplemental Table 2. Canonical gene markers for cell type annotation Supplemental Table 3. PRECISE genes and their direct interactors Supplemental Table 4. List of all the genes from bulk RNA sequencing used for ranking …
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
Kaplan-Meier analysis of low- vs high-risk PRECISE score in (A-C) progression-free survival and (D-F) disease-specific survival in the MDACC, VUMC, and TCGA cohorts, respectively.
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
Network of PRECISE genes (red nodes) and their direct interactors (blue).
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
Distribution of PRECISE score in the FNA samples based on T stage.
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
Distribution of PRECISE score in the MDACC (A), VUMC (B), and TCGA (C) cohorts.
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
PCA analysis of the pseudobulk data for the PTC and normal samples.
Accès ouvert
2026
supplementary-materials
OpenAlex
Sophie H. Li, Chia-Chin Wu, Vicente Rodrigues Marczyk, Matthew A. Loberg et autres
UMAP visualization of the single-nucleus RNA sequencing data annotated by sample (A) and risk group (B) following Harmony-based batch correction; UMAP visualization of the single-nucleus RNA sequencing data for the tumor cells and normal thyroid follicular cells annotated by sample and risk …