Kei Kozawa

Safety of Rotavirus Vaccination in a Growing Care Unit (Intermediate-care Neonatal Unit) in Japan

Hiroki Miura, Masahiko Manabe, Masaru Ihira, Kei Kozawa et autres

BACKGROUND: Rotavirus vaccination effectively prevents severe rotavirus gastroenteritis; however, administration during neonatal hospitalization is often avoided because of theoretical concerns regarding vaccine-virus transmission. Data on the safety of in-hospital rotavirus vaccination in neonatal step-down care settings remain limited. METHODS: We conducted a …

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Epidemiology and Clinical Features of Epstein‐Barr Virus and Cytomegalovirus Infections in Japanese Infants and Young Children

Yotaro Kondo, Yuki Higashimoto, Fumihiko Hattori, Yoshiki Kawamura et autres

The recent clinical features of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections in young children in developed countries remain unclear. This study investigated the clinical features of EBV and CMV infections and the latest seroepidemiology in Japan. Seroprevalence was analyzed 303 stored …

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Brain Abscess Caused by Streptococcus intermedius and Aggregatibacter aphrophilus Secondary to Exfoliation of a Deciduous Tooth in a Previously Healthy Child: A Case Report

Hiroki Miura, Kei Kozawa, Jun Muto, Tetsushi Yoshikawa

This report describes the case of a previously healthy nine-year-old girl who developed a left temporal lobe brain abscess following spontaneous exfoliation of a healthy deciduous tooth. She presented in convulsive status epilepticus without fever or focal neurological symptoms, and the initial …

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Increase in Adult Patients with Varicella Zoster Virus–Related Central Nervous System Infections, Japan

Ayami Yoshikane, Hiroki Miura, Sayuri Shima, Masaaki Matsunaga et autres

An increase in the number of herpes zoster patients has been reported since universal varicella immunization was introduced, perhaps because of reduced opportunities for varicella patients to experience the natural booster effect caused by reexposure. We investigated recent trends of varicella zoster …

Temporal patterns of asymptomatic SARS‐CoV‐2 infection among pediatric population in Japan: A 3‐year analysis

Kei Kozawa, Yuki Higashimoto, Yoshiki Kawamura, Hiroki Miura et autres

To elucidate the seroprevalence and rate of asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Japanese children, serological analysis was performed using serum samples collected from March 2020 to February 2023. A total of 1493 serum samples were collected …

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Clinical Practice Guidelines for the Management of Congenital Cytomegalovirus Infection in Japan 2023: Executive Summary

Yoshinori Ito, Ichiro Morioka, Naoto Takahashi, Kazumichi Fujioka et autres

Congenital cytomegalovirus (cCMV) infection is the most common congenital infection in developed countries. Although a standard therapy has not yet been established, evidence for the management of cCMV infection has been accumulating. The first edition of the "Clinical Practice Guidelines for the …

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Assessment of patients’ characteristics associated with the efficacy and safety of oral valganciclovir treatment for infants with symptomatic congenital cytomegalovirus disease

Yasumasa Kakei, Ichiro Morioka, Takumi Imai, Kotaro Itohara et autres

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Analysis of Cytokine Profiles in Pediatric Myocarditis Multicenter Study

Yoji Nomura, Takanori Suzuki, Katsuyuki Kunida, Hidetoshi Uchida et autres

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A Girl With Adenovirus Type 2 Induced Interstitial Pneumonitis Acutely Exacerbated With Primary Human Herpesvirus 7 Infection

Yoshiki Kawamura, Kei Kozawa, Goro Koinuma, Tetsuo Onda et autres

We encountered a previously healthy 3-year-old girl with interstitial pneumonitis that initially developed due to human adenovirus type 2 infection and exacerbated by primary human herpesvirus 7 infection. A comprehensive serum biomarker analysis showed patterns that differed by viral infection, suggesting that …

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Analysis of cytokine profiles in pediatric fulminant myocarditis and acute myocarditis multicenter study

Yoji Nomura, Takanori Suzuki, Katsuyuki Kunida, Hidetoshi Uchida et autres

Abstract Introduction: Acute myocarditis (AM) is an inflammatory disease of the heart muscle that can progress to fulminant myocarditis (FM), a severe and life-threatening condition. The cytokine profile of myocarditis in children, especially in relation to fulminant myocarditis, is not well understood. …

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Serological analysis of severe acute respiratory syndrome coronavirus 2 infection in children with Kawasaki disease

Yotaro Kondo, Yoshiki Kawamura, Fumihiko Hattori, Hidetaka Nakai et autres

Multisystem inflammatory syndrome in children (MIS-C) was reported as a severe complication of coronavirus disease 2019; an infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and was suggested to be associated with Kawasaki disease (KD) in terms of severe systemic inflammation …

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Similarities in rotavirus vaccine viral shedding and immune responses in pairs of twins.

Yasuko Enya, Hiroyuki Hiramatsu, Masaru Ihira, Ryota Suzuki et autres

Objectives: (RV1) and IgG and IgA responses to RV show similarity in pairs of twins. Methods: Quantitative reverse transcription polymerase chain reaction specific to RV vaccine strain RV1 was used to monitor fecal RV1 viral shedding. RV IgG and IgA titers were …

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