Chris E. Holmes

Identifying barriers and facilitators to timely venous thromboembolism prevention in newly diagnosed pancreatic cancer: a qualitative study

Karlyn A. Martin, Ryan Thomas, Sean Britton, Chris E. Holmes et autres

This is a PDF of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability.This version will undergo additional copyediting, typesetting and review before it is published in its final …

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Development and validation of a risk assessment model for hospital-acquired venous thrombosis in medical in-patients with cancer

Karlyn A. Martin, Katherine S. Wilkinson, Andrew Dunn Sparks, Nicholas S. Roetker et autres

BACKGROUND: Existing risk assessment models (RAM) for hospital-acquired venous thromboembolism (VTE) have not been widely assessed in people with cancer or have underperformed. OBJECTIVES: We aimed to develop and validate a RAM for hospital-acquired VTE for patients with active cancer admitted to …

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Massive aortic thrombus in a hypercoagulable patient with heparin induced thrombocytopenia: a case report

Jennifer M. Messina, Napat Pruekprasert, Jason Gilbert, Mohan Sarabu et autres

Large ascending aortic thrombus can lead to devastating consequences and requires astute recognition and evaluation, systemic anticoagulation, and urgent surgical intervention. Perioperative and surgical management of a large ascending aortic thrombus is further complicated in patients who develop heparin induced thrombocytopenia (HIT) …

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Platelet FcɣRIIa: a novel biomarker of risk for thromboembolism and death in cancer

Chris E. Holmes, George A. Davis, Heidi S. Taatjes‐Sommer, Naomi E. Sai-Hardebeck et autres

Cancer is associated with arterial and venous thrombotic events (ATE/VTE). Platelet FcγRIIa (pFCG) impacts platelet activation that contributes to ATE/VTE. Recurrent myocardial infarction (MI) and death are predicted by pFCG in patients with MI. Crosstalk between platelets and malignant cells that may …

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Impact of Venous Thrombosis Prevention in Ambulatory Oncology: Importance of Guideline Adherence

Chris E. Holmes, Karlyn A. Martin, Derek Devine, Jacob Barker et autres

PURPOSE: Despite strong evidence and guidelines supporting prophylactic anticoagulation for ambulatory patients with cancer starting systemic cancer-directed therapy who are at high risk of venous thromboembolism (VTE), uptake in practice is limited. We evaluated the real-world impact of prophylactic anticoagulation in such …

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Venous thromboembolism prevention in ambulatory oncology: A multi-method evaluation of the Vermont Model to inform adaptation to an oncology-delivered model

Karlyn A. Martin, Emily Hallgren, Chris E. Holmes, Jacob Barker et autres

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Development and validation of risk models for hospital-acquired bleeding in medical inpatients: the Medical Inpatients Thrombosis and Hemostasis (MITH) study

Neil A. Zakai, Katherine S. Wilkinson, Andrew Dunn Sparks, Nicholas S. Roetker et autres

BACKGROUND: Hospital-acquired (HA) bleeding in medical inpatients is a serious complication with limited tools to predict risk. OBJECTIVES: This study aimed to develop and validate risk assessment models (RAMs) for anatomic location-specific HA bleeding in medical inpatients using objective and routinely available …

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Acute myocardial infarction in patients with cancer: outcomes and P2Y12 inhibition

Andres Cordova Sanchez, Chris E. Holmes, Harold L. Dauerman, Tanush Gupta

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Anticoagulation and other risk factors for clinically relevant bleeding after medical hospitalization: the Medical Inpatient Thrombosis and Hemostasis Study

Mansour Gergi, Katherine S. Wilkinson, Andrew Dunn Sparks, Nicholas S. Roetker et autres

BACKGROUND: Clinically relevant bleeding after discharge from a medical hospitalization is associated with increased morbidity and mortality. There is limited knowledge of the risk factors for this bleeding. OBJECTIVES: We aimed to determine the risk factors for bleeding leading to rehospitalization after …

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Risk Factors for Bleeding after Recent Medical Hospitalization: The Medical Inpatient Thrombosis and Hemostasis Study (MITH)

Mansour Gergi, Katherine S. Wilkinson, Andrew Dunn Sparks, Nicholas S. Roetker et autres

Introduction:Bleeding after discharge from a medical hospitalization is associated with increased morbidity and mortality. There is limited knowledge of the incidence of and risk factors for post-discharge bleeding Objective:To determine the incidence, timing and risk factors for bleeding leading to rehospitalization after …

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TCT-991 Ticagrelor Versus Clopidogrel in Cancer Patients With Acute Myocardial Infarction

Andres Cordova Sanchez, Chris E. Holmes, Harold L. Dauerman, Tanush Gupta

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Venous thromboembolism in patients with pancreatic adenocarcinoma: Disease burden and initiation of ambulatory thromboprophylaxis

Jason D. Heffley, Eric K. Ganguly, Bradley J. Tompkins, Steven Ades et autres

BACKGROUND/OBJECTIVES: Ambulatory thromboprophylaxis (AT) in patients with pancreatic adenocarcinoma (PAC) reduces venous thromboembolism (VTE) risk and is recommended for patients receiving systemic chemotherapy. We evaluated VTE rates, severity, timing, and risk factors in PAC patients as well as AT rates and initiation …

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