John A. Hickman

Human and financial consequences of herding in oncology drug development: clinical trials of TIGIT inhibitors

Emily S Zhang, Leeza Osipenko, John A. Hickman

Objectives: To illustrate and quantitate how herding in oncology drug development (five or more biopharmaceutical companies competing to develop modulators of an identical target) amplifies the number of patients enrolled in clinical trials of experimental drugs, and to estimate the cost of …

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Stabilized method for contact mechanics and dissipative interfacial kinematic processes

John A. Hickman, Scott Roberts, Arif Masud

This paper presents an interface stabilized method for contact mechanics and interfacial frictional processes between two elastic bodies. The unique aspect of the method is its variational coupling of the interacting surfaces, eliminating the need for master-slave type algorithms. Method is developed …

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Stabilized Method for Contact Mechanics and Dissipative Interfacial Kinematic Processes

Arif Masud, John A. Hickman, Scott Alan Roberts

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S483 “But I Don’t Eat That!”: Enhancing Pre-Endoscopy Bowel Preparation Instructions With Culturally Sensitive Nutrition Information

John A. Hickman, Rebecca Haug, Tracy Downs, R. A. Bayliss et autres

Introduction: Adequate bowel preparation is essential for optimal visualization during endoscopic procedures. Most bowel preparation instructions advocate for a low residue/low fiber diet leading up to endoscopy. Instructions are typically based on a Western diet and may not address cultural factors that …

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TOpCLASS Expert Consensus Classification of Perianal Fistulising Crohn’s Disease: A Real-world Application in a Serial Fistula MRI Cohort

Matthew Schroeder, Suha Abushamma, Alvin T George, Balakrishna Ravella et autres

BACKGROUND AND AIMS: Perianal fistuliing Crohn's disease [PFCD] is an aggressive phenotype of Crohn's disease defined by frequent relapses and disabling symptoms. A novel consensus classification system was recently outlined by the TOpCLASS consortium, which seeks to unify disease severity with patient-centred …

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Geldof Expert Consensus Classification of Perianal Fistulizing Crohn’s Disease: A Real-World Application in a Serial Fistula MRI Cohort

Matthew Schroeder, Suha Abushamma, Alvin T George, Ravella Balakrishna et autres

Background and Aims: Perianal fistulizing Crohn's disease (CD-PAF) is an aggressive phenotype of Crohn's disease (CD) defined by frequent relapses and disabling symptoms. A novel consensus classification system was recently outlined by Geldof et al. that seeks to unify disease severity with …

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RADIOLOGIST PERFORMANCE AND RELIABILITY OF MR SCORING SYSTEMS IN PERIANAL FISTULIZING CROHN’S DISEASE: RETROSPECTIVE ANALYSIS IN A REAL-WORLD CLINICAL PRACTICE

Jalpa Devi, Suha Abushamma, Jyoti Arora, Parakkal Deepak et autres

RADIOLOGIST PERFORMANCE AND RELIABILITY OF MR SCORING SYSTEMS IN PERIANAL FISTULIZING CROHN’S DISEASE: RETROSPECTIVE ANALYSIS IN A REAL-WORLD CLINICAL PRACTICE

Jalpa Devi, Suha Abushamma, Jyoti Arora, Parakkal Deepak et autres

Abstract BACKGROUND Perianal fistulizing Crohn’s disease (CD-PAF) is difficult to treat, and several MR scoring systems have been developed to assess treatment response. OBJECTIVE To assess the relationship between CD-PAF MR scoring systems and radiologists’ subjective assessment of CD-PAF severity and treatment …

Precision Medicine for Childhood Cancer: Current Limitations and Future Perspectives

Martin G. McCabe, Birgit Geoerger, Louis Chesler, Darren Hargrave et autres

Greater collaboration needed to realize potential of molecular profiling initiatives for pediatric cancers.

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Radiologist Performance and Reliability of MR Scoring Systems in Perianal Fistulizing Crohn’s Disease: Retrospective Analysis in a Real-World Clinical Practice

Suha Abushamma, Ravella Balakrishna, Alvin George, John A. Hickman et autres

Abstract Background Perianal fistulizing Crohn’s disease (CD-PAF) is difficult to treat, and several MR scoring systems have been developed to assess treatment response. Objective To assess the relationship between CD-PAF MR scoring systems and radiologists’ subjective assessment of CD-PAF severity and treatment …

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Costs and Causes of Oncology Drug Attrition With the Example of Insulin-Like Growth Factor-1 Receptor Inhibitors

Valerie Jentzsch, Leeza Osipenko, Jack W. Scannell, John A. Hickman

Importance: The development of oncology drugs is expensive and beset by a high attrition rate. Analysis of the costs and causes of translational failure may help to reduce attrition and permit the more appropriate use of resources to reduce mortality from cancer. …

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Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Mark Edwards, Gordon Forbes, Neil Walker, Dion Morton et autres

INTRODUCTION: Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems. Optimal management of perioperative intravenous fluids may reduce mortality rates and improve outcomes from surgery. Previous small trials of cardiac-output guided haemodynamic therapy …

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