Annalisa Loizedda

TYK2 : p.Pro1104Ala Variant Protects Against Autoimmunity by Modulating Immune Cell Levels

Maristella Steri, Valeria Orrù, Carlo Sidore, Antonella Mulas et autres

The TYK2:p.Pro1104Ala (rs34536443) hypomorph variant has been associated with protection against numerous autoimmune disorders. Thus, its mechanism of action becomes of great interest. Here, consistent with the participation of activated immune cells in autoimmunity, we show that the variant regulates the levels …

it, us (code pays fourni par la source)

TYK2:p.Pro1104Ala variant protects against autoimmunity by modulating immune cell levels

Maristella Steri, Valeria Orrù, Carlo Sidore, Antonella Mulas et autres

The TYK2 :p.Pro1104Ala (rs34536443) hypomorph variant has been associated with protection against numerous autoimmune disorders. Thus, its mechanism of action becomes of great interest. Here, consistent with the participation of activated immune cells in autoimmunity, we show that the variant regulates the …

it, us (code pays fourni par la source)

Implications of disease-modifying therapies for multiple sclerosis on immune cells and response to COVID-19 vaccination

Valeria Orrù, Valentina Serra, Michele Marongiu, Sandra Lai et autres

Introduction: Disease-modifying therapies (DMTs) have been shown to improve disease outcomes in multiple sclerosis (MS) patients. They may also impair the immune response to vaccines, including the SARS-CoV-2 vaccine. However, available data on both the intrinsic immune effects of DMTs and their …

it (code pays fourni par la source)

Cross-sectional analysis of the humoral response after SARS-CoV-2 vaccination in Sardinian multiple sclerosis patients, a follow-up study

Maria Laura Idda, Maristella Pitzalis, Valeria Lodde, Annalisa Loizedda et autres

Monitoring immune responses to SARS-CoV-2 vaccination and its clinical efficacy over time in Multiple Sclerosis (MS) patients treated with disease-modifying therapies (DMTs) help to establish the optimal strategies to ensure adequate COVID-19 protection without compromising disease control offered by DMTs. Following our …

it (code pays fourni par la source)

Cross-sectional analysis of the humoral response after SARS-CoV-2 vaccination in Sardinian Multiple Sclerosis patients, a follow-up study

Maria Laura Idda, Maristella Pitzalis, Valeria Lodde, Annalisa Loizedda et autres

Abstract Monitoring immune responses to SARS-CoV-2 vaccination and its clinical efficacy over time in Multiple Sclerosis (MS) patients treated with disease-modifying therapies (DMTs) help to establish the optimal strategies to ensure adequate COVID-19 protection without compromising disease control offered by DMTs. Following …

it (code pays fourni par la source)

Effect of Different Disease-Modifying Therapies on Humoral Response to BNT162b2 Vaccine in Sardinian Multiple Sclerosis Patients

Maristella Pitzalis, Maria Laura Idda, Valeria Lodde, Annalisa Loizedda et autres

Objectives: Vaccination against COVID-19 is highly recommended to patients affected by multiple sclerosis (MS); however, the impact of MS disease-modifying therapies (DMTs) on the immune response following vaccination has been only partially investigated. Here, we aimed to elucidate the effect of DMTs …

it (code pays fourni par la source)

Effect of different disease-modifying therapies on humoral response to BNT162b2 vaccine in Sardinian multiple sclerosis patients

Maristella Pitzalis, Maria Laura Idda, Valeria Lodde, Annalisa Loizedda et autres

Abstract Objectives Vaccination against COVID-19 is highly recommended to patients affected by multiple sclerosis (MS); however, the impact of MS disease-modifying therapies (DMTs) on the immune response following vaccination has been only partially investigated. Here, we aimed to elucidate the effect of …

us, it (code pays fourni par la source)

Involvement of microRNAs in Lithium Response in Patients With Bipolar Disorder and Related Phenotypes

Claudia Pisanu, Donatella Congiu, Giovanni Severino, Paola Niola et autres

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PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity

Carlo Sidore, Valeria Orrù, Eleonora Cocco, Maristella Steri et autres

Background: Defective alleles within the PRF1 gene, encoding the pore-forming protein perforin, in combination with environmental factors, cause familial type 2 hemophagocytic lymphohistiocytosis (FHL2), a rare, severe autosomal recessive childhood disorder characterized by massive release of cytokines—cytokine storm. Objective: The aim of …

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Author Correction: Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

Valeria Orrù, Maristella Steri, Carlo Sidore, Michele Marongiu et autres

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Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

Valeria Orrù, Maristella Steri, Carlo Sidore, Michele Marongiu et autres

it, gb, us (code pays fourni par la source)

P.305 Convergent sequencing and microarray data analyses suggest the involvement of miRNAs and target mRNAs in lithium response in bipolar disorder

Alessio Squassina, Claudia Pisanu, Eleni Merkouri Papadima, Claudio Melis et autres

it (code pays fourni par la source)