Accès ouvert
2023
article
OpenAlex
Farhan Anwar, Marielle Clark, J. Page Lindsey, Rachel Claus-Walker et autres
Background Clostridioides difficile Infection (CDI) is a healthcare-associated diarrheal disease prevalent worldwide. A common diagnostic algorithm relies on a two-step protocol that employs stool enzyme immunoassays (EIAs) to detect the pathogen, and its toxins, respectively. Active CDI is deemed less likely when …
us
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Accès ouvert
2020
article
OpenAlex
Bryan Angelo P. Roxas, Jennifer Lising Roxas, Rachel Claus-Walker, Anusha Harishankar et autres
Clostridioides difficile infection (CDI) is a major healthcare-associated diarrheal disease. Consistent with trends across the United States, C. difficile RT106 was the second-most prevalent molecular type in our surveillance in Arizona from 2015 to 2018. A representative RT106 strain displayed robust virulence …
us
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Accès ouvert
2020
preprint
OpenAlex
Bryan Angelo P. Roxas, Jennifer Lising Roxas, Rachel Claus-Walker, Anusha Harishankar et autres
ABSTRACT Background Clostridioides difficile RT106 has emerged as a dominant molecular type in the USA in recent years, but the underlying factors contributing to its predominance remain undefined. As part of our ongoing C. difficile infection (CDI) surveillance in Arizona, we monitored …
us
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2019
article
OpenAlex
Asad Mansoor, Navid Mahabadi
The volume of distribution (Vd) is a pharmacokinetic parameter representing an individual drug’s propensity to either remain in the plasma or redistribute to other tissue compartments. By definition, Vd is a proportionality constant that relates the total amount of drug in the …
us
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Accès ouvert
2018
article
OpenAlex
Gayatri Vedantam, Joshua A. Kochanowsky, J. Page Lindsey, Michael Mallozzi et autres
Morbidity and mortality attributed to Clostridium difficile infection (CDI) have increased over the past 20 years. Currently, antibiotics are the only US FDA-approved treatment for primary C. difficile infection, and these are, ironically, associated with disease relapse and the threat of burgeoning …
us
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2018
article
OpenAlex
Jennifer Lising Roxas, Ross Monasky, Bryan Angelo P. Roxas, Al Agellon et autres
Accès ouvert
2018
article
OpenAlex
Jennifer Lising Roxas, Ross Monasky, Bryan Angelo P. Roxas, Al Agellon et autres
Background & Aims The diarrheagenic pathogen, enteropathogenic Escherichia coli (EPEC), uses a type III secretion system to deliver effector molecules into intestinal epithelial cells (IECs). While exploring the basis for the lateral membrane separation of EPEC-infected IECs, we observed infection-induced loss of …
us
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Accès ouvert
2012
article
OpenAlex
F. K. Mohammad, Asad Mansoor, M. H. I. Al-Zubaidy
Limited information is available on the pharmacokinetics and bioavailability of aspirin and acetaminophen in young chicks. The purpose of the present study was to examine the pharmacokinetics of acetyl salicylic acid (aspirin) and acetaminophen in 12-day old chicks after a single intraperitoneal …
iq
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