Satoshi Oikawa

Mitochondrial control of amino acid catabolism by a fasting-inducible mitochondrial carrier

Satoshi Oikawa, Tadashi Yamamuro, Hiroshi Nishida, Daisuke Katoh et autres

Metabolic adaptation to nutrient deprivation requires coordinated control of mitochondrial anaplerosis and cataplerosis; however, how metabolite flux across the mitochondrial membrane is regulated during fasting remains less defined. Here, we report SLC25A34 as a fasting-inducible mitochondrial carrier that is highly expressed in …

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Mitochondrial control of amino acid catabolism by a fasting-inducible mitochondrial carrier

Satoshi Oikawa, Tadashi Yamamuro, Hiroshi Nishida, Daisuke Katoh et autres

Metabolic adaptation to nutrient deprivation requires coordinated control of mitochondrial anaplerosis and cataplerosis; however, how metabolite flux across the mitochondrial membrane is regulated during fasting remains less defined. Here, we report SLC25A34 as a fasting-inducible mitochondrial carrier that is highly expressed in …

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Mitochondrial control of glycerolipid synthesis by a PEP shuttle

Tadashi Yamamuro, Daisuke Katoh, Guilherme Pereira da Silva, Hiroshi Nishida et autres

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Mitochondrial control of glycerolipid synthesis by a PEP shuttle

Tadashi Yamamuro, Daisuke Katoh, Guilherme Martins Silva, Hiroshi Nishida et autres

Mitochondria provide a variety of metabolites, in addition to ATP, to meet cell-specific needs. One such metabolite is phosphoenolpyruvate (PEP), which contains a higher-energy phosphate bond than ATP and has diverse biological functions. However, how mitochondria-generated PEP is delivered to the cytosol …

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Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue

Christopher Auger, Mark Li, Masanori Fujimoto, Kenji Ikeda et autres

import that plays a key role in UCP1-independent thermogenesis and energy balance.

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The utility of ESMI in assessing skeletal muscle mass in patients with liver disease

A. Naganuma, Yuhei Suzuki, Takao Hoshino, IKEI INUKAI et autres

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The Rubicon–WIPI axis regulates exosome biogenesis during ageing

Kyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita et autres

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Remodelling of the translatome controls diet and its impact on tumorigenesis

Haojun Yang, Vincenzo Andrea Zingaro, James Lincoff, Harrison Tom et autres

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Roles of programmed death‐1 and muscle innate lymphoid cell‐derived interleukin 13 in sepsis‐induced intensive care unit‐acquired weakness

Yuichi Akama, Eun Jeong Park, Naoko Satoh‐Takayama, Atsushi Ito et autres

BACKGROUND: Intensive care unit-acquired weakness (ICU-AW) is a syndrome characterized by a long-term muscle weakness often observed in sepsis-surviving patients during the chronic phase. Although ICU-AW is independently associated with increased mortality, effective therapies have yet to be established. Programmed death-1 (PD-1) …

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The Rubicon-WIPI axis regulates exosome biogenesis during aging

Kyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita et autres

Abstract Cells release intraluminal vesicles (ILVs) in multivesicular bodies as exosomes to communicate with other cells. Although recent studies suggest an intimate link between exosome biogenesis and autophagy, the detailed mechanism is not fully understood. Here we employed comprehensive RNAi screening for …

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BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis

Anthony R.P. Verkerke, Dandan Wang, Naofumi Yoshida, Zachary Taxin et autres

Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT thermogenesis is tightly associated with increased energy expenditure, reduced body weight, and improved glucose homeostasis. However, human BAT is protective against type 2 diabetes, independent of body …

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Skeletal muscle‐enriched miRNAs are highly unstable in vivo and may be regulated in a Dicer‐independent manner

Satoshi Oikawa, Shuaibang Yuan, Yoshio Kato, Takayuki Akimoto

MicroRNAs (miRNAs) are small noncoding RNAs that control essential cellular processes. For several decades, the molecular mechanisms underlying the functions and biogenesis of miRNAs have been clarified, whereas the molecular dynamics of miRNAs are poorly understood. We recently found that muscle-enriched miRNAs …

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