Accès ouvert
2026
article
OpenAlex
Austin J. Graham, Michelle W.L. Khoo, Vasudha Srivastava, Sara Viragova et autres
Complex and robust tissue self-organization requires defined initial conditions and dynamic boundaries-neighbouring tissues and extracellular matrix that actively evolve to guide morphogenesis. A major challenge in tissue engineering is identifying material properties that are compatible with controlling initial culture conditions while mimicking …
us
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Accès ouvert
2024
article
OpenAlex
Bruno Lopes-Bastos, Joana Nabais, Tânia Ferreira, Giulia Allavena et autres
tumors exhibit reduced cell proliferation, increased apoptosis, and melanocyte differentiation. Notably, these tumors show enhanced immune cell infiltration and can resume growth when transplanted into immunocompromised hosts. We propose that telomerase is required for melanoma in zebrafish, albeit at later stages of …
fr, pt, cn
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Accès ouvert
2024
preprint
OpenAlex
Austin J. Graham, Michelle W.L. Khoo, Vasudha Srivastava, Sara Viragova et autres
Complex and robust self-organization requires defined initial conditions and dynamic boundaries - neighboring tissues and extracellular matrix (ECM) that actively evolve to guide morphogenesis. A major challenge in tissue engineering is identifying material properties that mimic dynamic tissue boundaries but that are …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Mounir El Maï, Malia Bird, Asma Allouche, Seniye Targen et autres
Abstract Telomere shortening is a hallmark of aging and is counteracted by telomerase. As in humans, the zebrafish gut is one of the organs with the fastest rate of telomere decline, triggering early tissue dysfunction during normal zebrafish aging and in prematurely …
fr, pt, cn
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Bruno Lopes-Bastos, Joana Nabais, Tânia Ferreira, Mounir El Maï et autres
Abstract Most cancers reactivate telomerase to maintain telomere length to acquire immortality. The importance of this process is well illustrated by the fact that telomerase promoter mutations are found at a high frequency in many cancer types, including melanoma. However, it is …
fr, pt, cn
(code pays fourni par la source)
2022
conference-abstract
OpenAlex
Kendra D. Marr, Beatrice S. Knudsen, Jaime M.C. Gard, Malia Bird et autres
Abstract Overtreatment of prostate cancer is a significant source of patient morbidity and cost. The human prostate is bounded by a smooth muscle capsule, and aggressive tumors invade through the muscle layer, called extracapsular extension (ECE), to escape organ confinement. The presence …
us
(code pays fourni par la source)