Gerald F. Giesbrecht

Prenatal distress, infant cerebellar asymmetry, and early developmental outcomes

Alissa Papadopoulos, Emily S. Nichols, Eun Jung Choi, Lianne Tomfohr‐Madsen et autres

Prenatal psychological distress is associated with altered brain development and adverse outcomes in offspring. The cerebellum is particularly vulnerable, and structural alterations associated with developmental deficits in children. This study examined the relationships between prenatal anxiety and depression, cerebellar asymmetry, and infant …

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Building Emotional Awareness and Mental Health in Parenting (BEAM): protocol for a parallel-group randomized controlled non-inferiority trial for an app based intervention to improve postpartum mental health and support children’s brain development in Western Canada

Lianne Tomfohr‐Madsen, Leslie E. Roos, Ariana M. Martinez, Hayal Muslu et autres

BACKGROUND: Symptoms of depression, anxiety and anger are common amongst parents and are associated with increased risk of offspring mental health problems and differences in child brain development. Many parents do not access treatment, in part due to expense, wait times, and …

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Exploring the Early-Life Microbiomes of Preterm Infants and Their Childhood Health Outcomes (The BLOOM Study): Protocol for a Prospective, Observational Cohort Study

Michelle R Asbury, Andrea Guedez, Jessica Lee, Emily M. Mercer et autres

Background: Establishment of the gut microbiome during the first years of life is critically important for long-term health and development. In preterm infants, microbial colonization is disrupted due to their developmental immaturity and the myriad of pre- and postnatal exposures. Unfortunately, this …

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129. Influence of Prenatal Anxiety and Depression on Trajectories of Child Brain Network Connectivity Across the First 3 Years of Life

Aliza Jaffer, Kathryn Y. Manning, Gerald F. Giesbrecht, Lianne Tomfohr-Madsen et autres

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A Longitudinal Study of Children's Hippocampal Development: Investigating Maternal Physical Activity, Depression, and Education

Arash Aghamohammadi‐Sereshki, Jess E. Reynolds, Merv Singh, Jamie Roeske et autres

The developing hippocampus is particularly sensitive to early environmental influences, including during pregnancy. This longitudinal neuroimaging study examined associations between prenatal maternal physical activity and depression, maternal education, and hippocampal development from early childhood to early adolescence. Participants were mothers and their …

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Longitudinal predictors of attachment disorganization: Sociodemographic risk and maternal disrupted caregiving

Jessica E. Cooke, Nicole Racine, Gerald F. Giesbrecht, André Plamondon et autres

Abstract Attachment disorganization has enduring consequences for children’s socioemotional health. Although disrupted caregiving (e.g., frightening or intrusive behaviors) is a strong antecedent of attachment disorganization, much of its variance remains unexplained, highlighting the need to identify additional precursors. This longitudinal study examined …

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The BLOOM Study: Protocol for a prospective, observational cohort study exploring the early-life microbiomes of preterm infants and their childhood health outcomes

Michelle R. Asbury, Andrea G. Guedez, Jessica P. Lee, Emily M. Mercer et autres

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Are Maternal Adverse Childhood Experiences Associated with Their Preschool Children’s Sleep Disruptions? Longitudinal Mediation Through Mothers’ Depressive Symptoms and Children’s Screen Time

Stefan Kurbatfinski, Lalith Nandakumar, Janelle Boram Lee, Gerald F. Giesbrecht et autres

BACKGROUND: Children of mothers exposed to adverse childhood experiences (ACEs) may be at increased risk of sleep disruptions, such as night waking, due to potential suboptimal caregiving or living conditions. Mothers' ACEs are also associated with maternal depressive symptoms, which in turn …

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The Online Assessment of Emotional Knowledge in Toddlerhood

Janelle Bobula, Cynthia Côté, Amber Cook, Tasmia Hai et autres

ABSTRACT Emotional knowledge (EK) is broadly defined as the ability to identify and understand emotions. Despite being recognized as a foundational component of socioemotional development in childhood, early emergence of EK is seldom explored before age 3. Similarly, research has yet to …

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Epigenetic Insights into the Impact of Disaster-Related Prenatal Stress: A Narrative Review

Lei Cao-Lei, Daphne M. Vrantsidis, Gerald F. Giesbrecht

Disaster-related prenatal maternal stress, whether due to natural or human-made crises, can have profound effects on offspring health and development. This narrative review synthesizes research findings on the epigenetic mechanisms through which prenatal maternal stress influences long-term offspring health outcomes. Focusing primarily …

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Establishment of the gut microbiome in preterm infants is associated with exposure to stress-inducing medical interventions

Emily M. Mercer, Sarah Piche-Choquette, Julia Gorospe, Zahra Rangipour et autres

The gut microbiome of preterm infants follows distinct maturational trajectories relative to that of term infants, largely determined by gestational age at birth. While the development of the bacterial microbiome in preterm infants has been characterized in the context of known microbiome-modifying …

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Impact of Prenatal Activity on Child Growth Trajectories: Findings from the APrON Study

Brittany A. Matenchuk, Laura Osachoff, Chenxi Cai, Rhonda C. Bell et autres

PURPOSE: This study aimed to examine the impact of prenatal physical activity on child growth from birth to 3 years. METHODS: Data were obtained from a subset of the Alberta Pregnancy Outcomes and Nutrition cohort ( N = 1725). Prenatal physical activity …

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