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Kiani J.C. Jacobs, Eric C. Leszczynski, Charles S. Schwartz, Michael J. Pitre et autres
us, hr (code pays fourni par la source)
Zsuzsanna Kuklenyik, Anna A. Ivanova, Lauren E. Drinkard, David Schieltz et autres
Abstract High-density and low-density lipoproteins (HDL and LDL) are established analytical targets for diagnosis and risk stratification of numerous chronic diseases. This study investigates potential sources of bias in lipoprotein particle counting (HDL-P and LDL-P), focusing on the most atheroprotective small-HDL and …
us (code pays fourni par la source)
Seong-Hyun Kim, Melissa A. Quinn, Julian Ananyev, Ashley C. McPeek et autres
INTRODUCTION: Childhood growth restriction can lead to lasting developmental changes, increasing susceptibility to chronic diseases and neurodegenerative conditions in adulthood. High-intensity interval training (HIIT) elevates brain-derived neurotrophic factor (BDNF) levels more effectively than moderate-intensity continuous exercise, supporting neuroplasticity. Building on these findings, …
us (code pays fourni par la source)
Eric C. Leszczynski, Charles S. Schwartz, Kiani J.C. Jacobs, Prasun K. Dev et autres
The HDL-specific phospholipid efflux (HDL-SPE) assay is a novel cell-free measure of HDL function that is inversely associated with coronary artery disease. However, the effect of exercise training on HDL-SPE is unknown. The purpose of this study was to examine the effect …
us, jp (code pays fourni par la source)
Prashant Rao, Eric C. Leszczynski, Michael Mi, Jacob L. Barber et autres
Background: Few studies have systematically evaluated whether adaptations to endurance training differ by sex. We assessed sex differences in cardiopulmonary, body composition, and metabolic adaptations among male and female sedentary adults following a 20-week endurance training program. Hypothesis: Male and female participants …
us, ca (code pays fourni par la source)
Matthew Herzig, Prasun K Dev, Eric C. Leszczynski, Jacob L. Barber et autres
Introduction: Plasma proteomics has been used to identify organ-specific aging signatures related to health and disease. It is unknown whether regular exercise can modulate predicted organ aging. Research Question: To examine whether proteomic aging signatures are modified by endurance exercise training (ET). …
us (code pays fourni par la source)
Seong-Hyun Kim, Melissa A. Quinn, Ashley C. McPeek, Eric C. Leszczynski
Postnatal growth-restriction (PNGR) leads to lasting deficits in growth and heart health, increasing the risk of cardiovascular disease in adulthood by 47%. Adverse cardiac changes, including fibrosis, have been reported in PNGR mice following voluntary wheel running. However, high-intensity interval training (HIIT) …
us (code pays fourni par la source)
Prasun Kumar Dev, Eric C. Leszczynski, Charles S. Schwartz, Jacob L. Barber et autres
INTRODUCTION: HDL particle functionality is influenced by its structure, including lipid composition. However, the effects of exercise training on the HDL lipidome and its relationship with HDL-related traits are largely unknown. OBJECTIVE: To investigate the HDL lipidome of 154 adults before and …
us (code pays fourni par la source)
Matthew Herzig, Prasun K Dev, Eric C. Leszczynski, Jacob L. Barber et autres
Introduction: A recent study utilized plasma proteins to identify organ-specific aging signatures that were related to health and disease. However, it is unknown whether exercise interventions can change predicted organ aging. Methods: We measured 4979 plasma proteins using the SomaScan assay before …
us (code pays fourni par la source)
Eric C. Leszczynski, Jacob L. Barber, Prashant Rao, Michael Mi et autres
Background: Sex differences in metabolites, particularly their changes with exercise training, are largely unknown. We hypothesized that metabolites would not largely differ between males and females at baseline, but that most of the exercised-induced changes in metabolites would be sex-specific. Methods: Plasma …
us (code pays fourni par la source)
Eric C. Leszczynski, Jacob L. Barber, Prashant Rao, Michael Mi et autres
Background: The proteome is altered in obesity and proteomic signatures of BMI have been identified. However, few studies have examined differences in clinical profiles between actual and protein-predicted BMI. Hypothesis: Plasma protein-based BMI classification will better capture cardiometabolic risk compared to actual …
us (code pays fourni par la source)
Prashant Rao, Christian Peterson, Jacob L. Barber, Michael Mi et autres
PURPOSE: Studies reporting on acute exercise responses typically involve more males than females and are underpowered to understand sex differences. Given recent efforts to understand the role of sex as a biological variable in biomedical research, we elucidate its impact on acute …
us (code pays fourni par la source)
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