George Lin

Does public education reduce ice storm-related carbon monoxide exposure?

George Lin, Gregory P. Conners

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Refractory Hypoglycemia from Ciprofloxacin and Glyburide Interaction

George Lin, Daniel P. Hays, Linda L. Spillane

Patients taking multiple medications may suffer from unpredictable and complex drug-drug interactions resulting in significant morbidity and mortality. There are few reports in the literature of hypoglycemia with concurrent administration of an oral hyperglycemic agent and a fluoroquinolone antibiotic. We present a …

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Hemoglobin Increases Endothelin-1 in Endothelial Cells by Decreasing Nitric Oxide

George Lin, Robert Loch Macdonald, Linda S. Marton, Andrew Kowalczuk et autres

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Adenoviral Gene Transfer of Nitric Oxide Synthase Increases Cerebral Blood Flow in Rats

Jürgen C. Lüders, Conrad Chris Weihl, George Lin, Ghanashayam Ghadge et autres

OBJECTIVE: Depletion of nitric oxide may play a role in the development of vasospasm after aneurysmal subarachnoid hemorrhage. Replenishment of nitric oxide might be a useful treatment for vasospasm. Using rats, we performed intracisternal injections of replication-defective adenovirus containing the endothelial nitric …

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Heme Oxygenase-1 and Ferritin are Increased in Cerebral Arteries after Subarachnoid Hemorrhage in Monkeys

Shigeki Ono, Zhen‐Du Zhang, Linda S. Marton, B. Yamini et autres

Hemoglobin is a key factor in the production of cerebral vasospasm. Metabolism of hemoglobin involves breakdown of heme by heme oxygenase (HO) and sequestration of the released iron in ferritin. We determined whether subarachnoid hemorrhage induces these proteins in cerebral arteries and, …

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Effect of Adenovirus-mediated Nitric Oxide Synthase Gene Transfer on Vasospasm after Experimental Subarachnoid Hemorrhage

Marcus Andrew Stoodley, Conrad Chris Weihl, Zhen-Du Zhang, George Lin et autres

OBJECTIVE: Evidence indicates that vasospasm after subarachnoid hemorrhage (SAH) is caused in part by a decrease in the vasodilator nitric oxide (NO), which is produced mainly in endothelial cells. This study tested whether intracisternal injection of adenovirus-expressing endothelial NO synthase (eNOS) would …

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Safety of Perioperative Subcutaneous Heparin for Prophylaxis of Venous Thromboembolism in Patients Undergoing Craniotomy

Robert Loch Macdonald, Chris Amidei, George Lin, Ilyas Munshi et autres

OBJECTIVE: To determine whether perioperative subcutaneous heparin is safe to use for patients undergoing craniotomy and to determine the incidence of venous thromboembolism in patients undergoing craniotomy. METHODS: Perioperative prophylaxis with subcutaneous heparin, 5000 U every 12 hours, was begun at induction …

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Gene Therapy for Cerebrovascular Disease

Chris Weihl, Robert Loch Macdonald, Marcus Andrew Stoodley, Jürgen C. Lüders et autres

OBJECTIVE: To review the principles of and the experimental and clinical results of gene therapy for cerebrovascular disease. METHODS: Literature review. RESULTS: Vectors for gene transfer into the brain or into the cerebral vasculature include naked plasmid deoxyribonucleic acid, cationic liposomes, and …

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Herbal Medicine for the Treatment of Cardiovascular Disease

Nick H. Mashour, George Lin, William H. Frishman

Herbs have been used as medical treatments since the beginning of civilization and some derivatives (eg, aspirin, reserpine, and digitalis) have become mainstays of human pharmacotherapy. For cardiovascular diseases, herbal treatments have been used in patients with congestive heart failure, systolic hypertension, …

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Herbal medicine for the treatment of cardiovascular disease: clinical considerations.

Nick H. Mashour, George Lin, William H. Frishman

Herbs have been used as medical treatments since the beginning of civilization and some derivatives (eg, aspirin, reserpine, and digitalis) have become mainstays of human pharmacotherapy. For cardiovascular diseases, herbal treatments have been used in patients with congestive heart failure, systolic hypertension, …

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Effect of Adenoviral Nitric Oxide Synthase Gene Transfer on Vasospasm after Subarachnoid Hemorrhage

Robert Loch Macdonald, Ghanashayam Ghadge, Chris Weihl, Marcusr Stoodley et autres

Prevention of Vasospasm after Subarachnoid Hemorrhage in Dogs by Continuous Intravenous Infusion of PD156707

Robert Loch Macdonald, Lydia Johns, George Lin, Linda S. Marton et autres

This randomized, blinded study tested the prophylactic effect of PD156707, a nonpeptide competitive antagonist of endothelin A receptors, against vasospasm after subarachnoid hemorrhage in dogs. Twenty-two dogs were allocated on day 0 to undergo cerebral angiography followed by injection of arterial blood …

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