Bianca Pourmussa

Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction

Minkwan Kim, Vinayak Subramanian, Hamed Tavolinejad, Mateo Sarmiento Bustamante et autres

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is common in heart failure with preserved ejection fraction (HFpEF). However, the proteomic signatures linked to CHIP driver mutations and their prognostic implications in HFpEF remain poorly defined. We aimed to identify plasma protein signatures …

kr, us, sg, nz, be, nl (code pays fourni par la source)

Clonal hematopoiesis of indeterminate potential risk score for predicting clinical outcome in patients with heart failure with preserved ejection fraction

M Kim, V Subramanian, A Pandey, Julio A. Chirinos et autres

Abstract Background Clonal hematopoiesis of indeterminate potential (CHIP) is prevalent among patients with heart failure with preserved ejection fraction (HFpEF) and has been linked to systemic inflammation. However, the plasma proteomic profiles associated with specific CHIP driver mutations and their prognostic relevance …

kr, us (code pays fourni par la source)

Anisotropy, heterogeneity, and limited sex differences in aortic suture retention

Gabrielle X. Lohrenz, Bianca Pourmussa, Haviva M. Goldman, Brooks A. Lane et autres

us (code pays fourni par la source)

Calcium Channel Blockade Versus β-Blockade for Hypertension in Heart Failure With Preserved Ejection Fraction: A Randomized Crossover Trial

Jordana B. Cohen, Alavi Hossain, Jesse Chittams, Manyun Zhao et autres

BACKGROUND: Hypertension is present in 90% of individuals with heart failure with preserved ejection fraction (HFpEF) and is a major modifiable risk factor for the development of HFpEF. However, randomized controlled trial evidence for hypertension management in HFpEF is limited. METHODS: In …

us (code pays fourni par la source)

Anisotropy, Heterogeneity, and Limited Sex Differences in Aortic Suture Retention

Gabrielle X. Lohrenz, Bianca Pourmussa, Haviva M. Goldman, Brooks A. Lane et autres

us (code pays fourni par la source)

Ascending Aortic Dimensions and Body Size

Hamed Tavolinejad, Cameron Beeche, Marie‐Joe Dib, Bianca Pourmussa et autres

us (code pays fourni par la source)

Proteome‐Wide Mendelian Randomization Identifies Natriuretic Peptide‐B and Novel Proteins as Potential Regulators of Pulse Pressure in Humans

Marie‐Joe Dib, Devendra Meena, James Yarmolinsky, Joe David Azzo et autres

Background Large‐artery stiffness (LAS) significantly contributes to cardiovascular morbidity and death and is characterized by increased pulse pressure (PP). The biology underlying large‐artery stiffness in humans remains incompletely understood. Methods and Results We investigated associations between PP and circulating levels of 2941 …

us, gb (code pays fourni par la source)

Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences

Cameron Beeche, Bingxin Zhao, Hamed Tavolinejad, Bianca Pourmussa et autres

BACKGROUND: Vascular aging is an important phenotype characterized by structural and geometric remodeling. Some individuals exhibit supernormal vascular aging, associated with improved cardiovascular outcomes; others experience early vascular aging, linked to adverse cardiovascular outcomes. The aorta is the artery that exhibits the …

us, ru (code pays fourni par la source)

Cardio-Ankle Vascular Index as a Marker of Arterial Stiffness: Principles, Application, and Clinical Utility

Hamed Tavolinejad, Bianca Pourmussa, Julio A. Chirinos

Large artery stiffness (LAS) is widely recognized as a highly clinically relevant determinant of cardiovascular health and an independent prognostic marker. However, routine assessment of LAS has not yet been integrated into clinical practice. Arterial wall stiffness is dependent on distending pressure …

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Short Report: Hospitalization for New-Onset Heart Failure in Survivors of Hospitalized COVID-19

Vicente Corrales‐Medina, Jordana B. Cohen, Seavmeiyin Kun, Bianca Pourmussa et autres

AIMS: Previous studies have reported an incidence of new-onset heart failure (HF) among COVID-19 survivors ranging from 0.7 to 8.5 per 100 person-years, but they relied on administrative data for outcome ascertainment. Given the public health implications, a more accurate characterization of …

ca, us (code pays fourni par la source)

Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction

Senthil Selvaraj, Antoneta Karaj, Julio A. Chirinos, Nicole Denney et autres

BACKGROUND: The etiology of exercise intolerance in heart failure with preserved ejection fraction (HFpEF) is multifactorial. Several contributing pathways may be improved by ketone ester (KE). OBJECTIVES: This study aims to determine whether KE improves exercise tolerance in HFpEF. METHODS: ) during …

us (code pays fourni par la source)

FUEL UTILIZATION DURING EXERCISE WITH EXOGENOUS KETONES VERSUS PLACEBO IN HEART FAILURE WITH PRESERVED EJECTION FRACTION: KETO-HFPEF

Senthil Selvaraj, Antoneta Karaj, Julio A. Chirinos, Nicole Denney et autres