Sandie Munier

Ensemble-Based Reconstruction and Prioritization of Binding Sites in Influenza A Nucleoprotein

Xinyu Qi, Inés Sabine Rahali, Sandie Munier, Anne Badel et autres

Influenza A nucleoprotein (NP) is essential for viral RNA binding, ribonucleoprotein assembly, and NP oligomerization, making it an attractive antiviral target; however, static structures incompletely capture the conformational variability governing pocket formation and accessibility. Here, 17,178 pockets detected across 753 monomeric NP …

fr (code pays fourni par la source)

Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in Rhinolophus and human cells

Ségolène Gracias, Elodie Le Seac’h, Samuel Donaire-Carpio, Françoise Vuillier et autres

Abstract Asian Rhinolophus bats are considered the natural reservoirs of an ancestral SARS-CoV-2. However, the biology of SARS-CoV-2-related viruses in bat cells is not well understood. Here, we investigated the replication of BANAL-236, the only bat-derived SARS-CoV-2 relative isolated to date, in …

fr, us, es, de (code pays fourni par la source)

The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection

Sophie Desgraupes, Adrien Decorsière, Suzon Perrin, Benoît Gouy et autres

Influenza virus infections can cause severe complications such as Acute Necrotizing Encephalopathy (ANE), which is characterised by a rapid onset of pathological inflammation following febrile infection. Heterozygous dominant mutations in the nucleoporin RANBP2/Nup358 predispose to influenza-triggered ANE1. The aim of our study …

fr, ca (code pays fourni par la source)

The genetic driver of Acute Necrotizing Encephalopathy, RANBP2, regulates the inflammatory response to Influenza A virus infection

Nathalie Jane Arhel, Sophie Desgraupes, Benoît Gouy, Adrien Decorsière et autres

fr, ca (code pays fourni par la source)

Multimodal SARS-CoV-2 interactome sketches the virus-host spatial organization

Guillaume Dugied, Estelle M. N. Laurent, Mikaël Attia, Jean‐Pascal Gimeno et autres

An accurate spatial representation of protein-protein interaction networks is needed to achieve a realistic and biologically relevant representation of interactomes. Here, we leveraged the spatial information included in Proximity-Dependent Biotin Identification (BioID) interactomes of SARS-CoV-2 proteins to calculate weighted distances and model …

fr, ca, es, gr, de (code pays fourni par la source)

Levels and functionality of Pacific Islanders’ hybrid humoral immune response to BNT162b2 vaccination and delta/omicron infection: A cohort study in New Caledonia

Catherine Inizan, A. M. Courtot, Chloé Sturmach, Anne-Fleur Griffon et autres

BACKGROUND: Pacific Islanders are underrepresented in vaccine efficacy trials. Few studies describe their immune response to COVID-19 vaccination. Yet, this characterization is crucial to re-enforce vaccination strategies adapted to Pacific Islanders singularities. METHODS AND FINDINGS: We evaluated the humoral immune response of …

nc, fr, Nigéria (code pays fourni par la source)

Horseshoe bats from Southeast Asia host a high diversity of Sarbecoviruses, including close ancestors of SARS-CoV-2

Sarah Temmam, Khamsing Vongphayloth, Tran Cong Tu, Béatrice Regnault et autres

International audience

Hybrid humoral immune response of Pacific Islanders to BNT162b2 vaccination and Delta/Omicron infection: a cohort study

Catherine Inizan, A. M. Courtot, Chloé Sturmach, Anne-Fleur Griffon et autres

Summary Background Pacific Islanders are underrepresented in vaccine efficacy trials. Few studies describe their immune response to COVID-19 vaccination. Yet, this characterization is crucial to re-enforce vaccination strategies adapted to Pacific Islanders singularities. Methods We evaluated the humoral immune response of 585 …

fr, nc, us, Nigéria (code pays fourni par la source)

Neutralizing and enhancing monoclonal antibodies in SARS-CoV-2 convalescent patients: lessons from early variant infection and impact on shaping emerging variants

Frédéric Coutant, Franck Touret, Jean‐Jacques Pin, Marina Alonzo et autres

Serological studies of COVID-19 convalescent patients have identified polyclonal lineage-specific and cross-reactive antibodies (Abs), with varying effector functions against virus variants.Individual specificities of anti-SARS-CoV-2 Abs and their impact on infectivity by other variants have been little investigated to date.Here, we dissected at …

fr (code pays fourni par la source)

Author Correction: Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

Guilherme Dias de Melo, Victoire Perraud, Flavio Alvarez, Alba Vieites Prado et autres

The original version read “Here we show that all evaluated SARS-CoV-2 viruses (Wuhan, Gamma, Delta and Omicron/BA.1), including novel generated recombinant SARS-CoV-2, are able to invade the brain, most likely via the olfactory nerves, and of promoting inflammation in the nervous tissue.”

fr, ch (code pays fourni par la source)

Impact of influenza immunity on the mortality among older adults hospitalized with COVID-19: a retrospective cohort study

Matthieu Coulongeat, Julien Marlet, Amal Aïdoud, Flora Donati et autres

fr (code pays fourni par la source)

Sotrovimab therapy elicits antiviral activities against Omicron BQ.1.1 and XBB.1.5 in sera of immunocompromised patients

Timothée Bruel, Lou-Léna Vrignaud, Françoise Porrot, Isabelle Staropoli et autres

fr (code pays fourni par la source)