Jessica Strid

A novel Vδ1 engager targeting CD19 enhances human Vδ1 γδ T cell responses against CLL and CD19+ hematological malignancies

Shefali A Bhumbra, Robert Good, Antara Banerjee, Tyreese Hines et autres

γδ T cells are associated with favorable outcomes in many cancers likely through a mechanism of stress-directed cytotoxicity and antitumor cytokine production. Vδ1 γδ T cells are especially promising for immunotherapy due to their broad stress recognition and resistance to activation-induced cell …

jp, gb (code pays fourni par la source)

Measurement of immune cell-derived volatile organic compounds from ex vivo and in vitro cultures: a scoping review

Nader Habib Bedwani, Philip Kwan Hung Leung, Jane Zen, Yuki Agarwala et autres

BACKGROUND: Volatile organic compounds (VOCs) originate from cellular metabolic activity and disease-related biochemical processes and are emerging as non-invasive biomarkers. Although immune cells undergo marked metabolic and functional reprogramming during activation and differentiation, their contribution to the cellular volatile metabolome remains poorly …

gb (code pays fourni par la source)

MiRNAs in Interstitial Skin Fluid Sampled with Swellable Hydrogel Microneedles Are Locally Deregulated Near Malignant Skin Lesions in Early Stages of Cutaneous Squamous Cell Carcinoma

Ahmad Kenaan, Oliver Teenan, Connor Daniels, Christina Malaktou et autres

Interrogating molecular biomarkers in bodily fluids has emerged as a clinically useful strategy for the early diagnosis of many cancer types. Interstitial skin fluid is currently being explored as a possible alternative to blood, containing the same types of biomarkers but lacking …

gb (code pays fourni par la source)

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity

Kok Haw Jonathan Lim, Oliver Schulz, Irene Lobón, Tomas Castro‐Dopico et autres

Type 1 conventional dendritic cells (cDC1s) acquire and cross-present tumor antigens to prime CD8⁺ T cells. Whether this selects for specific neoantigens is unclear. DNGR-1 (CLEC9A), a cDC1 receptor for F-actin exposed on dead cells, promotes cross-presentation of cell-associated antigens. Here we …

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O18 The role of B cells and tertiary lymphoid structures for immune surveillance in cutaneous squamous cell carcinoma

Jennifer R. Shelley, Ester Fagnano, Holly Webster, Sophie Ward et autres

Abstract Introduction and aims Cutaneous squamous cell carcinoma (cSCC), the second most common form of skin cancer, has recently been associated with B- and T-cell clusters which resembled tertiary lymphoid structures (TLSs). These structures are of particular interest due to the lack …

gb (code pays fourni par la source)

P36 Investigating the role of the IgE–FcεRI axis in human cutaneous squamous cell carcinoma

Matin Dokht Ashoori, Holly Webster, Sophie Ward, Christina Malaktou et autres

Abstract Introduction and aims The IgE–FcεRI axis is primarily studied in the context of helminth infection and allergy. Here, we focus on IgE–FcεRI in skin cancer immune surveillance. We have previously shown in mouse models of cutaneous squamous cell carcinoma (cSCC) that …

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Role of Fibroblast‐Immune Crosstalk in Kidney, Lung, and Skin Tertiary Lymphoid Structures

Amy Rachael Cross, Jennifer R. Shelley, Rebecca Newman, Jessica Strid et autres

Tertiary lymphoid structures (TLSs) are organized aggregates of lymphocytes, myeloid cells, and stromal cells that form at sites of inflammation, providing adaptive immune responses outside of secondary lymphoid organs (SLOs). Found in various pathological conditions-including chronic infections, cancer, organ transplantation, autoimmune diseases, …

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The IL-33/ST2 axis and tissue Treg maintain epithelial homeostasis and restrain cancer development in the skin

Sophia Ward, Greg Crawford, Buang Norzawani, Christina Malactou et autres

Interleukin (IL)-33 is constitutively expressed in many epithelial tissues at steady state and signals through the receptor, ST2. IL-33 is released upon tissue injury and functions as an endogenous danger signal to alert the immune system to tissue damage. Here we investigate …

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Eosinophils and Bioactive Lipid Mediators Regulate Skin Inflammation and Cancer Growth

Christina Malactou, Mark David Hayes, Tingfeng Zhang, Sophia Ward et autres

Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer, with local immunity playing a key role in regulating outcome. Nonresolving inflammation has been suggested to drive cancer growth; however, a fundamental understanding of the tumor immune microenvironment …

gb (code pays fourni par la source)

Psychological Stress-Induced Local Immune Response to Food Antigens Increases Pain Signaling Across the Gut in Mice

Javier Aguilera‐Lizarraga, Cintya López-López, Josue Jaramillo-Polanco, Morgane V. Florens et autres

BACKGROUND & AIMS: We recently showed that a bacterial infection can break oral tolerance to food and lead to immunoglobulin E (IgE)-dependent mast cell activation and food-induced abdominal pain, which could constitute an important pathogenic mechanism in postinfectious irritable bowel syndrome (IBS). …

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Conserved Developmental Rewiring of the TCR Signalosome Drives Tolerance in Innate-Like Lymphocytes

Harriet J. Watt, Stefan Schattgen, Neema Skariah, Irene Saha et autres

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SWELLABLE HYDROGEL MICRONEEDLE PATCHES CAN INTERROGATE MIRNA COMPOSITION IN SKIN FLUID TO DIAGNOSE SKIN CANCER

Ahmad Kenaan, Oliver Teenan, Connor Daniels, Christina Malactou et autres

gb (code pays fourni par la source)