Stephan W. Aberle

Widespread circulation of Alongshan virus in Austria and serological evidence for infection in humans: a nationwide molecular and serological observational study

David M. Florian, Paul Jetzinger, Anna‐Margarita Schötta, Iris Medits et autres

BACKGROUND: Alongshan virus, a segmented RNA virus in the Jingmenvirus group of flaviviruses, was first identified in 2017 in China in patients with tick-borne encephalitis-like illness. Alongshan virus has since been detected in ticks and mammals in several European countries. In this …

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Increased incidence of human West Nile and Usutu infections in Austria, 2024: analysis of data from 2009 to 2024

David M. Florian, Jeremy V. Camp, Christof Jungbauer, Dirk Werber et autres

BACKGROUNDWest Nile virus (WNV) and Usutu virus (USUV) outbreaks in Europe pose growing public health concerns. In Austria, human WNV and USUV infections occur nearly every year since 2009 with notable case number variations.AIMWe analysed annual incidences and spatiotemporal distributions of human …

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The concept of external quality assessment super challenges with special consideration of their importance during pandemics

Christoph Buchta, Stephan W. Aberle, Stéphanie Albarède, Xavier Albe et autres

In this Personal View, we introduce the concept of external quality assessment (EQA) super challenges, in which multiple EQA providers, at approximately the same time and in a coordinated manner, use test samples with identical characteristics in their programmes. The evaluation of …

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Imported aseptic meningitis due to Toscana virus infection in Austria since 2006, including a case series from 2023

Zsófia Ilona Szojka, David M. Florian, Adriana Cabal Rosel, Werner Ruppitsch et autres

OBJECTIVES: Toscana virus (TOSV) is an emerging sandfly-borne virus, causing meningitis and encephalitis in Mediterranean and Middle Eastern regions. Only sporadic cases have been diagnosed in Austria over the past 20 years. We aim to identify and describe TOSV-associated aseptic meningitis (TOSV-AM) …

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Tick-borne encephalitis: Burden of disease and impact of vaccination, Austria (2000–2024)

Simon Raffl, David Niklas Springer, Stephan W. Aberle, David M. Florian et autres

BACKGROUND: Tick-borne encephalitis (TBE) incidence has increased across Europe in the past decade, even in Austria which has the highest vaccination coverage in Europe. This study investigated the field effectiveness of TBE vaccination using nationwide hospital-based surveillance data (2000-2024), and examined age-specific …

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Differentiation of West Nile and Usutu Virus Infections by Antibodies Directed to the Non-Structural Protein 1

Lena Roßbacher, Samuel Taschler, Elena Cecchettin, Amelie Popovitsch et autres

) comprises several important pathogens that are widespread across the globe, often co-circulating in many regions. In Austria, the closely related mosquito-borne West Nile (WN) and Usutu (USU) viruses have been detected since the early 2000s. Orthoflavivirus-neutralizing antibodies primarily target the major …

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Detection of H5N1 clade 2.3.4.4b in external quality assessment programmes: a pandemic preparedness initiative

Martin Kammel, Christoph Buchta, Stephan W. Aberle, S. W. Annie Bligh et autres

Recent outbreaks of avian influenza H5N1 infections have caused ripples of pandemic preparedness activities but no truly noticeable waves yet.1,2 An important part of pandemic preparedness is the ability for a fast provision of an appropriate testing infrastructure that delivers reliable test …

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Accurate quantification using the new RoboGene HDV RNA Quantification Kit 3.0: A European multicenter study

Evelyn Stelzl, Annemarie Berger, Sandra Ciesek, Antonella Olivero et autres

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WED-309-YI Response-guided interferon add-on to bulevirtide treatment: updated real-world insights from the austrian hepatitis D cohort study

Michael Schwarz, Caroline Schwarz, Marlene Panzer, Nikolaus Pfisterer et autres

Österreichisches Hepatitis D Register HEPAS – Therapie mit Bulevirtid: Ansprechraten, Add-on Interferon-Therapie, Therapiebeendigung

Martin Schwarz, M Hintersteininger, Christoph Schwarz, Marlene Panzer et autres

Einleitung Die chronische Hepatitis D (CHD) verursacht ein rasches Fortschreiten zur Leberzirrhose (advanced chronic liver disease, ACLD). Bulevirtid (BLV) ist die einzige zugelassene Therapie für CHD, jedoch fehlen Daten zu Therapiedauer, -eskalation und -beendigung. Material und Methodik Patient:innen wurden zum Therapiebeginn mit …

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Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19

Felix Röttele, Andreas Zollner, Carolin Mogler, Muhammed Yüksel et autres

Background A rise in paediatric cases of acute hepatitis of unknown origin (AHUO) was observed in 2022, some requiring liver transplantation. A link to adeno-associated virus 2 infection and CD4 + T-cell mediated disease was reported in cohorts in the UK and …

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Enhanced and long-lasting SARS-CoV-2 immune memory in individuals with common cold coronavirus cross-reactive T cell immunity

David M. Florian, Michael Bauer, Amelie Popovitsch, Ingrid Faé et autres

With the continuous emergence of novel SARS-CoV-2 variants, long-lasting and broadly reactive cellular and humoral immunity is critical for durable protection from COVID-19. We investigated SARS-CoV-2-specific T cell immunity in relation to antibodies, infection outcome and disease severity and assessed its durability …

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