Ju-Young Moon

Rationale and design of a nationwide prospective cohort study in type 2 diabetic kidney disease: the Korean Diabetic Kidney Disease (K-DKD) Cohort

Jin Joo, Dae Ryong, Yaeni Kim, Cheol Whee Park et autres

Background: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) worldwide. In South Korea, DKD accounts for nearly half of all ESKD cases, yet prospective data reflecting the clinical characteristics of Korean patients remain limited. This study aims …

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A position statement and recommendations for sustainable kidney care

J. -M. Yang, So Mi Kim, Eunjeong Kang, Harin Rhee et autres

The Korean Society of Nephrology has embraced the principle of "Green Nephrology" and launched campaigns addressing environmental sustainability in kidney care. These include initiatives to monitor resource usage, reduce waste generation in treatment facilities, and minimize dialysis-related environmental effects. The Society aims …

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Povetacicept for IgA Nephropathy and Primary Membranous Nephropathy

Arvind Madan, Rajesh Yalavarthy, Dong Ki Kim, Ju-Young Moon et autres

Introduction: Povetacicept is an inhibitor of B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL), 2 cytokines central to the pathogenesis of autoimmune glomerulonephritis. Both BAFF and APRIL promote B-cell and plasma cell survival and function. APRIL primarily supports plasma cell survival …

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Impact of Annual Dry Weight Changes on Mortality and Cardiovascular Outcomes in Patients Undergoing Haemodialysis

Yoosun Joo, Jihoon Park, Yang‐Gyun Kim, Sangho Lee et autres

BACKGROUND: While obesity confers a survival advantage, weight loss adversely affects the survival of patients undergoing haemodialysis. However, given the limited information regarding its long-term effects on mortality and cardiovascular events, the health benefits of weight gain remain uncertain, particularly in Asian …

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#2272 HNF4a drives metabolic reprogramming in podocytes through ChREBP/SREBP-mediated pathway and promotes cell cycle progression

Hyun Ji Lim, Yoosun Joo, Ha-Na Choi, Tae Hoon Lee et autres

Abstract Background and Aims Metabolic adaptation of podocytes plays an important role in diabetic kidney disease (DKD) progression. Recent studies have highlighted the importance of metabolic regulation in maintaining podocyte function under diabetic stress conditions. While hepatocyte nuclear factor 4 alpha (HNF4α) …

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Role of HNF4α Isoforms in Diabetic Kidney Disease Pathogenesis

Hyun Ji Lim, Tae Hoon Lee, Young Soo Moon, Yoosun Joo et autres

Background: HNF4α is a transcription factor belonging to the nuclear receptor superfamily, playing a crucial role in gene regulation and various cellular processes. In the kidney, HNF4α is essential for the development of renal proximal tubules. This factor has multiple transcript variants …

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Efficacy and Safety of Povetacicept in Patients with IgAN and Primary Membranous Nephropathy (pMN) at 48 Weeks of Treatment: The RUBY-3 Study

James A. Tumlin, Rajesh Yalavarthy, Dong Ki Kim, Ju-Young Moon et autres

Background: BAFF and APRIL are central to the pathogenesis of autoimmune glomerulonephritis (GN) by promoting B cell and plasma cell survival, which produce Gd-IgA1 and anti-Gd-IgA1 autoantibodies. APRIL is primarily limited to promoting plasma cell survival and activity, while BAFF also regulates …

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Urinary mRNA biomarkers for the noninvasive diagnosis of calcineurin inhibitor toxicity in kidney transplant recipients with graft dysfunction: a retrospective study

Jihyun Baek, Jung Woo Seo, Hyeon Seok Hwang, So‐Young Lee et autres

Background: Calcineurin inhibitor (CNI) toxicity is a significant cause of graft dysfunction in kidney transplant recipients, yet distinguishing it from acute rejection (AR) and acute tubular necrosis (ATN) remains challenging. This study investigated the use of urinary mRNA biomarkers as a noninvasive …

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Breaking the Mold: A Case of Cystic Fibrosis Beyond Sweat Chloride

Ju-Young Moon, Sophie Chalmers

Abstract Introduction: Cystic Fibrosis (CF) is traditionally diagnosed through elevated sweat chloride levels followed by genetic testing. However, depending on types of specific CFTR gene mutations, sweat chloride test may not always be conclusive. This case study presents a unique instance of …

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Proteomics

Young‐Chul Lee, Ju-Young Moon

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Urinary sediment mRNA as a potent biomarker of IgA nephropathy

Jin Sug Kim, Geon Woo Kim, Hyeon Seok Hwang, Yang‐Gyun Kim et autres

BACKGROUND: The quantification of mRNA expression in urinary sediments is a reliable biomarker for various diseases. However, few studies have investigated the clinical relevance of urinary mRNA levels in IgA nephropathy (IgAN). Thus, we investigated the expression of urinary mRNAs and their …

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Liquid Chromatography Tandem Mass Spectrometry Analysis of Lipidomic Differences between Renal Cortex and Medulla in db/db Mice

Hyun Ji Lim, Tae Hoon Lee, Yoosun Joo, Su Woong Jung et autres

Background: Lipids play crucial roles in various biological processes and are involved in the development and progression of many diseases, including diabetes. The lipid compositions in the renal cortex and medulla are different, each performing distinct functions in maintaining body homeostasis. Increased …

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