Shipra Mehta

Advanced quantitative mapping of Alzheimer’s disease neuropathology and microglial activation in post-mortem hippocampal tissue

Terri‐Leigh Stephen, Laura Korobkova, Kenneth Nguyen, Shipra Mehta et autres

Abstract We developed a high-throughput imaging workflow to spatially map Alzheimer’s disease (AD) pathology in postmortem hippocampal and medial temporal lobe sections from 65 University of Southern California Alzheimer's Disease Research Center (USC ADRC) cases classified by low, intermediate and high levels …

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Laminar organization of pyramidal neuron cell types defines distinct CA1 hippocampal subregions

Maricarmen Pachicano, Shipra Mehta, A Huete Hurtado, Tyler D. Ard et autres

Investigating the cell type organization of hippocampal CA1 is essential for understanding its role in memory and cognition and its susceptibility to neurological disorders like Alzheimer’s disease and epilepsy. Multiple studies have identified different organizational principles for gene expression and how it …

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Contouring Analysis on Synthetic Contrast-Enhanced MR from GRMM-GAN and Implications on MR-Guide Radiation Therapy

Chi Jiao, Diane C. Ling, S.X. Bian, April Keiko Vassantachart et autres

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Incidence and Dosimetric Parameters of Brainstem Toxicity in Pediatric Patients after Photon Irradiation for Posterior Fossa Tumors

Shipra Mehta, K.X. Liu, A. Vassantachart, B. Tamrazi et autres

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Finding nuclear localization signals: A quantitative analysis

Shipra Mehta

Prediction of Protein Function Using Protein–Protein Interaction Data

Minghua Deng, Kui Zhang, Shipra Mehta, Ting Chen et autres

Assigning functions to novel proteins is one of the most important problems in the postgenomic era. Several approaches have been applied to this problem, including the analysis of gene expression patterns, phylogenetic profiles, protein fusions, and protein-protein interactions. In this paper, we …

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Prediction of protein function using protein-protein interaction data

Minghua Deng, Kui Zhang, Shipra Mehta, Ting Chen et autres

Assigning functions to novel proteins is one of the most important problems in the post-genomic era. Several approaches have been applied to this problem, including analyzing gene expression patterns, phylogenetic profiles, protein fusions and protein-protein interactions. We develop a novel approach that …

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Inferring Domain–Domain Interactions From Protein–Protein Interactions

Minghua Deng, Shipra Mehta, Fengzhu Sun, Ting Chen

The interaction between proteins is one of the most important features of protein functions. Behind protein-protein interactions there are protein domains interacting physically with one another to perform the necessary functions. Therefore, understanding protein interactions at the domain level gives a global …

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Inferring domain-domain interactions from protein-protein interactions

Minghua Deng, Shipra Mehta, Fengzhu Sun, Ting Chen

Protein-protein interactions are important events in cellular and biochemical processes within a cell. Several researchers have undertaken the task of analyzing protein-protein interactions covering all genes of an organism by using yeast two-hybrid assays. Protein-protein interactions involve physical interactions between protein domains. …

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