Haoran Tang

STR-PG: A Topology-decoupled Pangenome Framework for Scalable Short-read Genotyping of Short Tandem Repeats

Jiajing Yuan, Zhengfa Xue, Haoran Tang, YUQIAN LIU et autres

Abstract Short tandem repeats (STRs) are a rich and highly polymorphic source of human genetic variation, but representing and genotyping them in pangenome graphs remains challenging. Explicitly encoding each STR allele as a separate graph path results in increasingly complex local structures …

cn (code pays fourni par la source)

Generative AI-Assisted Discovery of HPK1 Inhibitors

Kathryn A. Giblin, Kun Song, Hongming Chen, Weijie Chen et autres

Generative artificial intelligence (AI) is now widely applied in medicinal chemistry, with detailed case studies emerging in the literature. Here, we describe an early application of REINVENT, AstraZeneca's in-house generative molecular design platform, to identify new inhibitor scaffolds for hematopoietic progenitor kinase …

gb, us, au (code pays fourni par la source)

Automatic generation of labanotation based on a hybrid transformer–LSTM network with multi-scale spatio-temporal features

Huan Zhang, Yan Li, Kai Fan, Tianqi Xu et autres

To support the digital preservation and dissemination of folk dance as an intangible cultural heritage, the automatic generation of Labanotation from motion capture data has become a prominent research direction. However, existing techniques show limited capability in extracting skeletal features and fail …

cn (code pays fourni par la source)

Engineering of multiple modules to enhance lignocellulose degradation ability in Bacillus subtilis using CRISPR/Cas9 system

Zhiwei Wang, Gongwei Liu, Zhizhong Meng, Jie Xu et autres

Bacillus subtilis is widely employed for lignocellulose degradation. However, wild-type strains typically exhibit low and incomplete cellulase activities. This study aimed to engineer recombinant B. subtilis strains harboring complete, high-efficiency cellulase systems using CRISPR/Cas9-mediated genome editing. After optimization of signal peptides, transcriptional …

cn (code pays fourni par la source)

Seeing through Imagination: Learning Scene Geometry via Implicit Spatial World Modeling

Meng Cao, Haokun Lin, Haijiang Li, Haoran Tang et autres

Spatial reasoning, the ability to understand and interpret the 3D structure of the world, is a critical yet underdeveloped capability in Multimodal Large Language Models (MLLMs). Current methods predominantly rely on verbal descriptive tuning, which suffers from visual illiteracy, i.e., they learn …

Video Spatial Reasoning with Object-Centric 3D Rollout

Haoran Tang, Meng Cao, Ruyang Liu, Xiaoxi Liang et autres

Recent advances in Multi-modal Large Language Models (MLLMs) have showcased remarkable capabilities in vision-language understanding. However, enabling robust video spatial reasoning-the ability to comprehend object locations, orientations, and inter-object relationships in dynamic 3D scenes-remains a key unsolved challenge. Existing approaches primarily rely …

Hypoglycemia Beliefs, Impaired Hypoglycemia Awareness, and Severe Hypoglycemia in Insulin-Treated Type 2 Diabetes: Insights from CGM Users

Yu Kuei Lin, Haoran Tang, Wen Ye, Alexandria Ratzki‐Leewing et autres

Recent data indicate that severe hypoglycemia (SH) persists in individuals with insulin-treated type 2 diabetes, despite using continuous glucose monitoring (CGM)(1). While traditional SH risk factors, such as impaired awareness of hypoglycemia (IAH), are well-studied in non-CGM users(2), their relevance to type …

Hypoglycemia Beliefs, Impaired Hypoglycemia Awareness, and Severe Hypoglycemia in Insulin-Treated Type 2 Diabetes: Insights From CGM Users

Yu Kuei Lin, Haoran Tang, Wen Ye, Alexandria Ratzki‐Leewing et autres

us, gb (code pays fourni par la source)

Hypoglycemia Beliefs, Impaired Hypoglycemia Awareness, and Severe Hypoglycemia in Insulin-Treated Type 2 Diabetes: Insights from CGM Users

Yu Kuei Lin, Haoran Tang, Wen Ye, Alexandria Ratzki‐Leewing et autres

Recent data indicate that severe hypoglycemia (SH) persists in individuals with insulin-treated type 2 diabetes, despite using continuous glucose monitoring (CGM)(1). While traditional SH risk factors, such as impaired awareness of hypoglycemia (IAH), are well-studied in non-CGM users(2), their relevance to type …

A Personalized 3D-Printed Smart Splint with Integrated Sensors and IoT-Based Control: A Proof-of-Concept Study for Distal Radius Fracture Management

Yufeng Ma, Haoran Tang, Baojian Wang, Xiliang Liu

Conventional static fixation for distal radius fractures (DRF) is clinically challenging, with methods often leading to complications such as malunion and pressure-related injuries. These issues stem from uncontrolled pressure and a lack of real-time biomechanical feedback, resulting in suboptimal functional recovery. To …

cn (code pays fourni par la source)

Disitamab vedotin combined with toripalimab and radiotherapy for multimodal organ-sparing treatment of muscle invasive bladder cancer: a proof-of-concept study

Lu Zhang, Di Jin, Jingyu Zang, Qian Lei et autres

PURPOSE: Although trimodal therapy is currently the standard organ-sparing approach for muscle-invasive bladder cancer (MIBC), its clinical benefit is limited, and noninvasive biomarkers to guide dynamic decision-making are lacking. Here, we present a proof-of-concept study evaluating disitamab vedotin (RC48, a HER2-targeted antibody-drug …

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Abstract 5888: Urinary ctDNA tumor fraction monitoring enhances non-invasive assessment of molecular response in bladder-preserving treatment of muscle-invasive bladder cancer

Jing Ti Deng, Feng Wen, Haoran Tang, Cancan Jia et autres

Introduction: While radical cystectomy (RC) following neoadjuvant therapy remains the standard of care for muscle-invasive bladder cancer (MIBC), bladder-preserving treatments offer a viable option for selected patients to improve quality of life. Rapid detection of therapeutic response is critical for clinical decision-making …

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