Ying Jie Zhu

Myelin-Inspired 3D PEGylation of Framework Nucleic Acids Enables Simultaneous Long Circulation and Rapid Renal Clearance

Qian Chen, Fei Ding, Shuangye Zhang, Xuefei Hu et autres

The rational design of nanomedicines is fundamentally constrained by a physicochemical paradox at the bio-nano interface: strategies to prolong circulation inevitably suppress clearance, often resulting in long-term accumulation and systemic toxicity. To address this, we propose spatial conformation engineering as an additional …

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Innate Immunity of Framework Nucleic Acids

Linjie Guo, Fei Zhou, Ying Jie Zhu, Jiang Li et autres

ConspectusNucleic acid nanotechnology has fundamentally transcended the classic paradigm of DNA and RNA as passive carriers of genetic blueprints, which enables the rational design and construction of precise nanostructures with defined shapes, dynamics, and functions. This programmability has revolutionized approaches in biomedicine, …

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NEMF inhibits the proliferation and migration of ovarian cancer cells by blocking the PI3K/mTOR pathway

Ying Jie Zhu, Yi lin Zhang, Chuang Chen, Jing Fan

Abstract Nuclear export mediator factor (NEMF) is considered to be a tumor suppressor in Drosophila. Based on the analysis of data from an online database, NEMF is downregulated in ovarian cancer. However, the mechanism underlying its expression has not been reported thus …

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The impact of methylprednisolone and rituximab on podocyte injury caused by puromycin aminonucleoside

Li Wang, Manman Zhao, Jialiang Zhu, Ran Hua et autres

Introduction: To explore how MP and RTX impact TRPC6's expression and localization, and assess MP's and RTX's effects on podocyte injury and recovery. Methods: MPC5 cells were simultaneously grown alongside a control group and under various conditions: exposure to puromycin aminonucleoside (PAN) …

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Magnetically Driven High-Speed Rolling Nanoclusters for Enhanced CRISPR/Cas9 Genome Editing

Huating Kong, Xia Liu, Kai Xia, Yong Guan et autres

Despite the tremendous potential of the CRISPR/Cas9 gene-editing technology in precision therapeutics, intracellular delivery remains a major challenge. High cytoplasmic viscosity and lysosomal entrapment significantly impair the cytosolic transport and gene-editing efficiency. In this study, we demonstrate that both the size and …

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Comprehensive regulation of γ-globin expression by epigenetic modifications and protein post-translational modifications

Dahang Ye, Meihuan Chen, Ying Jie Zhu, Liangpu Xu et autres

As a member of the hemoglobin family, γ-globin is usually persistently expressed at high levels to perform the oxygen-carrying function during fetal development. In recent years, related gene editing clinical trials have confirmed that reactivation of γ-globin expression is a promising therapeutic …

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The crosstalk of m6A modification and non-coding RNAs in ferroptosis regulation in human diseases

Ying Jie Zhu, Meihuan Chen, Xin Feng, Dahang Ye et autres

In recent years, N6-methyladenosine (m6A) modification has stood out as a key epitranscriptional mechanism. It governs nearly all stages of RNA metabolism-from RNA processing and nuclear export to translation and degradation. Non-coding RNAs (ncRNAs)-a broad category that includes microRNAs (miRNAs), long non-coding …

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High-pressure Golgi-Cox neuronal staining for X-ray whole-brain imaging

Qiaowei Tang, Xiaoqing Cai, Yu Liu, Yu Zhang et autres

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Engineering Highly Luminescent and Chiral Metal Nanoclusters with Single-Stranded DNA

Bingjie Yan, Mulin Duan, Bijia Chen, Haoran Zheng et autres

The photoluminescent properties of atomically precise metal nanoclusters (MCs) have attracted intense interest in bioimaging and optical device applications, which are restricted by the limited brightness of MCs. In this study, we developed a single stranded (ss-) DNA-based ligand engineering approach to …

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Author response for "A clickable spherical nucleic acid probe for fluorescence and synchrotron radiation X-ray dual-modality imaging"

Xiaobo Wang, Xin Yan, Feng Zhou, Qiaowei Tang et autres

High‐Resolution Single‐Neuron Reconstruction Analysis in Golgi‐Stained Brain Tissues

Qiaowei Tang, Xiaoqing Cai, Zhiming Shen, Jichao Zhang et autres

Understanding the structural and functional organisation of brain networks is a fundamental objective in neuroscience, with three-dimensional (3D) reconstruction of single-neuron morphology serving as a critical foundation. The Golgi staining method, which enables random neuronal labeling and provides high-contrast signals in both …

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Author response for "A clickable spherical nucleic acid probe for fluorescence and synchrotron radiation X-ray dual-modality imaging"

Xiaobo Wang, Xin Yan, Feng Zhou, Qiaowei Tang et autres