Wen Lu

Inter‐institutional perspectives on usage of fibrinogen replacement therapies in North America

Cindy Tay, Laura D. Stephens, Wen Lu, Kerry O'Brien et autres

BACKGROUND AND OBJECTIVES: Cryoprecipitated antihemophilic factor (cryoprecipitate), fibrinogen concentrate (FC), and pathogen-reduced cryoprecipitated fibrinogen complex (PR cryoprecipitate) are sources of fibrinogen replacement, and each has advantages and disadvantages in terms of cost, efficacy, safety, and logistics of administration. This study examines the …

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Transfusion thresholds in apheresis: Results from a survey and focus group discussion

Kyle Annen, Jay S. Raval, Gaurav K. Gupta, Monika Paroder et autres

BACKGROUND: Clinical practice guidelines for red blood cell (RBC) or platelet transfusion are not tailored specifically for therapeutic apheresis patients. It is unclear how provider transfusion thresholds in the peri-therapeutic apheresis period correlate with guidelines. We hypothesized that individual apheresis clinician practice …

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Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome

Richard M. Kaufman, Anne G. Hoen, Jenna Khan, C. Michael Knudson et autres

Importance: Recent case reports suggest that B antigen-containing blood products may be associated with anaphylactic transfusion reactions in recipients with preformed immunoglobulin E to galactose-α-1,3-galactose (alpha-gal). Objective: To test the association of local alpha-gal syndrome (AGS) prevalence and allergic transfusion reaction (ATR) …

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An Annual Review of Important Apheresis Articles in 2025 From the American Society for Apheresis Attending Physician Subcommittee

Wen Lu, Laura Dilly, Marisa C. Saint Martin, Nicole D. Zantek et autres

Apheresis medicine is a continually evolving field with numerous studies published each year. To help apheresis practitioners stay up to date with the current literature, members of the American Society for Apheresis (ASFA) Attending Physician Subcommittee identified and summarized 10 seminal articles …

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Variation in Chronic Automated Red Cell Exchange Practices for Sickle Cell Disease: Insights Into Isovolemic Hemodilution Use

Jennifer M. Jones, Fatima Aldarweesh, Nicole Aqui, Aleh Bobr et autres

Prior surveys of chronic automated red blood cell exchange (RCE) for patients with sickle cell disease (SCD) have identified considerable procedural variability, especially with the use of isovolemic hemodilution red blood cell exchange (IHD-RCE). We conducted a survey of chronic RCE practices …

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Red cell antibody and antigen patterns in patients with sickle cell disease: A multi‐center analysis

Mischa L. Covington, Elizabeth S. Allen, Stella T. Chou, Stephanie Conrad et autres

BACKGROUND: Red cell alloimmunization complicates sickle cell disease (SCD) management despite current widespread prophylactic Rh/K matching in the United States (US). Regional antibody patterns remain poorly characterized. STUDY DESIGN AND METHODS: We conducted a retrospective analysis of 2965 SCD patients from 9 …

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Clinical significance of anti‐M in pregnancy and self‐reported ancestry: The BEST collaborative study

Wen Lu, Alyssa Ziman, Charles Yin, M. T. S. Yan et autres

BACKGROUND: Anti-M antibodies were described as rarely eliciting hemolytic disease of the fetus and newborn (HDFN) in pregnancy. More recent literature, primarily from Asia, reports severe HDFN attributed to maternal anti-M. The objective of this study is to determine if there is …

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An Annual Review of Important Apheresis Articles in 2024 From the American Society for Apheresis Attending Physician Subcommittee

Wen Lu, Victoria Costa, Ding Wen Wu, Mohamed Alsammak et autres

The American Society for Apheresis (ASFA) Attending Physician Subcommittee of the Physicians' Committee performed an annual review of articles published in 2024 related to apheresis medicine. The 10 seminal apheresis articles selected by the subcommittee members are summarized in this review. PubMed …

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A survey on the use of Rh immune globulin during a nationwide shortage

Kerry L. O’Brien, Elizabeth Abels, Sara Bakhtary, Melissa R. George et autres

BACKGROUND: Rh immune globulin (RhIG) is used to prevent D alloimmunization and reduce the risk of hemolytic disease of the fetus and newborn (HDFN). Its use has been expanded to include immunoprophylaxis after D-incompatible transfusions. In the United States, a protracted RhIG …

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Survey of cryoprecipitate production and cryoprecipitate and fibrinogen concentrate utilization in North America: Variable practices observed from July 2016 to June 2021, The BEST Collaborative Study

Wen Lu, Umesh Singh, Alyssa Ziman, Ralph R. Vassallo et autres

BACKGROUND: Cryoprecipitated antihemophiliac factor (cryo) is primarily used to replenish fibrinogen in acquired coagulopathy. Little has been reported about its usage patterns within hospitals with respect to patient population, frequency of use, and dosing. STUDY DESIGN AND METHODS: Cryo production and usage …

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Serologic Characteristics and Clinical Significance of Non-ABO Red Blood Cell Antibodies in Hematopoietic Stem Cell Transplantation: The BEST Collaborative Study

Valery J. Kogler, Monica B. Pagano, Magali J. Fontaine, Vahid Azimi et autres

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Quality indicators for cell collections for immune effector cell and gene therapy: recommendations from the American Society for Apheresis

Nicole A. Aqui, Patricia A. Shi, Yara A. Park, Yvette C. Tanhehco et autres

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