Accès ouvert
2026
article
OpenAlex
Janghyun Yoo, Raghav Karthikeyan, Kashi Kamat, Christopher Chan et autres
Ductal carcinoma in situ (DCIS) spans a biologic continuum from atypical ductal hyperplasia (ADH) to high-grade lesions with variable risk of progression to invasive ductal carcinoma (IDC), yet morphologic assessment by hematoxylin and eosin (H&E) remains diagnostically limited, particularly at the benign …
kr, Éthiopie, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Janghyun Yoo, Raghav Karthikeyan, Kashi Kamat, Christopher Chan et autres
Abstract Ductal carcinoma in situ (DCIS) spans a biologic continuum from atypical ductal hyperplasia (ADH) to high-grade lesions with variable risk of progression to invasive ductal carcinoma (IDC), yet morphologic assessment by hematoxylin and eosin (H&E) remains diagnostically limited, particularly at the …
kr, Éthiopie, us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Christopher Chan, Elham Arbzadeh, Shabnam Samankan, Patricia S. Latham et autres
Abstract Purpose Ductal carcinoma in situ (DCIS) is a non-invasive breast neoplasm frequently overtreated because biomarkers of invasive progression are lacking. We previously identified a pro-invasive mechanotransduction pathway in which ductal cell crowding inactivates plasma-membrane (PM) transient receptor potential vanilloid 4 (TRPV4), …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Shuyan Zhou, Yi Zhang, Zongzhu Li, Zhuqing Li et autres
The nucleotide excision repair (NER) pathway is the primary mechanism for removing UVB-induced photoproducts in mammals. While early steps of NER are well defined, the later step of gap-filling DNA synthesis remains incompletely understood. Here, we report And-1, a DNA replication and …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xiyan Xiang, Kirti Shetty, Herbert Yu, Bibhuti Nath Mishra et autres
BACKGROUND: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths, primarily due to late-stage diagnosis. In this multicenter study, our goal is to identify functional biomarkers that stratify the risk of HCC in patients with cirrhosis (CP) for early diagnosis. …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xiangning Bu, Nathanael Ashby, Teresa Vitali, Sulgi Lee et autres
Cell crowding is a common microenvironmental factor influencing various disease processes, but its role in promoting cell invasiveness remains unclear. This study investigates the biomechanical changes induced by cell crowding, focusing on pro-invasive cell volume reduction in ductal carcinoma in situ (DCIS). …
us
(code pays fourni par la source)
Accès ouvert
2025
peer-review
OpenAlex
Xiangning Bu, Nathanael Ashby, Teresa Vitali, Sulgi Lee et autres
Cell crowding drives a pro-invasive mechanotransduction pathway in high-grade DCIS, inducing TRPV4 inhibition, calcium and cell volume reduction, and increased invasion, with compensatory plasma-membrane TRPV4 relocation indicating pathway activation.
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Xiangning Bu, Nathanael Ashby, Teresa Vitali, Sulgi Lee et autres
Cell crowding is a common microenvironmental factor influencing disease progression, yet its role in promoting cell invasiveness remains poorly understood. Here, we demonstrate that cell crowding enhances the invasiveness of high-grade ductal carcinoma in situ (DCIS) cells through pro-invasive cell volume reduction. …
us
(code pays fourni par la source)
Accès ouvert
2025
peer-review
OpenAlex
Xiangning Bu, Nathanael Ashby, Teresa Vitali, Sulgi Lee et autres
Cell crowding is a common microenvironmental factor influencing various disease processes, but its role in promoting cell invasiveness remains unclear. This study investigates the biomechanical changes induced by cell crowding, focusing on pro-invasive cell volume reduction in ductal carcinoma in situ (DCIS). …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Xiangning Bu, Nathanael Ashby, Teresa Vitali, Sulgi Lee et autres
Abstract Cell crowding is a common microenvironmental factor influencing various disease processes, but its role in promoting cell invasiveness remains unclear. This study investigates the biomechanical changes induced by cell crowding, focusing on pro-invasive cell volume reduction in ductal carcinoma in situ …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
María José Caballero-Herrero, Celia Arias-Sánchez, Ignacio Quevedo, Patricia S. Latham et autres
Abstract Diabetic nephropathy is the most important cause of renal failure worldwide and is characterized by sustained inflammation regulated in part by NLRP3 Inflammasome. Attenuation of inflammation is a major priority to prevent renal damage. Our previous publications show that DJ-1 has …
es, us, cn, ar, bg
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Xiangning Bu, Nathanael Ashby, Teresa Vitali, Sulgi Lee et autres
Abstract Cell crowding is a common microenvironmental factor that affects various disease processes, but its impact on cell invasiveness into surrounding tissues is not well understood. This study investigates the biomechanical changes induced by cell crowding, focusing on pro-invasive cell volume reduction …
us
(code pays fourni par la source)