Cheng-Lin Tsai

Identification of novel genetic biomarkers for ChAdOx1 nCoV-19 mediated immunogenicity

Wan‐Hsuan Chou, Che‐Mai Chang, Jafit Ting, Min‐Rou Lin et autres

Background Research comprehensively examining factors for COVID-19 DNA vaccine responses is lacking, particularly in Asian populations. This study aims to investigate biomarkers of reactogenic and immunogenic responses after DNA-based COVID-19 vaccination in a Taiwanese population. Methods A genome-wide association study (GWAS) of …

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Exploring the genomic and transcriptomic profiles of glycemic traits and drug repurposing

Min‐Rou Lin, Cheng-Lin Tsai, Cai-Sian Liao, Chun-Yu Wei et autres

BACKGROUND: Type 2 diabetes is an increasingly prevalent metabolic disorder with moderate to high heritability. Glycemic indices are crucial for diagnosing and monitoring the disease. Previous genome-wide association study (GWAS) have identified several risk loci associated with type 2 diabetes, but data …

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Using Genome-wide Association Study to Identify Genetic Variants for Blood Sugar Regulation and Glucose Metabolism Rare Diseases in a Taiwan population

蔡承霖, Cheng-Lin Tsai

碩士

Reduction of NF-κB Signals in Platelets and Prolongation of Platelet Plug Formation against High Shear Flow in Whole Blood on Human Subject by Columbianadin

Chih‐Wei Hsia, Chih‐Hao Yang, Joen‐Rong Sheu, Chih‐Hsuan Hsia et autres

Myocardial infarction and cerebral ischemic stroke during the process of arterial thrombosis are prominently causes of death worldwide. Platelets are anucleated cells and play a critical factor in these diseases. Columbianadin (CBN), a coumarin derivative from plants, inhibits effective platelet activation. In …

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Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin αIIbβ3 inside-out but not outside-in signals

Shaw-Min Hou, Chih‐Wei Hsia, Cheng-Lin Tsai, Chih-Hsuan Hsia et autres

Abstract Background Columbianadin (CBN) is one of the main coumarin constituents isolated from Angelica pubescens. The pharmacological value of CBN is well demonstrated, especially in the prevention of several cancers and analgesic activity. A striking therapeutic target for arterial thrombosis is inhibition …

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Suppression of Human Platelet Activation via Integrin αIIbβ3 Outside-In Independent Signal and Reduction of the Mortality in Pulmonary Thrombosis by Auraptene

Chih‐Wei Hsia, Cheng-Lin Tsai, Joen‐Rong Sheu, Wan‐Jung Lu et autres

Auraptene is the most abundant coumarin derivative from plants. The pharmacological value of this compound has been well demonstrated, especially in the prevention of cancer and neurodegenerative diseases. Platelet activation is a major factor contributing to arterial thrombosis. Thus, this study evaluated …

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Inhibitory mechanisms of columbianadin and auraptene in human platelet

蔡承霖, Cheng-Lin Tsai

碩士 指導教授：許準榕 共同指導教授：呂婉榕 委員：顏茂雄 委員：黃德富 委員：謝政穎

Novel Therapeutic Agent against Platelet Activation In Vitro and Arterial Thrombosis In Vivo by Morin Hydrate

Chih‐Wei Hsia, Ming-Ping Wu, Marappan Velusamy, Chih‐Hsuan Hsia et autres

Morin hydrate, a bioactive flavonoid, has been proven to prevent inflammation and apoptosis of cells. Flavonoids can reduce the risk of cardiovascular diseases, in which platelet activation plays a major role. This study investigated the effect of morin hydrate on platelet activation …

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Short-term Panax Ginseng And Salvia Miltiorrhiza Supplementation On Pulse Wave Velocity And Dehydroepiandrosterone After Downhill Running Exercise

Hsin-Fu Lin, Kang Tung, Cheng-Lin Tsai, Ho-Seng Wang et autres

The Effect of Whole Body Vibration Stimulus using Varying Oscillation Amplitudes on Lower Body Power

Cheng-Lin Tsai, Jung‐Charng Lin

PURPOSE: To compare the impact on performance from vibration stimulations to the lower body using different oscillation amplitudes (0.5mm, 1mm, 1.5mm, 2mm) under the same frequency (20Hz). METHODS: The subject consisted of 15 healthy males, aged 24.80±4.19 years with height 174.20±5.77 cm …

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Severe Hypothyroidism Masquerading As Renal Impairment

Chia-Shan Liu, Tsai‐Kun Wu, Ying-Lan Yu, Shiaw-Wen Chien et autres

Although subclinical primary hypothyroidism was common in patients with chronic kidney disease, renal impairment resulting from hypothyroidism was a rare occurrence. We described a 33-year-old young man who presented with rapid deterioration of renal function. He stated a two-week history of sudden …