Analysis of gene expression changes upon topobexin treatment and TOP2B-knockout in hiPSC-derived cardiomyocytes
Veronika Keresteš, Ian G. Cowell, Anna Jirkovská, Mushtaq M. Khazeem et autres
0 citationsBiology Open
Anna Jirkovská
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29Publications signalées
401Citations signalées
3Affiliations récentes
Institutions déclarées
Domaines associés
Chemotherapy-induced cardiotoxicity and mitigationCancer therapeutics and mechanismsTrace Elements in HealthCancer Treatment and PharmacologyIron Metabolism and Disorders
Publications récentes
Analysis of Gene Expression Changes upon Topobexin Treatment and TOP2B-knockout in hiPSC derived cardiomyocytes
Veronika Keresteš, Ian G. Cowell, Anna Jirkovská, Mushtaq M. Khazeem et autres
0 citationsbioRxiv (Cold Spring Harbor Laboratory)
Topobexin Targets a Unique Druggable Pocket of Topoisomerase II for Beta Isoform- Selective Control of DNA Damage During Anthracycline Chemotherapy
Jan Kubeš, Galina Karabanovich, Anh Cong, Iuliia Melnikova et autres
0 citationsStructural Dynamics
Daunorubicin and its hydroxy metabolite in cardiomyocytes: insights into cellular kinetics, toxicity, DNA damage, and dexrazoxane-induced cardioprotection
Lenka Applová, Paulína Dudášová-Hatoková, Jan Kubeš, Nela Váňová et autres
1 citationArchives of Toxicology
Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection
Jan Kubeš, Galina Karabanovich, Anh Cong, Iuliia Melnikova et autres
15 citationsNature Communications
Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage
Veronika Keresteš, Jan Kubeš, Lenka Applová, Petra Kollárová-Brázdová et autres
9 citationsToxicological Sciences
Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation
Eduard Jirkovský, Anna Jirkovská, Hana Bavlovič Piskáčková, Veronika Skalická et autres
62 citationsCirculation Heart Failure
Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit modelin vivo
Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská et autres
12 citationsClinical Science
Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions
Anna Jirkovská, Galina Karabanovich, Jan Kubeš, Veronika Skalická et autres
23 citationsJournal of Medicinal Chemistry
Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity
Hana Bavlovič Piskáčková, Hana Jansová, Jan Kubeš, Galina Karabanovich et autres
8 citationsScientific Reports
Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase IIβ Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity
Petra Kollárová-Brázdová, Anna Jirkovská, Galina Karabanovich, Zuzana Pokorná et autres
20 citationsJournal of Pharmacology and Experimental Therapeutics
In vitro and in vivo investigation of cardiotoxicity associated with anticancer proteasome inhibitors and their combination with anthracycline
Zuzana Pokorná, Eduard Jirkovský, Markéta Hlaváčková, Hana Jansová et autres
15 citationsClinical Science
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