Zainub Ajmal

Exploring Large Language Models for Specialist-Level Oncology Care

Anil Palepu, Vikram Dhillon, Polly Niravath, Wei‐Hung Weng et autres

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A phase I trial of intratumoral adenovirus-interleukin-12 (IT-ADV/IL-12) and atezolizumab in metastatic non-small cell lung cancer (NSCLC) progressed on first-line immunotherapy.

Zainub Ajmal, Jian Guan, Jitesh Joshi, Eric Bernicker et autres

8551 Background: Interleukin-12 (IL-12) is a cytokine that enhances anti-tumor immunity via interferon-gamma release and has demonstrated synergistic effects with immune checkpoint inhibitors (ICIs) in immunoquiescent tumors. We report results of phase I trial of intratumoral adenovirus-interleukin-12(IT-ADV/IL-12)plus atezolizumab in metastatic NSCLC patients …

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Exploring Large Language Models for Specialist-level Oncology Care

Anil Palepu, Vikram Dhillon, Polly Niravath, Wei‐Hung Weng et autres

Large language models (LLMs) have shown remarkable progress in encoding clinical knowledge and responding to complex medical queries with appropriate clinical reasoning. However, their applicability in subspecialist or complex medical settings remains underexplored. In this work, we probe the performance of AMIE, …

Outcomes of liver transplant recipients with pretransplant malignancies: Insights from a single institution’s experience.

Nikitha Vobugari, Kirk Heyne, Ashton A. Connor, Zainub Ajmal et autres

11173 Background: Increasing liver transplantation (LT) utilization has resulted in more and more patients with a history of a non-hepatobiliary malignancy. Rather than deny such patients a lifesaving therapy the benefits must be weighed against risk of tumor recurrence and de novo …

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5-hydroxymethylcytosine in cell-free DNA as liquid biomarker for immune checkpoint inhibitor therapy in non–small cell lung cancer.

Zainub Ajmal, Jianming Shao, Randall J. Olsen, Saro Kasparian et autres

e20563 Background: Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1), and its ligand (PD-L1) are the mainstay of treatment for metastatic non-small cell lung cancer (NSCLC) in patients lacking targetable driver mutations. However, optimal predictive biomarkers are lacking. We used …

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Real-world experience on tolerability and safety of relugolix combined with androgen signaling inhibitors in patients with advanced prostate cancer.

Jian Guan, Shubham Adroja, Zainub Ajmal, Yuan Gao et autres

85 Background: Relugolix is the first oral GNRH antagonist approved by the FDA in 2021 for the treatment of advanced prostate cancer (PCa). Approval was based on HERO study, which showed a rapid and sustained testosterone suppression superior to that of Leuprolide …

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Clinical outcomes of patients with early-stage epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer who underwent reflex molecular testing.

Ryan Blair Kieser, Ethan Burns, Zimu Gong, Jian Guan et autres

e20531 Background: One-third of patients with newly diagnosed non-small cell lung cancer (NSCLC) present at an early stage. Surgical resection remains the standard of care for medically fit patients. Adjuvant chemotherapy has shown benefit in stage II and III disease, but with …

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Disparity in Breast Cancer Care: An Overlooked Subpopulation

Zainub Ajmal, Syed A. Mehdi

Journal of the American College of Surgeons ():10.1097/XCS.0000000000000760, May 15, 2023. | DOI: 10.1097/XCS.0000000000000760

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Graft-Versus-Host Disease in Allogeneic Hematopoietic Stem Cell Transplant: SARS-CoV-2 Vaccine as a Potential Trigger

Amin Azem, Zainub Ajmal, Mihir Raval

Allogeneic hematopoietic stem cell transplant (AHSCT) recipients are at a risk of developing immune-mediated tissue damage from activation of the donor's immunocompetent T cells by the recipient's normally expressed antigens, a phenomenon called graft-versus-host disease (GVHD). With the emergence of the novel …

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Leiomyosarcoma of the Penis: A Case Report and Re-Appraisal

Zainub Ajmal

Background: Penile leiomyosarcoma arises from smooth muscles, which can be from dartos fascia, erector pili in the skin covering the shaft, or from tunica media of the superficial vessels and cavernosa. We describe presentation, treatment options, and recurrence pattern of this rare …

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EBV-ASSOCIATED ATYPICAL HEMOLYTIC UREMIC SYNDROME PRESENTING WITH DIFFUSE ALVEOLAR HEMORRHAGE

Fatima Tuz Zahra, Zainub Ajmal, Sana Ghalib, Boris Shkolnik

SEVERE NONINFECTIOUS PNEUMONITIS ASSOCIATED WITH IBRUTINIB FOR DIFFUSE LARGE-B-CELL LYMPHOMA

Fatima Tuz Zahra, Zainub Ajmal, Gowthami Kobbari, Gregory F. Wu