Reed Mullen

Multicenter Retrospective Study of Stereotactic Radiosurgery for Gynecological Cancer Brain Metastases

Mathilde Djeneba Billau, Andréanne Hamel, Jean-Nicolas Tourigny, Christian Iorio‐Morin et autres

BACKGROUND AND OBJECTIVES: Gynecological cancers represent 10% to 15% of cancers in women, but brain metastases (BM) are uncommon, with limited evidence regarding their management. This study investigates the role of stereotactic radiosurgery (SRS) for BM from primary gynecological cancers. METHODS: Institutions …

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P360 Liquid biopsy to support tissue-free diagnosis and treatment of suspected advanced biliary tract cancer – an access programme case report

Lauren Jones, Justin Mencel, Reed Mullen, Terri McVeigh et autres

Introduction Biliary tract cancers (BTC) can be challenging to histologically diagnose if there are patient factors precluding biopsy or insufficient tissue for analysis. Guardant 360© liquid biopsy (LB) is CE marked for stage III and IV solid tumors; it detects ctDNA in …

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Liquid biopsies for faster diagnosis of suspected advanced pancreatic and biliary tract cancers: ACCESS, a UK innovation programme.

Lauren Jones, Justin Mencel, Reed Mullen, Sofia Sardo Infirri et autres

614 Background: Tissue diagnosis in biliary tract (BTC) and pancreatic (PC) cancer is challenging due to anatomical location and patient (pt) factors (frailty, sepsis); approximately 25% of invasive biopsies are nondiagnostic, requiring repeat procedure. Most BTC and PC pts present with advanced …

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Volumetric growth rate of incidentally found meningiomas on immunotherapy

Assaf Berger, Reed Mullen, Kenneth Bernstein, Elad Mashiach et autres

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Outcomes of Gamma Knife Radiosurgery for Brain Metastases in the Motor Cortex

Shefalika Prasad, Juan Diego Alzate, Reed Mullen, Kenneth E. Bernstein et autres

BACKGROUND AND OBJECTIVES: To study the clinical, imaging, and survival outcomes in patients with motor cortex brain metastases treated with stereotactic radiosurgery (SRS). METHODS: Imaging and clinical data were obtained from our prospective patient registry. Tumor volumes were obtained from serial imaging …

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EGFR-mutated non-small lung cancer brain metastases and radiosurgery outcomes with a focus on leptomeningeal disease

Juan Diego Alzate, Reed Mullen, Elad Mashiach, Kenneth Bernstein et autres

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Low-Dose Radiosurgery for Brain Metastases in the Era of Modern Systemic Therapy

Juan Diego Alzate, Elad Mashiach, Assaf Berger, Kenneth Bernstein et autres

BACKGROUND AND OBJECTIVES: Dose selection for brain metastases stereotactic radiosurgery (SRS) classically has been based on tumor diameter with a reduction of dose in the settings of prior brain irradiation, larger tumor volumes, and critical brain location. However, retrospective series have shown …

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Neurological Outcomes of Radiosurgery for Brain Metastases in the Motor Cortex (P10-13.001)

Shefalika Prasad, Juan Diego Alzate, Reed Mullen, Tanxia Qu et autres

Objective: To study the neurological presentation and outcomes of patients with motor cortex brain metastases treated with stereotactic radiosurgery (SRS). Background: Literature on the neuro-oncological impact of radiosurgery in eloquent brain regions with regards to safety, efficacy, and survival is limited. Design/Methods: …

876 Significant Survival Improvements for Patients with Melanoma Brain Metastases: Can We Reach Cure in the Current Era?

Assaf Berger, Kenneth E. Bernstein, Juan AlzateRamirez, Reed Mullen et autres

INTRODUCTION: New therapies for melanoma have been associated with increasing survival expectations, as opposed to the dismal outcomes of only a decade ago. METHODS: We reviewed 171 melanoma patients with BM receiving stereotactic radiosurgery (SRS) who were followed with point-of-care data collection …

509 Modern Hearing Preservation Outcomes After Vestibular Schwannoma Stereotactic Radiosurgery

Assaf Berger, Juan AlzateRamirez, Kenneth E. Bernstein, Reed Mullen et autres

INTRODUCTION: For patients with vestibular schwannoma (VS), stereotactic radiosurgery (SRS) has proven effective in controlling tumor growth, while hearing preservation remains a key goal. METHODS: During the years 2013-2018, 353 patients underwent Gamma-knife surgery for VS at our institution. We followed 175 …

Extended Survival in Patients With Non–Small-Cell Lung Cancer–Associated Brain Metastases in the Modern Era

Assaf Berger, Reed Mullen, Kenneth Bernstein, Juan Diego Alzate et autres

BACKGROUND: Brain metastases (BM) have long been considered a terminal diagnosis with management mainly aimed at palliation and little hope for extended survival. Use of brain stereotactic radiosurgery (SRS) and/or resection, in addition to novel systemic therapies, has enabled improvements in overall …

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Up-front single-session radiosurgery for large brain metastases—volumetric responses and outcomes

Carolina Benjamin, Jason Gurewitz, Aya Nakamura, Monica Mureb et autres

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