Deepak Mundkinajeddu

An Examination into the Anti-stress and Anti-fatigue Effects of an Ashwagandha Extract (Ashwa.30™) in Stressed Adults: A Randomised, Double-Blind, Placebo-controlled Trial

Adrian L. Lopresti, Stephen J. Smith, Bharathi Bethapudi, Auxi Arobana R et autres

INTRODUCTION: Ashwagandha supplementation has been associated with reduced self-reported stress and anxiety, although most trials have used doses of 250-600 mg daily for 6-8 weeks. This study examined the effects of a low-dose ashwagandha extract (Ashwa.30™) on perceived stress, mood, fatigue, and …

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Scale-Up Isolation of High-Purity Shatavarins from Asparagus racemosus via Flash Chromatography with Bioavailability and Pharmacological Insights

Devendra D C, Aboli Girme, Kavya Salvankar, Ashish A. Chinchansure et autres

, commonly known as Shatavari, is an established Ayurvedic plant whose bioactivity is credited to its steroidal saponins, generally referred to as shatavarins, exerting adaptogenic and estrogenic effects. However, traditional methods of isolation often produce products with limited purity and poor reproducibility, …

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Correction: Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic–pituitary–adrenal (HPA) axis in modulating stress

Mohan Gowda C. M., Sasikumar Murugan, Bharathi Bethapudi, Divya Purusothaman et autres

[This corrects the article DOI: 10.1371/journal.pone.0285012.].

Residual solvents in botanical extracts used in food supplements: a regulatory conundrum for scientific justification

Deepak Mundkinajeddu, Rojison Koshy, J. Nithin, Aboli Girme et autres

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Ashwa.30: A Bioactive-Optimized Ashwagandha Extract for Clinically Validated Low-Dose Efficacy.

Suresh Lakshmikanthan, Deepak Mundkinajeddu, Bharathi Bethapudi

Ashwa.30 is a clinically validated, dual-standardized extract of Withania somnifera developed using Bioactive Optimization Technology (B.O.T.). Unlike conventional high-dose ashwagandha products, Ashwa.30 achieves efficacy at a low 30 mg/day dosage through a synergistic combination of withanolides and a proprietary ATP-active fraction. Preclinical …

Assessment of genotoxicity and acute oral toxicity of a standardized Ocimum tenuiflorum extract (Holixer TM )

Sasikumar Murugan, Bharathi Bethapudi, Deepak Mundkinajeddu, Prashanth D’Souza

Ocimum tenuiflorum, commonly referred to as holy basil or Tulsi, has a long history of use in traditional medicine systems, particularly Ayurveda, due to its various health benefits, including anti-inflammatory, antioxidant, and adaptogenic properties. In contemporary contexts, this plant is progressively incorporated …

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Evaluation of Immunomodulatory Activity of a Polyherbal Formulation (Phytocee™) Using ex vivo and in vitro Models

M. Naveen Kumar, Sasikumar Murugan, Bharathi Bethapudi, Deepak Mundkinajeddu

Background The immune system plays a crucial role in protecting the host by regulating biological activities in multiple organs and circulatory fluids. The phytoextracts are evident to modulate a series of biological activities and play a protective role in managing healthy conditions …

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Assessment of Immunomodulatory Activity of AP-Bio® (KalmCold®), a Standardized Extract of Andrographis paniculata Using in vivo and ex vivo Models

Nehru Sai Suresh Chalichem, Prathiksha Nabhan, Bharathi Bethapudi, Nikita Agarwal et autres

Background Andrographis paniculata (Burm. f.) Nees is a well-recognized medicinal plant known for its benefits against a multitude of ailments. The intent of the present study was to evaluate the effect of a standardized extract of A. paniculata on innate immunity. Materials …

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Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma

Soumya Ranjan Mishra, Bishnu Prasad Behera, V. Singh, Kewal Kumar Mahapatra et autres

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Toxicological safety assessment of AP‐Bio®, a standardized extract of Andrographis paniculata in Sprague Dawley rats

Sasikumar Murugan, Bharathi Bethapudi, Amara Nageswara Rao, J. Joshua Allan et autres

Abstract Andrographis paniculata, commonly known as green chiretta, is a traditionally used plant in India, China, and Southeast Asian countries for its varied health benefits including immune health. The objective of the present study was to assess the safety of AP‐Bio®, a …

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Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic–pituitary–adrenal (HPA) axis in modulating stress

Mohan Gowda C. M., Sasikumar Murugan, Bharathi Bethapudi, Divya Purusothaman et autres

Ocimum tenuiflorum is a sacred medicinal plant bestowed with multiple health benefits. This plant is traditionally considered an adaptogen. Many scientific studies have indicated the anti-stress potential of Ocimum tenuiflorum but with higher doses. The present study investigated the effects of HolixerTM …

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Comparison of Chemistry and Zebrafish Toxicological Profile of Extract Processed as Per Traditional Method and of its Fraction for Similarity/Dissimilarity – A Case Study of Terminalia chebula Fruit

Rojison Koshy, D B Anantha Narayana, Smriti Yadav, V. Singh et autres

History of safe use, HoSU preparations are formulations mentioned in ancient literature and are according to the Ayurvedic system of medicine. Due to the advent of new technologies, there is a shift in the manufacturing methodologies of Ayurvedic medicines involving extractions and …

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