Karim Lakhal

Restrictive vs Liberal Transfusion Strategy in Traumatic Brain Injury

Irene Sbaraini Zernini, Chiara Faso, Carla Bittencourt Rynkowski, Kirsten Moller et autres

Importance: Anemia is a prevalent condition among patients with traumatic brain injury (TBI); however, the optimal hemoglobin (Hb) threshold to initiate red blood cell transfusion (RBCT) is not well defined. Objective: To assess which of 2 different Hb thresholds for guiding RBCT …

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CSF pharmacokinetics-pharmacodynamics of linezolid in critically brain injured patients, with or without central nervous system healthcare-associated infection. The PK-Pop-LCR Study: A Multicentre Pharmacokinetics and Pharmacodynamics Population Study

Claire Dahyot‐Fizelier, Alexia Chauzy, Kévin Chalard, F. Bernard et autres

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Aortic remodeling after zone 0 simplified delivery frozen elephant trunk (SD-FET) technique in acute aortic dissection: one-year clinical and morphological results in a single centre

Antoine Buschiazzo, Guillaume Guimbretière, Tom Le Corvec, Béatrice Guyomarch et autres

Background: The simplified delivery frozen elephant trunk (SD-FET) technique enables a one-step repair of type A acute aortic dissection (AAD) with stent proximalisation and very short normothermic circulatory arrest. This study reports early and 1-year clinical outcomes together with aortic remodelling in …

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Impact of sex on outcomes in critically ill patients with subarachnoid hemorrhage: a secondary analysis of a French prospective cohort study

Sylvain Gourier, Marwan Bouras, Karim Lakhal, Yoann Launey et autres

BACKGROUND: Aneurysmal subarachnoid hemorrhage (aSAH) remains a severe condition with high morbidity and mortality. Evidence on sex-related differences in outcomes and complication profiles is inconsistent. We assessed the association between sex and 90-day functional outcome and ICU complications in aSAH patients requiring …

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Apnea test for brain-death determination: a seven-years retrospective study in a French university hospital

Baptiste Hirsinger, Laurent Martin Lefèvre, Karim Lakhal, Alexandre Bourdiol et autres

BACKGROUND: The apnea test is essential for the diagnosis of brain death / death by neurologic criteria (BD/DNC), but clinical data are scarce especially in European Union. Our aim was to answer how often and why apnea testing was not done or …

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Predictive factors of successful renal replacement therapy weaning

Khalil Chaïbi, Yanis Akrour, Guillaume Louis, Laurent Martin Lefevre et autres

INTRODUCTION: Renal replacement therapy (RRT) is a life-saving intervention in severe acute kidney injury (AKI). After a clinician-initiated discontinuation, the likelihood of sustained liberation remains uncertain. We aimed to identify predictors of successful RRT weaning and to develop a pragmatic bedside tool …

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High-flow nasal-cannula oxygen therapy in intensive-care-unit patients: a prospective multicenter observational cohort study (OHE-REA)

Paul Compagne, Stephan Ehrmann, Maud Jonas, Jean Morin et autres

High-flow oxygen therapy (HFOT) has become the most common oxygen-supplementation modality in patients with acute respiratory failure, based chiefly on data from tightly selected patients included in randomized trials. Our objective was to obtain real-life data on HFOT failure. This prospective observational …

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Describing hemodynamic states: a plea for systematic terminology

Bernd Saugel, Karim Lakhal

A clear and systematic terminological framework is essential for exactly describing a patient's hemodynamic state. After assessing absolute values of hemodynamic variables and considering the specific clinical context, the absolute values should be classified as 'normal', 'higher than normal', or 'lower than …

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Factors associated with adverse haemodynamic events during the STARRT-AKI trial: a post-hoc secondary analysis

Yvelynne P. Kelly, Bruno R. da Costa, William Beaubien-Souligny, Edward G. Clark et autres

INTRODUCTION: Haemodynamic adverse events related to renal replacement therapy are a complication of all RRT modalities used in the ICU, including intermittent haemodialysis (IHD), sustained low efficiency dialysis (SLED) and continuous renal replacement therapy (CRRT). At present it is unclear which risk …

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Beyond global trueness and precision: evaluating the clinical suitability of automated brachial cuff blood pressure measurements in acute care—a protocol for systematic review and meta-analysis of aggregated and individual participant data

Jérôme E. Dauvergne, Karim Lakhal, Thierry Boulain

BACKGROUND: Invasive intra-arterial blood pressure (IABP) monitoring using an arterial catheter carries both risks and practical limitations. Noninvasive blood pressure (NIBP) monitoring using the widely adopted oscillometric automated brachial cuff is performed in nearly all patients in acute care settings at some …

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Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: A single-blinded prospective multicenter stepped wedge cluster randomized trial in French context

Mickaël Vourc’h, Elodie Boissier, Karim Lakhal, Sandrine Grosjean et autres

BACKGROUND: The IMOTEC study aims to determine whether a point-of-care viscoelastic hemostatic assay (VHA)-guided algorithm is cost-effective for the management of ongoing bleeding. METHODS: Stepped wedge cluster randomized trial, patient blinded, conducted at 16 French academic cardiac surgery centers from 01/2017 to …

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Impact of cerebral vasospasm therapy on nimodipine exposure in subarachnoid hemorrhage: A population pharmacokinetic study

Adrien Foucher, Matthieu Grégoire, Jérôme E. Dauvergne, Elodie Boissier et autres

BACKGROUND: ) - an unexplored pharmacokinetic aspect. METHODS: . RESULTS: in the final pharmacokinetic model, with BSA exerting a stronger and more consistent effect than MAP. Beyond MAP's own limited effect, hemodynamic augmentation therapy per se had no significant influence on nimodipine …

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