Accès ouvert
2026
preprint
OpenAlex
Anna J Park, Sarah Fish, Colby L. Samstag, M. Kim et autres
Abstract Mutations in the gene glucosidase, beta acid 1 (GBA1) are the strongest genetic risk factor for Parkinson’s disease (PD) and are associated with faster disease progression. GBA1 is expressed in all cell types of the central nervous system, with some evidence …
us
(code pays fourni par la source)
2024
article
OpenAlex
Jeremy C. Weiss, Sarah Fish, Arnav Khera, Anna Park et autres
To investigate if restoring GBA1 function in astrocytes can reduce the spread of Lewy pathology in neurons.
us
(code pays fourni par la source)
2023
article
OpenAlex
Arnav Khera, Sarah Fish, Raja Estes, Selina Yu et autres
Objective: To investigate mechanisms underlying the clinical observation that GBA mutations are associated with increased risk of developing PD, along with faster progression of motor and cognitive symptoms. Background: Mutations in the gene glucosidase, beta acid 1 (GBA) are the strongest genetic …
us
(code pays fourni par la source)
2022
article
OpenAlex
Raja Estes, Bernice Lin, Jessica E. Young, Marie Y. Davis
To investigate if GBA has a neuroprotective role in astrocytes.
us, in
(code pays fourni par la source)
2022
article
OpenAlex
Arnav Khera, Bernice Lin, Kathryn A. Jewett, Ruth E. Thomas et autres
To investigate why GBA mutations are associated with faster progression of Parkinson’s disease (PD).
us
(code pays fourni par la source)