Yoshiaki Matsushima

Refractory periorbital necrobiotic xanthogranuloma

Keiichi Yamanaka, Yoshiaki Matsushima

A woman in her mid-seventies presented with progressive, indurated yellow-orange periorbital and facial swelling; histopathological examination demonstrated necrobiotic granulomatous inflammation with foamy histiocytes, multinucleated giant cells and cholesterol clefts, establishing a diagnosis of necrobiotic xanthogranuloma. Systemic evaluation revealed an IgA-predominant immunoglobulin abnormality …

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Lymphoplasmacytic Plaque on the Dorsum of the Foot: Rapid Response to Potent Topical Corticosteroid

Yukako Suga, Yoshiaki Matsushima, Shohei Iida, Akinobu Hayashi et autres

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Differential Profiles of IL ‐31‐ and IL ‐5/ IL ‐13‐Producing Cells Among Helper T Cells, With Subtle IL ‐31 Expression in Innate Lymphoid Cells

Mai Nishimura, Yasutomo Imai, Yoshiaki Matsushima, Keiichi Yamanaka

The authors declare no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request. Figure S1: The gating hierarchy for cytokine expression patterns in lymphocytes from cervical lymph nodes was shown. …

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Mechanobiology of neutrophil inflammasome signaling in psoriasis

Yoshiaki Matsushima, Samuel T. Hwang, Scott Irwin Simon

While T cells play a prominent role, polymorphonuclear neutrophils (PMN) are also significant players in the pathogenesis of psoriasis. This review details the mechanobiology of PMN in the amplification of skin inflammation, a process often under-scrutinized compared to T cell pathways. PMN …

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Distinct changes in tissue-resident memory T cells following dupilumab treatment in atopic dermatitis

Mai Nishimura, Toru Ogura, Yoshiaki Matsushima, Keiichi Yamanaka

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0601 A murine model of psoriasis and atopic dermatitis induced with a combination of systemic IL-23 overexpression and topical application of the vitamin D3 analog MC903

H. Uchida, Kaiqun Ren, Xiujie Wu, Yoshiaki Matsushima et autres

LB1141 Signs of systemic inflammation (as detected by PET/CT imaging, transcription analysis, and neutrophil activation) in a moderately obese psoriasis patient are partially reversed by 6 weeks of dietary intervention with a healthy diet

Francene M. Steinberg, Ambalal Chaudhari, Sean L. Wyatt, Yasser G. Abdelhafez et autres

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Enhanced Innate Immunity Mediated by IL-36α in Atopic Dermatitis and Differences in Cytokine Profiles of Lymphocytes in the Skin and Draining Lymph Nodes

Ayaka Ichikawa, Mai Nishimura, Masako Ichishi, Yasutomo Imai et autres

(1) Background: The IL-36 cytokines have been identified as key contributors to pustular psoriasis, and their inhibitor is already in clinical use. However, few studies have explored them in atopic dermatitis. (2) Methods: The role of IL-36α was investigated in various atopic …

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Amelioration of Systemic Amyloidosis by Blocking IL-17A and Not by IL-17F, and Arteriosclerosis by Blocking Both IL-17A and IL-17F in an Inflammatory Skin Mouse Model

Takehisa Nakanishi, Shohei Iida, Masako Ichishi, Makoto Kondo et autres

There are comorbidities and complications in atopic dermatitis and psoriasis that often occur after the appearance of skin inflammation. Statistically, data show that patients with psoriasis and atopic dermatitis have a shorter life expectancy than patients without psoriatic dermatitis, due to the …

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The Skinny on Dermal Fat and Its Anti-Inflammatory Role in Psoriasis

Yoshiaki Matsushima, Samuel T. Hwang, Scott Irwin Simon

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Increased Mortality Risk at Septic Condition in Inflammatory Skin Disorders and the Effect of High-Fat Diet Consumption

Mai Nishimura, Takehisa Nakanishi, Masako Ichishi, Yoshiaki Matsushima et autres

In recent years, attention has increasingly focused on various infectious diseases. Although some fatalities are directly attributed to the causative virus, many result from complications and reactive inflammation. Patients with comorbidities are at a higher risk of mortality. Refractory skin conditions such …

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Consideration of serum IL ‐36α and β levels trends in two patients with chikungunya fever

Makoto Kondo, Yoshiaki Matsushima, Takehisa Nakanishi, Shohei Iida et autres

Key Clinical Message: IL-36 might play a role as an initial immune mechanism against chikungunya fever, and regulating IL-36 production could be a potential treatment approach for this condition. Abstract: Two Japanese siblings visited Cook Islands in 2015 and developed Chikungunya fever …

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