Laurie A. Loevner

Combined Metabolic and Microstructural Tractometry of the Superior Longitudinal Fasciculus in Healthy Brains: A Proof-of-Concept Study

Archith Rajan, Sourav Bhaduri, Subhanon Bera, Laiz Laura de Godoy et autres

Abstract Introduction The superior longitudinal fasciculus (SLF) is a major association fiber bundle implicated in cognition, visuospatial attention, language, and motor control, and its impairment is linked to several neurological and neuropsychiatric disorders. This proof-of-concept study was performed with three main objectives …

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The History of Women in Neuroradiology in North America from 1990 to the Present

AG Osborn, Patricia A Rhyner, Carolyn C. Meltzer, Pamela Whitney Schaefer et autres

Abstract From 1990 to 2024, women neuroradiologists in North America have made tremendous progress in the areas of leadership, clinical innovation, research, education, diversity, equity and inclusion, and global outreach. This chapter begins with summaries of their key accomplishments in four broad …

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MON-336 Diagnostic Utility of I 123 Hybrid SPECT/CT in the Characterization of Retropharyngeal Masses

Maryam I. Khan, Steven I. Sherman, Jill E. Langer, Laurie A. Loevner et autres

Abstract Disclosure: M.I. Khan: None. S.I. Sherman: None. J.E. Langer: None. L.A. Loevner: None. C. Schmalbach: None. N. Vijayvargia: None. D. Weinberg: None. S. Rubin: None. J.W. Lazor: None. R. Viterbo: None. A. Kutikov: None. R. Satriale: None. K. Chernukha: None. N. …

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Innovative Educational Program to Aid Clinical Vessel Wall MR Imaging Interpretation among Neuroradiologists

Jae W. Song, Ronald L. Wolf, Alvand Hassankhani, John H. Woo et autres

Innovations that introduce new knowledge domains face greater barriers to adoption, often requiring investment in infrastructure, training/education, and cultural change. Sustaining and scaling an advanced clinical vessel wall MR imaging program requires technical resources and subspecialized neuroradiologists with advanced cerebrovascular expertise. A …

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Time Is Spine: A Novel Radiology Reporting System for Optimizing Spine Oncology Decision-Making and Reducing Time to Treatment

Colbey W. Freeman, Raghav R. Mattay, Charles E. Kahn, Laurie A. Loevner et autres

ABSTRACT BACKGROUND AND PURPOSE: Patients with spinal metastases are at risk of instability and cord compression, requiring prompt diagnosis and timely intervention. Effective communication between radiologists and treatment teams is critical to ensure timely treatment. To address this, we developed a novel …

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Quantitative Physiologic MRI Combined with Feature Engineering for Developing Machine Learning-Based Prediction Models to Distinguish Glioblastomas from Single Brain Metastases

Seyyed Ali Hosseini, Stijn Servaes, Brandon Hall, Sourav Bhaduri et autres

Background: The accurate and early distinction of glioblastomas (GBMs) from single brain metastases (BMs) provides a window of opportunity for reframing treatment strategies enabling optimal and timely therapeutic interventions. We sought to leverage physiologically sensitive parameters derived from diffusion tensor imaging (DTI) …

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Non-invasive Detection of IDH-mutant Gliomas using Single and Multi-voxel Point-resolved Spectroscopy

Laiz Laura de Godoy, Gaurav Verma, Donald M. O’Rourke, MacLean P. Nasrallah et autres

IDH mutation has become one of the most important prognostic biomarkers in glioma management, regardless of histopathological features. The oncometabolite 2HG has been proposed as a biomarker for IDH-specific genetic profiles for gliomas. We report clinical utility of SVS and 1H-MRSI using …

Implementation of a Clinical Vessel Wall MR Imaging Program at an Academic Medical Center

Jae W. Song, Megan Y. Frame, Rob T. Sellers, Connie Klahn et autres

BACKGROUND AND PURPOSE: The slow adoption of new advanced imaging techniques into clinical practice has been a long-standing challenge. Principles of implementation science and the reach, effectiveness, adoption, implementation, maintenance (RE-AIM) framework were used to build a clinical vessel wall imaging program …

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Combined Orbital and Cranial Vessel Wall Magnetic Resonance Imaging for the Assessment of Disease Activity in Giant Cell Arteritis

Rennie L. Rhee, Ryan Rebello, Madhura A. Tamhankar, Shubhasree Banerjee et autres

OBJECTIVE: Acute visual impairment is the most feared complication of giant cell arteritis (GCA) but is challenging to predict. Magnetic resonance imaging (MRI) evaluates orbital pathology not visualized by an ophthalmologic examination. This study combined orbital and cranial vessel wall MRI to …

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Diseases of the Sella Turcica and Parasellar Region

Walter Kucharczyk, Laurie A. Loevner

Abstract Knowledge of the anatomy in the regions of the sella turcica, suprasellar cistern, and cavernous sinus paired with clinical history and presentation is important for accurate image interpretation. Focused diagnosis of lesions in these regions requires identifying the anatomic location in …

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Distinction of pseudoprogression from true progression in glioblastomas using machine learning based on multiparametric magnetic resonance imaging and O6-methylguanine-methyltransferase promoter methylation status

Virendra Kumar Yadav, Suyash Mohan, Sumeet Agarwal, Laiz Laura de Godoy et autres

Abstract Background It is imperative to differentiate true progression (TP) from pseudoprogression (PsP) in glioblastomas (GBMs). We sought to investigate the potential of physiologically sensitive quantitative parameters derived from diffusion and perfusion magnetic resonance imaging (MRI), and molecular signature combined with machine …

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ASSESSMENT OF TREATMENT RESPONSE TO DC VACCINE IN RECURRENT GBM PATIENTS USING MULTIPARAMETRIC MRI PREDICTION MODEL

Laiz de Godoy, Sumei Wang, Shadi Asadollahi, MacLean P. Nasrallah et autres

The highly aggressive nature of glioblastoma (GBM) leads to a dismal prognosis, and alternative therapies are being sought. Immunotherapy, such as the Dendritic Cell (DC) vaccine, is currently being evaluated for recurrent GBMs in clinical trials. Follow-up imaging after this immunotherapeutic approach …